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Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia.
World J Gastroenterol. 2013 Sep 21; 19(35):5883-8.WJ

Abstract

AIM

To investigate whether erosive esophagitis is correlated with metabolic syndrome and its components, abnormal liver function, and lipoprotein profiles.

METHODS

We conducted a cross-sectional, case control study of subjects who underwent upper endoscopy during a health examination at the Health Management and Evaluation Center of a tertiary medical care facility located in Southern Taiwan. Metabolic syndrome components, body mass index (BMI), liver function, dyslipidemia, and cardiovascular risk factors, as defined by the ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C), and the ratio of low-density lipoprotein cholesterol to HDL-C were compared between individuals with and without erosive esophagitis. Risk factors for erosive esophagitis were evaluated by multivariate logistic regression.

RESULTS

Erosive esophagitis was diagnosed in 507 of 5015 subjects who were individually age and sex matched to 507 esophagitis-free control subjects. In patients with erosive esophagitis, BMI, waist circumference, blood pressure, fasting plasma glucose, triglyceride levels, aspartate aminotransferase, alanine aminotransferase, the ratio of total cholesterol to HDL-C, and the ratio of low-density lipoprotein cholesterol to HDL-C were significantly higher and HDL-C was significantly lower compared to patients without erosive esophagitis (all P < 0.05). In a multivariate analysis, central obesity (OR = 1.38; 95%CI: 1.0-1.86), hypertension (OR = 1.35; 95%CI: 1.04-1.76), hypertriglyceridemia (OR = 1.34; 95%CI: 1.02-1.76), cardiovascular risk factors as defined by a ratio of total cholesterol to HDL-C > 5 (OR = 1.45; 95%CI: 1.06-1.97), and aspartate aminotransferase (OR = 1.59; 95%CI: 1.08-2.34) were significantly associated with erosive esophagitis.

CONCLUSION

Metabolic syndrome, impaired liver function, and a higher ratio of total cholesterol to HDL-C were associated with erosive esophagitis.

Authors+Show Affiliations

Song-Seng Loke, Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24124334

Citation

Loke, Song-Seng, et al. "Erosive Esophagitis Associated With Metabolic Syndrome, Impaired Liver Function, and Dyslipidemia." World Journal of Gastroenterology, vol. 19, no. 35, 2013, pp. 5883-8.
Loke SS, Yang KD, Chen KD, et al. Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia. World J Gastroenterol. 2013;19(35):5883-8.
Loke, S. S., Yang, K. D., Chen, K. D., & Chen, J. F. (2013). Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia. World Journal of Gastroenterology, 19(35), 5883-8. https://doi.org/10.3748/wjg.v19.i35.5883
Loke SS, et al. Erosive Esophagitis Associated With Metabolic Syndrome, Impaired Liver Function, and Dyslipidemia. World J Gastroenterol. 2013 Sep 21;19(35):5883-8. PubMed PMID: 24124334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia. AU - Loke,Song-Seng, AU - Yang,Kuender D, AU - Chen,Kuang-Den, AU - Chen,Jung-Fu, PY - 2013/02/26/received PY - 2013/06/13/revised PY - 2013/07/18/accepted PY - 2013/10/15/entrez PY - 2013/10/15/pubmed PY - 2014/3/14/medline KW - Abnormal liver function KW - Central obesity KW - Dyslipidemia KW - Erosive esophagitis KW - Metabolic syndrome SP - 5883 EP - 8 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 19 IS - 35 N2 - AIM: To investigate whether erosive esophagitis is correlated with metabolic syndrome and its components, abnormal liver function, and lipoprotein profiles. METHODS: We conducted a cross-sectional, case control study of subjects who underwent upper endoscopy during a health examination at the Health Management and Evaluation Center of a tertiary medical care facility located in Southern Taiwan. Metabolic syndrome components, body mass index (BMI), liver function, dyslipidemia, and cardiovascular risk factors, as defined by the ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C), and the ratio of low-density lipoprotein cholesterol to HDL-C were compared between individuals with and without erosive esophagitis. Risk factors for erosive esophagitis were evaluated by multivariate logistic regression. RESULTS: Erosive esophagitis was diagnosed in 507 of 5015 subjects who were individually age and sex matched to 507 esophagitis-free control subjects. In patients with erosive esophagitis, BMI, waist circumference, blood pressure, fasting plasma glucose, triglyceride levels, aspartate aminotransferase, alanine aminotransferase, the ratio of total cholesterol to HDL-C, and the ratio of low-density lipoprotein cholesterol to HDL-C were significantly higher and HDL-C was significantly lower compared to patients without erosive esophagitis (all P < 0.05). In a multivariate analysis, central obesity (OR = 1.38; 95%CI: 1.0-1.86), hypertension (OR = 1.35; 95%CI: 1.04-1.76), hypertriglyceridemia (OR = 1.34; 95%CI: 1.02-1.76), cardiovascular risk factors as defined by a ratio of total cholesterol to HDL-C > 5 (OR = 1.45; 95%CI: 1.06-1.97), and aspartate aminotransferase (OR = 1.59; 95%CI: 1.08-2.34) were significantly associated with erosive esophagitis. CONCLUSION: Metabolic syndrome, impaired liver function, and a higher ratio of total cholesterol to HDL-C were associated with erosive esophagitis. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24124334/Erosive_esophagitis_associated_with_metabolic_syndrome_impaired_liver_function_and_dyslipidemia_ L2 - https://www.wjgnet.com/1007-9327/full/v19/i35/5883.htm DB - PRIME DP - Unbound Medicine ER -