TY - JOUR T1 - Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. AU - Wang,Zhen, AU - Gu,Jianhua, AU - Wang,Xueer, AU - Xie,Kai, AU - Luan,Qinsong, AU - Wan,Nianqing, AU - Zhang,Qun, AU - Jiang,Hong, AU - Liu,Dexiang, Y1 - 2013/10/11/ PY - 2013/06/28/received PY - 2013/09/05/revised PY - 2013/10/05/accepted PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/7/17/medline KW - BDNF KW - Brain derived neurotrophic factor (BDNF) KW - ERK KW - Extracellular signal-regulated kinase (ERK) KW - FST KW - Forced swim test KW - HPA KW - PFC KW - RT-PCR KW - Resveratrol KW - TST KW - Tail suspension test KW - The hypothalamic–pituitary–adrenal axis KW - brain derived neurotrophic factor KW - extracellular signal-regulated kinase KW - forced swim test KW - hypothalamic–pituitary–adrenal KW - prefrontal cortex KW - reverse transcription-polymerase chain reaction KW - tail suspension test SP - 104 EP - 10 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 112 N2 - Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities. There is only limited information about the antidepressant-like effect of resveratrol. The present study assessed whether resveratrol treatment (20, 40 and 80mg/kg, i.p., 21days) has an antidepressant-like effect on the forced swim test (FST) and tail suspension test (TST) in mice and examined what its molecular targets might be. The results showed that resveratrol administration produced antidepressant-like effects in mice, evidenced by the reduced immobility time in the FST and TST, while it had no effect on the locomotor activity in the open field test. Resveratrol treatment significantly reduced serum corticosterone levels, which had been elevated by the FST and TST. Moreover, resveratrol increased brain-derived neurotrophic factor (BDNF) protein and extracellular signal-regulated kinase (ERK) phosphorylation levels in the prefrontal cortex and hippocampus. All of these antidepressant-like effects of resveratrol were essentially similar to those observed with the clinical antidepressant, fluoxetine. These results suggest that the antidepressant-like effects of resveratrol in the FST and TST are mediated, at least in part, by modulating hypothalamic-pituitary-adrenal axis, BDNF and ERK phosphorylation expression in the brain region of mice. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/24125781/Antidepressant_like_activity_of_resveratrol_treatment_in_the_forced_swim_test_and_tail_suspension_test_in_mice:_the_HPA_axis_BDNF_expression_and_phosphorylation_of_ERK_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(13)00241-4 DB - PRIME DP - Unbound Medicine ER -