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Association of tobacco smoke exposure and atopic sensitization.
Ann Allergy Asthma Immunol 2013; 111(5):387-90AA

Abstract

BACKGROUND

Forty million children are regularly exposed to environmental tobacco smoke (ETS) each year, increasing their risk for premature death and middle ear and acute respiratory infections. Early life exposure to ETS also is clearly associated with wheezing. However, there is no clear understanding of the influence of ETS on the development of allergic sensitization.

OBJECTIVE

To determine the association of combined exposure to ETS and indoor allergens on IgE sensitization to aeroallergens in children.

METHODS

This case-control study enrolled 116 cases and 121 controls from low-income families from Kansas City, Missouri. The adjusted odds ratio was calculated using a logistic model to assess the association between ETS and allergic sensitization using dust allergen levels as a covariate.

RESULTS

Thirty-six percent of atopic children and 39% of controls were exposed to ETS (P < .05). Unadjusted analyses showed no significant influence of ETS on IgE sensitization to indoor allergens. Logistic regression analyses also showed no significant influence of ETS on sensitization when adjusted for levels of allergens in the home dust and family history of allergic rhinitis.

CONCLUSION

These data suggest that ETS exposure was not associated with IgE sensitization to indoor allergens, even when home allergen levels were taken into consideration. Further understanding of how components of tobacco smoke influence the immune response is necessary to interpret the disparate findings across studies.

Authors+Show Affiliations

Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri. Electronic address: ceciaccio@cmh.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24125146

Citation

Ciaccio, Christina E., et al. "Association of Tobacco Smoke Exposure and Atopic Sensitization." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 111, no. 5, 2013, pp. 387-90.
Ciaccio CE, DiDonna AC, Kennedy K, et al. Association of tobacco smoke exposure and atopic sensitization. Ann Allergy Asthma Immunol. 2013;111(5):387-90.
Ciaccio, C. E., DiDonna, A. C., Kennedy, K., Barnes, C. S., Portnoy, J. M., & Rosenwasser, L. J. (2013). Association of tobacco smoke exposure and atopic sensitization. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 111(5), pp. 387-90. doi:10.1016/j.anai.2013.07.023.
Ciaccio CE, et al. Association of Tobacco Smoke Exposure and Atopic Sensitization. Ann Allergy Asthma Immunol. 2013;111(5):387-90. PubMed PMID: 24125146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of tobacco smoke exposure and atopic sensitization. AU - Ciaccio,Christina E, AU - DiDonna,Anita C, AU - Kennedy,Kevin, AU - Barnes,Charles S, AU - Portnoy,Jay M, AU - Rosenwasser,Lanny J, Y1 - 2013/08/20/ PY - 2013/06/10/received PY - 2013/07/18/revised PY - 2013/07/18/accepted PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2013/12/16/medline SP - 387 EP - 90 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 111 IS - 5 N2 - BACKGROUND: Forty million children are regularly exposed to environmental tobacco smoke (ETS) each year, increasing their risk for premature death and middle ear and acute respiratory infections. Early life exposure to ETS also is clearly associated with wheezing. However, there is no clear understanding of the influence of ETS on the development of allergic sensitization. OBJECTIVE: To determine the association of combined exposure to ETS and indoor allergens on IgE sensitization to aeroallergens in children. METHODS: This case-control study enrolled 116 cases and 121 controls from low-income families from Kansas City, Missouri. The adjusted odds ratio was calculated using a logistic model to assess the association between ETS and allergic sensitization using dust allergen levels as a covariate. RESULTS: Thirty-six percent of atopic children and 39% of controls were exposed to ETS (P < .05). Unadjusted analyses showed no significant influence of ETS on IgE sensitization to indoor allergens. Logistic regression analyses also showed no significant influence of ETS on sensitization when adjusted for levels of allergens in the home dust and family history of allergic rhinitis. CONCLUSION: These data suggest that ETS exposure was not associated with IgE sensitization to indoor allergens, even when home allergen levels were taken into consideration. Further understanding of how components of tobacco smoke influence the immune response is necessary to interpret the disparate findings across studies. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/24125146/Association_of_tobacco_smoke_exposure_and_atopic_sensitization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(13)00522-X DB - PRIME DP - Unbound Medicine ER -