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Motor cortical inhibition in ADHD: modulation of the transcranial magnetic stimulation-evoked N100 in a response control task.
J Neural Transm (Vienna) 2014; 121(3):315-25JN

Abstract

The N100 component, evoked by transcranial magnetic stimulation (TMS) and electroencephalography is associated with the activation of inhibitory cortical circuits and has recently been suggested as a potential marker of inhibition in attention-deficit/hyperactivity disorder (ADHD). The aim of the present ADHD study was to investigate the modulation of the TMS-N100 in go and nogo trials of a response control task considering stages of response preparation, activation, execution and inhibition. Eighteen children with ADHD and 19 typically developing children, aged 10-14 years, were assessed. TMS was delivered over the left motor cortex, the TMS-N100 was measured at electrode P3. The TMS-N100 was determined at rest and at different time points (50 ms before S2; 150, 300 and 500 ms after S2) in a cued go/nogo task (S1-S2 paradigm). Correlations between the TMS-N100 measures, MEP-related TMS measures (e.g., short-interval intracortical inhibition) and performance measures were calculated. At rest, the amplitude of TMS-N100 was not found to be significantly reduced in the ADHD group. During the go/nogo task, children with ADHD showed a smaller increase of TMS-N100 amplitude in go trials and a smaller decrease after inhibiting a response. In go trials, a lower TMS-N100 was associated with a smaller variability of reaction times. A smaller TMS-N100 modulation extends the picture of cortical inhibition deficits in ADHD. Findings suggest a functional involvement of the mechanisms underlying the TMS-N100 at the motor output stage.

Authors+Show Affiliations

Unit of Child Neurology and Psychiatry, Department of Neuroscience, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24126573

Citation

D'Agati, Elisa, et al. "Motor Cortical Inhibition in ADHD: Modulation of the Transcranial Magnetic Stimulation-evoked N100 in a Response Control Task." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 121, no. 3, 2014, pp. 315-25.
D'Agati E, Hoegl T, Dippel G, et al. Motor cortical inhibition in ADHD: modulation of the transcranial magnetic stimulation-evoked N100 in a response control task. J Neural Transm (Vienna). 2014;121(3):315-25.
D'Agati, E., Hoegl, T., Dippel, G., Curatolo, P., Bender, S., Kratz, O., ... Heinrich, H. (2014). Motor cortical inhibition in ADHD: modulation of the transcranial magnetic stimulation-evoked N100 in a response control task. Journal of Neural Transmission (Vienna, Austria : 1996), 121(3), pp. 315-25. doi:10.1007/s00702-013-1097-7.
D'Agati E, et al. Motor Cortical Inhibition in ADHD: Modulation of the Transcranial Magnetic Stimulation-evoked N100 in a Response Control Task. J Neural Transm (Vienna). 2014;121(3):315-25. PubMed PMID: 24126573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor cortical inhibition in ADHD: modulation of the transcranial magnetic stimulation-evoked N100 in a response control task. AU - D'Agati,Elisa, AU - Hoegl,Thomas, AU - Dippel,Gabriel, AU - Curatolo,Paolo, AU - Bender,Stephan, AU - Kratz,Oliver, AU - Moll,Gunther H, AU - Heinrich,Hartmut, Y1 - 2013/10/15/ PY - 2013/05/22/received PY - 2013/10/04/accepted PY - 2013/10/16/entrez PY - 2013/10/16/pubmed PY - 2014/10/15/medline SP - 315 EP - 25 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 121 IS - 3 N2 - The N100 component, evoked by transcranial magnetic stimulation (TMS) and electroencephalography is associated with the activation of inhibitory cortical circuits and has recently been suggested as a potential marker of inhibition in attention-deficit/hyperactivity disorder (ADHD). The aim of the present ADHD study was to investigate the modulation of the TMS-N100 in go and nogo trials of a response control task considering stages of response preparation, activation, execution and inhibition. Eighteen children with ADHD and 19 typically developing children, aged 10-14 years, were assessed. TMS was delivered over the left motor cortex, the TMS-N100 was measured at electrode P3. The TMS-N100 was determined at rest and at different time points (50 ms before S2; 150, 300 and 500 ms after S2) in a cued go/nogo task (S1-S2 paradigm). Correlations between the TMS-N100 measures, MEP-related TMS measures (e.g., short-interval intracortical inhibition) and performance measures were calculated. At rest, the amplitude of TMS-N100 was not found to be significantly reduced in the ADHD group. During the go/nogo task, children with ADHD showed a smaller increase of TMS-N100 amplitude in go trials and a smaller decrease after inhibiting a response. In go trials, a lower TMS-N100 was associated with a smaller variability of reaction times. A smaller TMS-N100 modulation extends the picture of cortical inhibition deficits in ADHD. Findings suggest a functional involvement of the mechanisms underlying the TMS-N100 at the motor output stage. SN - 1435-1463 UR - https://www.unboundmedicine.com/medline/citation/24126573/Motor_cortical_inhibition_in_ADHD:_modulation_of_the_transcranial_magnetic_stimulation_evoked_N100_in_a_response_control_task_ L2 - https://dx.doi.org/10.1007/s00702-013-1097-7 DB - PRIME DP - Unbound Medicine ER -