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Paracoccidioides brasiliensis infection in domestic rabbits (Oryctolagus cuniculus).
Mycoses. 2014 Apr; 57(4):222-7.M

Abstract

The objective of this study was to evaluate the infection of domestic rabbits by Paracoccidioides brasiliensis. Initially two rabbits were experimentally infected with P. brasiliensis and the humoral immune response was evaluated by ELISA using gp43 as antigen. The two animals showed IgG response against gp43 although no signs of disease were observed. The seroepidemiological study was carried out in 170 rabbits (free range n = 81 and caged n = 89) living in an endemic area for human paracoccidioidomycosis and a positivity of 27% was observed in the ELISA using gp43 as antigen. The free-range rabbits showed a significantly higher positivity (34.6-51.7%) than the caged animals (11.1%). Sentinel rabbits exposed to natural infection with P. brasiliensis were followed up for 6 months and a seroconversion rate of 83.3% was observed. This is the first report of paracoccidioidomycosis in rabbits and suggests that this species can be useful sentinels for P. brasiliensis presence in the environment.

Authors+Show Affiliations

Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24125519

Citation

Belitardo, Donizeti Rodrigues, et al. "Paracoccidioides Brasiliensis Infection in Domestic Rabbits (Oryctolagus Cuniculus)." Mycoses, vol. 57, no. 4, 2014, pp. 222-7.
Belitardo DR, Calefi AS, Sbeghen MR, et al. Paracoccidioides brasiliensis infection in domestic rabbits (Oryctolagus cuniculus). Mycoses. 2014;57(4):222-7.
Belitardo, D. R., Calefi, A. S., Sbeghen, M. R., de Oliveira, G. G., Watanabe, M. A., de Camargo, Z. P., & Ono, M. A. (2014). Paracoccidioides brasiliensis infection in domestic rabbits (Oryctolagus cuniculus). Mycoses, 57(4), 222-7. https://doi.org/10.1111/myc.12146
Belitardo DR, et al. Paracoccidioides Brasiliensis Infection in Domestic Rabbits (Oryctolagus Cuniculus). Mycoses. 2014;57(4):222-7. PubMed PMID: 24125519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paracoccidioides brasiliensis infection in domestic rabbits (Oryctolagus cuniculus). AU - Belitardo,Donizeti Rodrigues, AU - Calefi,Atilio Sersun, AU - Sbeghen,Mônica Raquel, AU - de Oliveira,Gabriela Gonçalves, AU - Watanabe,Maria Angelica Ehara, AU - de Camargo,Zoilo Pires, AU - Ono,Mario Augusto, Y1 - 2013/10/11/ PY - 2013/05/07/received PY - 2013/08/03/revised PY - 2013/09/12/accepted PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/10/28/medline KW - epidemiology KW - infection KW - paracoccidioidomycosis KW - systemic mycosis SP - 222 EP - 7 JF - Mycoses JO - Mycoses VL - 57 IS - 4 N2 - The objective of this study was to evaluate the infection of domestic rabbits by Paracoccidioides brasiliensis. Initially two rabbits were experimentally infected with P. brasiliensis and the humoral immune response was evaluated by ELISA using gp43 as antigen. The two animals showed IgG response against gp43 although no signs of disease were observed. The seroepidemiological study was carried out in 170 rabbits (free range n = 81 and caged n = 89) living in an endemic area for human paracoccidioidomycosis and a positivity of 27% was observed in the ELISA using gp43 as antigen. The free-range rabbits showed a significantly higher positivity (34.6-51.7%) than the caged animals (11.1%). Sentinel rabbits exposed to natural infection with P. brasiliensis were followed up for 6 months and a seroconversion rate of 83.3% was observed. This is the first report of paracoccidioidomycosis in rabbits and suggests that this species can be useful sentinels for P. brasiliensis presence in the environment. SN - 1439-0507 UR - https://www.unboundmedicine.com/medline/citation/24125519/Paracoccidioides_brasiliensis_infection_in_domestic_rabbits__Oryctolagus_cuniculus__ L2 - https://doi.org/10.1111/myc.12146 DB - PRIME DP - Unbound Medicine ER -