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Cardiovascular risk factors, carotid artery intima media thickness, and HSCRP levels in patients with impaired glucose metabolism.
Minerva Endocrinol. 2013 Sep; 38(3):297-304.ME

Abstract

AIM

The aim of this paper was to compare serum high sensitivity C-reactive protein (HsCRP) levels and carotid artery intima-media thickness (CIMT) of patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) with that in control subjects.

METHODS

Ninety-six subjects with prediabetes, 48 with IFG, of mean age 50.7±11.3 years, and 48 with IGT, of mean age 50.9±12.3 years, were enrolled, along with 44 age-, sex-, and body mass index-matched controls with normal glucose tolerance. Serum HsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) was evaluated. High-resolution B-mode ultrasonography was performed.

RESULTS

Serum HsCRP levels were significantly elevated in pre-diabetic patients when compared with that of control subjects. Median HsCRP values were 3.1 mg/L in IFG group, 3.47 mg/L in IGT group, and 1.5 mg/L in the controls (P<0.001). CIMT was significantly higher in pre-diabetic groups than that in the control group (IFG: 0.612±0.09; IGT: 0.625±0.1; control: 0.517±0.09, P<0.001). CIMT and HsCRP levels were similar in pre-diabetic groups. CIMT values were positively correlated with HsCRP (r=0.793, P=0.000), age (r=0.435, P=0.000), waist-hip ratio (r=0.170, P=0.044), fasting plasma glucose (r=0.302, P=0.000), HOMA-IR (r=0.173, P=0.041), and low-density lipoprotein cholesterol (r=0.168, P=0.047) levels.

CONCLUSION

Both IFG and IGT were associated with increased cardiovascular risk as assessed by serum hsCRP levels and CIMT. In contrast to previous studies, risk appears to be the same in the two categories of prediabetes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Dışkapı Yıldırım Beyazıt Teaching and Research hospital, Ankara, Turkey - b_karbek@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24126550

Citation

Karbek, B, et al. "Cardiovascular Risk Factors, Carotid Artery Intima Media Thickness, and HSCRP Levels in Patients With Impaired Glucose Metabolism." Minerva Endocrinologica, vol. 38, no. 3, 2013, pp. 297-304.
Karbek B, Cakal E, Cakir E, et al. Cardiovascular risk factors, carotid artery intima media thickness, and HSCRP levels in patients with impaired glucose metabolism. Minerva Endocrinol. 2013;38(3):297-304.
Karbek, B., Cakal, E., Cakir, E., Bozkurt, N., Unsal, I., Sahin, M., & Delibaşi, T. (2013). Cardiovascular risk factors, carotid artery intima media thickness, and HSCRP levels in patients with impaired glucose metabolism. Minerva Endocrinologica, 38(3), 297-304.
Karbek B, et al. Cardiovascular Risk Factors, Carotid Artery Intima Media Thickness, and HSCRP Levels in Patients With Impaired Glucose Metabolism. Minerva Endocrinol. 2013;38(3):297-304. PubMed PMID: 24126550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors, carotid artery intima media thickness, and HSCRP levels in patients with impaired glucose metabolism. AU - Karbek,B, AU - Cakal,E, AU - Cakir,E, AU - Bozkurt,N, AU - Unsal,I, AU - Sahin,M, AU - Delibaşi,T, PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/1/31/medline SP - 297 EP - 304 JF - Minerva endocrinologica JO - Minerva Endocrinol VL - 38 IS - 3 N2 - AIM: The aim of this paper was to compare serum high sensitivity C-reactive protein (HsCRP) levels and carotid artery intima-media thickness (CIMT) of patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) with that in control subjects. METHODS: Ninety-six subjects with prediabetes, 48 with IFG, of mean age 50.7±11.3 years, and 48 with IGT, of mean age 50.9±12.3 years, were enrolled, along with 44 age-, sex-, and body mass index-matched controls with normal glucose tolerance. Serum HsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) was evaluated. High-resolution B-mode ultrasonography was performed. RESULTS: Serum HsCRP levels were significantly elevated in pre-diabetic patients when compared with that of control subjects. Median HsCRP values were 3.1 mg/L in IFG group, 3.47 mg/L in IGT group, and 1.5 mg/L in the controls (P<0.001). CIMT was significantly higher in pre-diabetic groups than that in the control group (IFG: 0.612±0.09; IGT: 0.625±0.1; control: 0.517±0.09, P<0.001). CIMT and HsCRP levels were similar in pre-diabetic groups. CIMT values were positively correlated with HsCRP (r=0.793, P=0.000), age (r=0.435, P=0.000), waist-hip ratio (r=0.170, P=0.044), fasting plasma glucose (r=0.302, P=0.000), HOMA-IR (r=0.173, P=0.041), and low-density lipoprotein cholesterol (r=0.168, P=0.047) levels. CONCLUSION: Both IFG and IGT were associated with increased cardiovascular risk as assessed by serum hsCRP levels and CIMT. In contrast to previous studies, risk appears to be the same in the two categories of prediabetes. SN - 0391-1977 UR - https://www.unboundmedicine.com/medline/citation/24126550/Cardiovascular_risk_factors_carotid_artery_intima_media_thickness_and_HSCRP_levels_in_patients_with_impaired_glucose_metabolism_ L2 - http://www.minervamedica.it/index2.t?show=R07Y2013N03A0297 DB - PRIME DP - Unbound Medicine ER -