Citation
Wang, Zhen, et al. "Antidepressant-like Activity of Resveratrol Treatment in the Forced Swim Test and Tail Suspension Test in Mice: the HPA Axis, BDNF Expression and Phosphorylation of ERK." Pharmacology, Biochemistry, and Behavior, vol. 112, 2013, pp. 104-10.
Wang Z, Gu J, Wang X, et al. Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. Pharmacol Biochem Behav. 2013;112:104-10.
Wang, Z., Gu, J., Wang, X., Xie, K., Luan, Q., Wan, N., Zhang, Q., Jiang, H., & Liu, D. (2013). Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. Pharmacology, Biochemistry, and Behavior, 112, 104-10. https://doi.org/10.1016/j.pbb.2013.10.007
Wang Z, et al. Antidepressant-like Activity of Resveratrol Treatment in the Forced Swim Test and Tail Suspension Test in Mice: the HPA Axis, BDNF Expression and Phosphorylation of ERK. Pharmacol Biochem Behav. 2013;112:104-10. PubMed PMID: 24125781.
TY - JOUR
T1 - Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK.
AU - Wang,Zhen,
AU - Gu,Jianhua,
AU - Wang,Xueer,
AU - Xie,Kai,
AU - Luan,Qinsong,
AU - Wan,Nianqing,
AU - Zhang,Qun,
AU - Jiang,Hong,
AU - Liu,Dexiang,
Y1 - 2013/10/11/
PY - 2013/06/28/received
PY - 2013/09/05/revised
PY - 2013/10/05/accepted
PY - 2013/10/16/entrez
PY - 2013/10/16/pubmed
PY - 2014/7/17/medline
KW - BDNF
KW - Brain derived neurotrophic factor (BDNF)
KW - ERK
KW - Extracellular signal-regulated kinase (ERK)
KW - FST
KW - Forced swim test
KW - HPA
KW - PFC
KW - RT-PCR
KW - Resveratrol
KW - TST
KW - Tail suspension test
KW - The hypothalamic–pituitary–adrenal axis
KW - brain derived neurotrophic factor
KW - extracellular signal-regulated kinase
KW - forced swim test
KW - hypothalamic–pituitary–adrenal
KW - prefrontal cortex
KW - reverse transcription-polymerase chain reaction
KW - tail suspension test
SP - 104
EP - 10
JF - Pharmacology, biochemistry, and behavior
JO - Pharmacol Biochem Behav
VL - 112
N2 - Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities. There is only limited information about the antidepressant-like effect of resveratrol. The present study assessed whether resveratrol treatment (20, 40 and 80mg/kg, i.p., 21days) has an antidepressant-like effect on the forced swim test (FST) and tail suspension test (TST) in mice and examined what its molecular targets might be. The results showed that resveratrol administration produced antidepressant-like effects in mice, evidenced by the reduced immobility time in the FST and TST, while it had no effect on the locomotor activity in the open field test. Resveratrol treatment significantly reduced serum corticosterone levels, which had been elevated by the FST and TST. Moreover, resveratrol increased brain-derived neurotrophic factor (BDNF) protein and extracellular signal-regulated kinase (ERK) phosphorylation levels in the prefrontal cortex and hippocampus. All of these antidepressant-like effects of resveratrol were essentially similar to those observed with the clinical antidepressant, fluoxetine. These results suggest that the antidepressant-like effects of resveratrol in the FST and TST are mediated, at least in part, by modulating hypothalamic-pituitary-adrenal axis, BDNF and ERK phosphorylation expression in the brain region of mice.
SN - 1873-5177
UR - https://www.unboundmedicine.com/medline/citation/24125781/Antidepressant_like_activity_of_resveratrol_treatment_in_the_forced_swim_test_and_tail_suspension_test_in_mice:_the_HPA_axis_BDNF_expression_and_phosphorylation_of_ERK_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(13)00241-4
DB - PRIME
DP - Unbound Medicine
ER -