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A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat.
Bone. 2014 Jan; 58:151-9.BONE

Abstract

Dried plum has been reported to have potent effects on bone in osteopenic animal models, but the mechanisms through which bone metabolism is altered in vivo remain unclear. To address this issue, a study comparing the metabolic response of dried plum to the anabolic agent, parathyroid hormone (PTH), was undertaken. Six month-old female Sprague Dawley rats (n=84) were sham-operated (SHAM) or ovariectomized (OVX) and maintained on a control diet for 6wks until osteopenia was confirmed. Treatments were initiated consisting of a control diet (AIN-93M) supplemented with dried plum (0, 5, 15 or 25%; w/w) or a positive control group receiving PTH. At the end of 6wks of treatment, whole body and femoral bone mineral density (BMD) were restored by the two higher doses of dried plum to the level of the SHAM group. Trabecular bone volume and cortical thickness were also improved with these two doses of dried plum. Dried plum suppressed the OVX-induced increase in bone turnover as indicated by systemic biomarkers of bone metabolism, N-terminal procollagen type 1 (P1NP) and deoxypyridinoline (DPD). Dynamic bone histomorphometric analysis of the tibial metaphysis revealed that dried plum restored the OVX-induced increase in cancellous bone formation rate (BFR) and mineralizing surface (MS/BS) to the SHAM group, but some doses of dried plum increased endocortical mineral apposition rate (MAR). As expected, PTH significantly increased endocortical MAR and BFR, periosteal BFR, and trabecular MAR and BFR beyond that of the OVX and maintained the accelerated rate of bone resorption associated with OVX. Dried plum up-regulated bone morphogenetic protein 4 (Bmp4) and insulin-like growth factor 1 (Igf1) while down-regulating nuclear factor T cell activator 1 (Nfatc1). These findings demonstrate that in the adult osteopenic OVX animal, the effects of dried plum differ from that of PTH in that dried plum primarily suppressed bone turnover with the exception of the indices of bone formation at the endocortical surface.

Authors+Show Affiliations

Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA. Electronic address: bjsmith@okstate.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24125756

Citation

Smith, Brenda J., et al. "A Comparative Study of the Bone Metabolic Response to Dried Plum Supplementation and PTH Treatment in Adult, Osteopenic Ovariectomized Rat." Bone, vol. 58, 2014, pp. 151-9.
Smith BJ, Bu SY, Wang Y, et al. A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone. 2014;58:151-9.
Smith, B. J., Bu, S. Y., Wang, Y., Rendina, E., Lim, Y. F., Marlow, D., Clarke, S. L., Cullen, D. M., & Lucas, E. A. (2014). A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone, 58, 151-9. https://doi.org/10.1016/j.bone.2013.10.005
Smith BJ, et al. A Comparative Study of the Bone Metabolic Response to Dried Plum Supplementation and PTH Treatment in Adult, Osteopenic Ovariectomized Rat. Bone. 2014;58:151-9. PubMed PMID: 24125756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. AU - Smith,Brenda J, AU - Bu,So Young, AU - Wang,Yan, AU - Rendina,Elizabeth, AU - Lim,Yin F, AU - Marlow,Denver, AU - Clarke,Stephen L, AU - Cullen,Diane M, AU - Lucas,Edralin A, Y1 - 2013/10/11/ PY - 2013/08/06/received PY - 2013/09/28/revised PY - 2013/10/04/accepted PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/9/1/medline KW - AIN KW - Alp KW - American Institute of Nutrition KW - BAP KW - BFR KW - BMD KW - BMP KW - BV/TV KW - Bone histomorphometry KW - Coll1a KW - Conn Density KW - DP KW - DPD KW - DXA KW - Dried plum KW - Estrogen KW - GI KW - HD KW - IGF-I KW - LD KW - MAR KW - MD KW - MS KW - Menopause KW - N-terminal propeptide of type I procollagen KW - Nfatc1 KW - OPG KW - OVX KW - Osteoporosis KW - P1NP KW - PTH KW - Parathyroid hormone KW - Rankl KW - Runx2 KW - SD KW - SHAM KW - SHAM operated KW - Sprague Dawley KW - TNF-α KW - TRAP KW - TbN KW - TbSp KW - TbTh KW - VOI KW - alkaline phosphatase KW - bone formation rate KW - bone mineral density KW - bone morphogenetic protein KW - bone volume per total volume KW - bone-specific alkaline phosphatase KW - connectivity density KW - deoxypyridinoline crosslinks KW - dried plum KW - dual-energy X-ray absorptiometry KW - gastrointestinal tract KW - high dose dried plum KW - insulin-like growth factor-I KW - low dose dried plum KW - medium dose dried plum KW - micro-computed tomography KW - mineral apposition rate KW - mineralizing surface KW - nuclear factor for activated T cells 1 KW - osteoprotegerin KW - ovariectomized KW - parathyroid hormone KW - receptor activator for NF-kappa B ligand KW - runt-related transcription factor 2 KW - tartrate resistant acid phosphatase KW - trabecular number KW - trabecular separation KW - trabecular thickness KW - tumor necrosis factor-alpha KW - type I collagen KW - volume of interest KW - μCT SP - 151 EP - 9 JF - Bone JO - Bone VL - 58 N2 - Dried plum has been reported to have potent effects on bone in osteopenic animal models, but the mechanisms through which bone metabolism is altered in vivo remain unclear. To address this issue, a study comparing the metabolic response of dried plum to the anabolic agent, parathyroid hormone (PTH), was undertaken. Six month-old female Sprague Dawley rats (n=84) were sham-operated (SHAM) or ovariectomized (OVX) and maintained on a control diet for 6wks until osteopenia was confirmed. Treatments were initiated consisting of a control diet (AIN-93M) supplemented with dried plum (0, 5, 15 or 25%; w/w) or a positive control group receiving PTH. At the end of 6wks of treatment, whole body and femoral bone mineral density (BMD) were restored by the two higher doses of dried plum to the level of the SHAM group. Trabecular bone volume and cortical thickness were also improved with these two doses of dried plum. Dried plum suppressed the OVX-induced increase in bone turnover as indicated by systemic biomarkers of bone metabolism, N-terminal procollagen type 1 (P1NP) and deoxypyridinoline (DPD). Dynamic bone histomorphometric analysis of the tibial metaphysis revealed that dried plum restored the OVX-induced increase in cancellous bone formation rate (BFR) and mineralizing surface (MS/BS) to the SHAM group, but some doses of dried plum increased endocortical mineral apposition rate (MAR). As expected, PTH significantly increased endocortical MAR and BFR, periosteal BFR, and trabecular MAR and BFR beyond that of the OVX and maintained the accelerated rate of bone resorption associated with OVX. Dried plum up-regulated bone morphogenetic protein 4 (Bmp4) and insulin-like growth factor 1 (Igf1) while down-regulating nuclear factor T cell activator 1 (Nfatc1). These findings demonstrate that in the adult osteopenic OVX animal, the effects of dried plum differ from that of PTH in that dried plum primarily suppressed bone turnover with the exception of the indices of bone formation at the endocortical surface. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/24125756/A_comparative_study_of_the_bone_metabolic_response_to_dried_plum_supplementation_and_PTH_treatment_in_adult_osteopenic_ovariectomized_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(13)00383-9 DB - PRIME DP - Unbound Medicine ER -