Tags

Type your tag names separated by a space and hit enter

The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma.
J Cancer Res Ther. 2013 Jul-Sep; 9(3):387-91.JC

Abstract

OBJECTIVE

Neo-vascularization is vital for an expansion and metastasis of a tumor and is influenced by a number of mediators. Mast cells are believed to release many pro-angiogenic mediators that may help in tumor expansion and invasion. This study describes the role of mast cells and angiogenesis in oral squamous cell carcinoma (OSCC).

STUDY DESIGN

It was a prospective study in which 37 biopsies of well-differentiated OSCC were obtained. Micro-vessels were stained with cluster of differentiation (CD)-34 and mast cells were counted using the Toluidine blue stain.

RESULTS

When compared to normal oral mucosal tissue, it was seen that micro-vessel density and mast cell density indeed increases significantly in squamous cell carcinoma; however, they are not correlated to each other.

CONCLUSION

This study reports that angiogenesis does increase in OSCC and mast cells also invade the peri-tumor tissue, but they are not directly correlated.

Authors+Show Affiliations

Department of Pathology, Quaid-e-Azam Medical College Bahawalpur, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24125971

Citation

Tahir, Ali, et al. "The Role of Mast Cells and Angiogenesis in Well-differentiated Oral Squamous Cell Carcinoma." Journal of Cancer Research and Therapeutics, vol. 9, no. 3, 2013, pp. 387-91.
Tahir A, Nagi AH, Ullah E, et al. The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma. J Cancer Res Ther. 2013;9(3):387-91.
Tahir, A., Nagi, A. H., Ullah, E., & Janjua, O. S. (2013). The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma. Journal of Cancer Research and Therapeutics, 9(3), 387-91. https://doi.org/10.4103/0973-1482.119311
Tahir A, et al. The Role of Mast Cells and Angiogenesis in Well-differentiated Oral Squamous Cell Carcinoma. J Cancer Res Ther. 2013 Jul-Sep;9(3):387-91. PubMed PMID: 24125971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of mast cells and angiogenesis in well-differentiated oral squamous cell carcinoma. AU - Tahir,Ali, AU - Nagi,Abdul Hannan, AU - Ullah,Ehsan, AU - Janjua,Omer Sefvan, PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/8/8/medline SP - 387 EP - 91 JF - Journal of cancer research and therapeutics JO - J Cancer Res Ther VL - 9 IS - 3 N2 - OBJECTIVE: Neo-vascularization is vital for an expansion and metastasis of a tumor and is influenced by a number of mediators. Mast cells are believed to release many pro-angiogenic mediators that may help in tumor expansion and invasion. This study describes the role of mast cells and angiogenesis in oral squamous cell carcinoma (OSCC). STUDY DESIGN: It was a prospective study in which 37 biopsies of well-differentiated OSCC were obtained. Micro-vessels were stained with cluster of differentiation (CD)-34 and mast cells were counted using the Toluidine blue stain. RESULTS: When compared to normal oral mucosal tissue, it was seen that micro-vessel density and mast cell density indeed increases significantly in squamous cell carcinoma; however, they are not correlated to each other. CONCLUSION: This study reports that angiogenesis does increase in OSCC and mast cells also invade the peri-tumor tissue, but they are not directly correlated. SN - 1998-4138 UR - https://www.unboundmedicine.com/medline/citation/24125971/The_role_of_mast_cells_and_angiogenesis_in_well_differentiated_oral_squamous_cell_carcinoma_ L2 - http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2013;volume=9;issue=3;spage=387;epage=391;aulast=Tahir DB - PRIME DP - Unbound Medicine ER -