Tags

Type your tag names separated by a space and hit enter

Treatment outcomes of injection laryngoplasty using cross-linked porcine collagen and hyaluronic acid.
Otolaryngol Head Neck Surg. 2013 Dec; 149(6):900-6.OH

Abstract

OBJECTIVE

To investigate the treatment outcomes and prognostic factors of injection laryngoplasty (IL) using cross-linked porcine collagen (PC) and hyaluronic acid (HA) in unilateral vocal fold paralysis (UVFP).

STUDY DESIGN

Case series with chart review.

SETTING

A tertiary teaching hospital.

SUBJECTS AND METHODS

This study reviewed 60 consecutive patients with UVFP who underwent IL with PC (n = 33) or HA (n = 27). Objective evaluations included maximal phonation time (MPT) and 10-item voice handicap index (VHI-10). Kaplan-Meier method was applied to evaluate the subjective treatment outcomes according to the patients' self-assessment of symptom recurrence via chart review for the follow-up period of 15 months. Log-rank tests were applied to evaluate the association between clinical factors and subjective treatment outcomes.

RESULTS

Objective outcome measurements revealed significantly improved MPT and VHI-10 at 1, 3, and 6 months posttreatment, with nonsignificant differences between the PC and HA groups. Subjective treatment outcomes also revealed a nonsignificant difference between the 2 groups. The median symptom-free durations were 10.9 and 14.4 months for the PC and HA groups, respectively. Subsequent analyses failed to identify prognostic significance of sex, time to treatment, etiology, side, injection approaches, and the presence of aspiration. No significant adverse effects occurred during the follow-up period.

CONCLUSION

This study demonstrated comparable subjective and objective improvements following IL using PC or HA in patients with UVFP. No significant prognostic factor of IL was discovered in the present research. Porcine collagen and HA as medium duration materials might play a role in the future of IL.

Authors+Show Affiliations

Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24128900

Citation

Wen, Ming-Hsun, et al. "Treatment Outcomes of Injection Laryngoplasty Using Cross-linked Porcine Collagen and Hyaluronic Acid." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 149, no. 6, 2013, pp. 900-6.
Wen MH, Cheng PW, Liao LJ, et al. Treatment outcomes of injection laryngoplasty using cross-linked porcine collagen and hyaluronic acid. Otolaryngol Head Neck Surg. 2013;149(6):900-6.
Wen, M. H., Cheng, P. W., Liao, L. J., Chou, H. W., & Wang, C. T. (2013). Treatment outcomes of injection laryngoplasty using cross-linked porcine collagen and hyaluronic acid. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 149(6), 900-6. https://doi.org/10.1177/0194599813508082
Wen MH, et al. Treatment Outcomes of Injection Laryngoplasty Using Cross-linked Porcine Collagen and Hyaluronic Acid. Otolaryngol Head Neck Surg. 2013;149(6):900-6. PubMed PMID: 24128900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment outcomes of injection laryngoplasty using cross-linked porcine collagen and hyaluronic acid. AU - Wen,Ming-Hsun, AU - Cheng,Po-Wen, AU - Liao,Li-Jen, AU - Chou,Hsu-Wen, AU - Wang,Chi-Te, Y1 - 2013/10/15/ PY - 2013/10/17/entrez PY - 2013/10/17/pubmed PY - 2014/2/6/medline KW - augmentation KW - hyaluronan KW - larynx KW - medialization KW - vocal fold SP - 900 EP - 6 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 149 IS - 6 N2 - OBJECTIVE: To investigate the treatment outcomes and prognostic factors of injection laryngoplasty (IL) using cross-linked porcine collagen (PC) and hyaluronic acid (HA) in unilateral vocal fold paralysis (UVFP). STUDY DESIGN: Case series with chart review. SETTING: A tertiary teaching hospital. SUBJECTS AND METHODS: This study reviewed 60 consecutive patients with UVFP who underwent IL with PC (n = 33) or HA (n = 27). Objective evaluations included maximal phonation time (MPT) and 10-item voice handicap index (VHI-10). Kaplan-Meier method was applied to evaluate the subjective treatment outcomes according to the patients' self-assessment of symptom recurrence via chart review for the follow-up period of 15 months. Log-rank tests were applied to evaluate the association between clinical factors and subjective treatment outcomes. RESULTS: Objective outcome measurements revealed significantly improved MPT and VHI-10 at 1, 3, and 6 months posttreatment, with nonsignificant differences between the PC and HA groups. Subjective treatment outcomes also revealed a nonsignificant difference between the 2 groups. The median symptom-free durations were 10.9 and 14.4 months for the PC and HA groups, respectively. Subsequent analyses failed to identify prognostic significance of sex, time to treatment, etiology, side, injection approaches, and the presence of aspiration. No significant adverse effects occurred during the follow-up period. CONCLUSION: This study demonstrated comparable subjective and objective improvements following IL using PC or HA in patients with UVFP. No significant prognostic factor of IL was discovered in the present research. Porcine collagen and HA as medium duration materials might play a role in the future of IL. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/24128900/Treatment_outcomes_of_injection_laryngoplasty_using_cross_linked_porcine_collagen_and_hyaluronic_acid_ L2 - http://journals.sagepub.com/doi/full/10.1177/0194599813508082?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -