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Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes.

Abstract

To examine the association between dietary habits, cognitive functioning and brain volumes in older individuals, data from 194 cognitively healthy individuals who participated in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort were used. At age 70, participants kept diaries of their food intake for 1week. These records were used to calculate a Mediterranean diet (MeDi) score (comprising dietary habits traditionally found in Mediterranean countries, e.g. high intake of fruits and low intake of meat), with higher scores indicating more pronounced MeDi-like dietary habits. Five years later, participants' cognitive capabilities were examined by the seven minute screening (7MS) (a cognitive test battery used by clinicians to screen for dementia), and their brain volumes were measured by volumetric magnetic resonance imaging. Multivariate linear regression analyses were constructed to examine the association between the total MeDi score and cognitive functioning and brain volumes. In addition, possible associations between MeDi's eight dietary features and cognitive functioning and brain volumes were investigated. From the eight dietary features included in the MeDi score, pertaining to a low consumption of meat and meat products was linked to a better performance on the 7MS test (P=0.001) and greater total brain volume (i.e. the sum of white and gray matter, P=0.03) when controlling for potential confounders (e.g. BMI) in the analysis. Integrating all dietary features into the total MeDi score explained less variance in cognitive functioning and brain volumes than its single dietary component meat intake. These observational findings suggest that keeping to a low meat intake could prove to be an impact-driven public health policy to support healthy cognitive aging, when confirmed by longitudinal studies. Further, they suggest that the MeDi score is a construct that may mask possible associations of single MeDi features with brain health domains in elderly populations.

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  • Authors+Show Affiliations

    ,

    Department of Neuroscience, Uppsala University, Sweden. Electronic address: olga.titova@neuro.uu.se.

    , , , , , , , , , , ,

    Source

    Experimental gerontology 48:12 2013 Dec pg 1443-8

    MeSH

    Age Factors
    Aged
    Aging
    Brain
    Cognition
    Diet, Mediterranean
    Feeding Behavior
    Female
    Geriatric Assessment
    Humans
    Linear Models
    Magnetic Resonance Imaging
    Male
    Meat
    Multivariate Analysis
    Neuropsychological Tests
    Organ Size
    Prospective Studies
    Sweden
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24126083

    Citation

    Titova, Olga E., et al. "Mediterranean Diet Habits in Older Individuals: Associations With Cognitive Functioning and Brain Volumes." Experimental Gerontology, vol. 48, no. 12, 2013, pp. 1443-8.
    Titova OE, Ax E, Brooks SJ, et al. Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. Exp Gerontol. 2013;48(12):1443-8.
    Titova, O. E., Ax, E., Brooks, S. J., Sjögren, P., Cederholm, T., Kilander, L., ... Benedict, C. (2013). Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. Experimental Gerontology, 48(12), pp. 1443-8. doi:10.1016/j.exger.2013.10.002.
    Titova OE, et al. Mediterranean Diet Habits in Older Individuals: Associations With Cognitive Functioning and Brain Volumes. Exp Gerontol. 2013;48(12):1443-8. PubMed PMID: 24126083.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. AU - Titova,Olga E, AU - Ax,Erika, AU - Brooks,Samantha J, AU - Sjögren,Per, AU - Cederholm,Tommy, AU - Kilander,Lena, AU - Kullberg,Joel, AU - Larsson,Elna-Marie, AU - Johansson,Lars, AU - Ahlström,Håkan, AU - Lind,Lars, AU - Schiöth,Helgi B, AU - Benedict,Christian, Y1 - 2013/10/11/ PY - 2013/05/18/received PY - 2013/09/04/revised PY - 2013/10/04/accepted PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/7/31/medline KW - 7MS KW - AD KW - Alzheimer's Disease KW - Brain morphometry KW - CI KW - Cognitive function KW - Confidence interval KW - EPN KW - Elderly KW - Ethics Committee of Uppsala KW - FWE KW - Family Wise Error KW - MCI KW - MMSE KW - MRI KW - Magnetic resonance imaging KW - MeDi KW - Meat intake KW - Mediterranean diet KW - Mild cognitive impairment KW - Mini-mental state examination KW - PIVUS KW - Prospective Investigation of the Vasculature in Uppsala Seniors KW - SEM KW - SPM KW - Seven minute screening KW - Standard error of mean KW - Statistical parametric mapping KW - TFE KW - Turbo Field Echo KW - VBM KW - Voxel Based Morphometry SP - 1443 EP - 8 JF - Experimental gerontology JO - Exp. Gerontol. VL - 48 IS - 12 N2 - To examine the association between dietary habits, cognitive functioning and brain volumes in older individuals, data from 194 cognitively healthy individuals who participated in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort were used. At age 70, participants kept diaries of their food intake for 1week. These records were used to calculate a Mediterranean diet (MeDi) score (comprising dietary habits traditionally found in Mediterranean countries, e.g. high intake of fruits and low intake of meat), with higher scores indicating more pronounced MeDi-like dietary habits. Five years later, participants' cognitive capabilities were examined by the seven minute screening (7MS) (a cognitive test battery used by clinicians to screen for dementia), and their brain volumes were measured by volumetric magnetic resonance imaging. Multivariate linear regression analyses were constructed to examine the association between the total MeDi score and cognitive functioning and brain volumes. In addition, possible associations between MeDi's eight dietary features and cognitive functioning and brain volumes were investigated. From the eight dietary features included in the MeDi score, pertaining to a low consumption of meat and meat products was linked to a better performance on the 7MS test (P=0.001) and greater total brain volume (i.e. the sum of white and gray matter, P=0.03) when controlling for potential confounders (e.g. BMI) in the analysis. Integrating all dietary features into the total MeDi score explained less variance in cognitive functioning and brain volumes than its single dietary component meat intake. These observational findings suggest that keeping to a low meat intake could prove to be an impact-driven public health policy to support healthy cognitive aging, when confirmed by longitudinal studies. Further, they suggest that the MeDi score is a construct that may mask possible associations of single MeDi features with brain health domains in elderly populations. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/24126083/Mediterranean_diet_habits_in_older_individuals:_associations_with_cognitive_functioning_and_brain_volumes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(13)00303-3 DB - PRIME DP - Unbound Medicine ER -