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Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis.
Ocul Immunol Inflamm. 2014 Jun; 22(3):208-12.OI

Abstract

PURPOSE

Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and is associated with considerable morbidity. The aim of this study was to examine the risk factors associated with uveitis in oligoarticular JIA.

METHODS

We conducted a chart review of 86 patients with oligoarticular JIA to assess if antinuclear antibody (ANA) status, gender, and age at JIA onset were associated with the development of uveitis. Biomarkers such as cytokine gene polymorphisms, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were also assessed.

RESULTS

Twenty-seven patients exhibited oligoarticular JIA-associated uveitis. Only the ESR at arthritis onset and the patient's age at arthritis onset were related to uveitis development in our patient sample.

CONCLUSIONS

An age-associated risk of uveitis was observed in children younger than 3 years at the time of JIA onset. ESR values at arthritis onset higher than 22 mm/h were also related to uveitis development.

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Authors+Show Affiliations

Pelegrín L
Instituto Clínic de Oftalmologia, Hospital Clínico , Barcelona , Spain .
Casaroli-Marano R
No affiliation info available
Antón J
No affiliation info available
García de Vicuña MC
No affiliation info available
Molina-Prat N
No affiliation info available
Ignacio Aróstegui J
No affiliation info available
Yagüe J
No affiliation info available
Ríos J
No affiliation info available
Adán A
No affiliation info available

MeSH

Age of OnsetAntibodies, AntinuclearArthritis, JuvenileBiomarkersBlood SedimentationC-Reactive ProteinChild, PreschoolCross-Sectional StudiesCytokinesDNAFemaleFollow-Up StudiesHumansIncidenceMalePolymerase Chain ReactionPolymorphism, GeneticPredictive Value of TestsPrognosisRisk FactorsSpainUveitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24131380

Citation

Pelegrín, Laura, et al. "Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis." Ocular Immunology and Inflammation, vol. 22, no. 3, 2014, pp. 208-12.
Pelegrín L, Casaroli-Marano R, Antón J, et al. Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis. Ocul Immunol Inflamm. 2014;22(3):208-12.
Pelegrín, L., Casaroli-Marano, R., Antón, J., García de Vicuña, M. C., Molina-Prat, N., Ignacio Aróstegui, J., Yagüe, J., Ríos, J., & Adán, A. (2014). Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis. Ocular Immunology and Inflammation, 22(3), 208-12. https://doi.org/10.3109/09273948.2013.841495
Pelegrín L, et al. Predictive Value of Selected Biomarkers, Polymorphisms, and Clinical Features for Oligoarticular Juvenile Idiopathic Arthritis-associated Uveitis. Ocul Immunol Inflamm. 2014;22(3):208-12. PubMed PMID: 24131380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis. AU - Pelegrín,Laura, AU - Casaroli-Marano,Ricardo, AU - Antón,Jordi, AU - García de Vicuña,María Carmen, AU - Molina-Prat,Nicolás, AU - Ignacio Aróstegui,Juan, AU - Yagüe,Jordi, AU - Ríos,José, AU - Adán,Alfredo, Y1 - 2013/10/16/ PY - 2013/10/18/entrez PY - 2013/10/18/pubmed PY - 2015/1/21/medline KW - Age of arthritis onset KW - chronic anterior uveitis KW - erythrocyte sedimentation rate KW - oligoarticular juvenile idiopathic arthritis KW - polymorphism SP - 208 EP - 12 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 22 IS - 3 N2 - PURPOSE: Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and is associated with considerable morbidity. The aim of this study was to examine the risk factors associated with uveitis in oligoarticular JIA. METHODS: We conducted a chart review of 86 patients with oligoarticular JIA to assess if antinuclear antibody (ANA) status, gender, and age at JIA onset were associated with the development of uveitis. Biomarkers such as cytokine gene polymorphisms, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were also assessed. RESULTS: Twenty-seven patients exhibited oligoarticular JIA-associated uveitis. Only the ESR at arthritis onset and the patient's age at arthritis onset were related to uveitis development in our patient sample. CONCLUSIONS: An age-associated risk of uveitis was observed in children younger than 3 years at the time of JIA onset. ESR values at arthritis onset higher than 22 mm/h were also related to uveitis development. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/24131380/Predictive_value_of_selected_biomarkers_polymorphisms_and_clinical_features_for_oligoarticular_juvenile_idiopathic_arthritis_associated_uveitis_ L2 - https://www.tandfonline.com/doi/full/10.3109/09273948.2013.841495 DB - PRIME DP - Unbound Medicine ER -