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Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study.
Hypertens Res. 2014 Jan; 37(1):82-7.HR

Abstract

To analyze the clinical significance of the oral glucose tolerance test (OGTT) in the assessment of abnormal glucose metabolism in Chinese patients with hypertension. In this cross-sectional study of 10,173 hypertensive adult patients from eight sites in China, data on patient, clinical and disease characteristics were collected, and fasting plasma glucose (FPG) levels were measured. A subset of 5322 patients also underwent an OGTT. Abnormal glucose metabolism (impaired glucose regulation (IGR) or diabetes mellitus (DM)) was detected in 31.1% of the 10,173 patients by FPG testing and in 67% of the 5322 patients by OGTT. OGTT increased the detection rate by 35.8%. Patients with FPG levels ≥5.6 and ≥6.1 mmol l(-1) had the mean OGTT 2-h plasma glucose levels of 8.79 and 9.68 mmol l(-1), respectively. Compared with normoglycemic patients, those with IGR or DM had higher rates of total proteinuria (normoglycemic 15.8% vs. IGR 22.1% vs. DM 33.7%, P<0.001), a lower absolute estimated glomerular filtration rate (eGFR; in ml min(-1) per 1.73 m(2)) (82.9 vs. 80.77 vs. 79.74, P=0.06) and a higher prevalence of cardiovascular disease (normoglycemic 17.6% vs. IGR/DM 13.8%, P<0.001). Abnormal abdominal circumference, eGFR ≤60 ml min(-1) per 1.73 m(2), and proteinuria were independently associated with abnormal glucose metabolism (IGR or DM). Hypertensive patients who are diabetic or at risk of diabetes are at greater risk of renal damage and cardiovascular disease than those who are normoglycemic. It is insufficient to assess the glucose metabolism status of Chinese hypertensive patients using only FPG testing; the use of OGTT can increase the detection rate by 35.8%. Patients whose FPG levels were <5.6 mmol l(-1) may be found to have abnormal glucose metabolism after an OGTT.

Authors+Show Affiliations

Heart Center, Peking University People's Hospital, Beijing, China.Heart Center, Peking University People's Hospital, Beijing, China.Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.Department of Hypertension, Henan Provincial People's Hospital, Zhengzhou, China.Department of Cardiology, Tangdu Hospital of The Fourth Military Medical University, Chongqing, China.Department of Cardiology, Daqing Oilfield General Hospital of Heilongjiang Province, Daqing, China.Department of Hypertension and endocrinology, Daping Hospital of Chongqing, Chongqing, China.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24132011

Citation

Sun, Ningling, et al. "Detecting Diabetic Risk Using the Oral Glucose Tolerance Test in Chinese Patients With Hypertension: a Cross-sectional Study." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 37, no. 1, 2014, pp. 82-7.
Sun N, Wang H, Sun Y, et al. Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study. Hypertens Res. 2014;37(1):82-7.
Sun, N., Wang, H., Sun, Y., Chen, X., Wang, H., Zhao, L., Wang, J., & Zhu, Z. (2014). Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 37(1), 82-7. https://doi.org/10.1038/hr.2013.126
Sun N, et al. Detecting Diabetic Risk Using the Oral Glucose Tolerance Test in Chinese Patients With Hypertension: a Cross-sectional Study. Hypertens Res. 2014;37(1):82-7. PubMed PMID: 24132011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detecting diabetic risk using the oral glucose tolerance test in Chinese patients with hypertension: a cross-sectional study. AU - Sun,Ningling, AU - Wang,Hongyi, AU - Sun,Yuemin, AU - Chen,Xiaoping, AU - Wang,Hao, AU - Zhao,Lianyou, AU - Wang,Jinping, AU - Zhu,Zhiming, Y1 - 2013/10/17/ PY - 2013/01/21/received PY - 2013/05/29/revised PY - 2013/06/28/accepted PY - 2013/10/18/entrez PY - 2013/10/18/pubmed PY - 2014/8/26/medline SP - 82 EP - 7 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 37 IS - 1 N2 - To analyze the clinical significance of the oral glucose tolerance test (OGTT) in the assessment of abnormal glucose metabolism in Chinese patients with hypertension. In this cross-sectional study of 10,173 hypertensive adult patients from eight sites in China, data on patient, clinical and disease characteristics were collected, and fasting plasma glucose (FPG) levels were measured. A subset of 5322 patients also underwent an OGTT. Abnormal glucose metabolism (impaired glucose regulation (IGR) or diabetes mellitus (DM)) was detected in 31.1% of the 10,173 patients by FPG testing and in 67% of the 5322 patients by OGTT. OGTT increased the detection rate by 35.8%. Patients with FPG levels ≥5.6 and ≥6.1 mmol l(-1) had the mean OGTT 2-h plasma glucose levels of 8.79 and 9.68 mmol l(-1), respectively. Compared with normoglycemic patients, those with IGR or DM had higher rates of total proteinuria (normoglycemic 15.8% vs. IGR 22.1% vs. DM 33.7%, P<0.001), a lower absolute estimated glomerular filtration rate (eGFR; in ml min(-1) per 1.73 m(2)) (82.9 vs. 80.77 vs. 79.74, P=0.06) and a higher prevalence of cardiovascular disease (normoglycemic 17.6% vs. IGR/DM 13.8%, P<0.001). Abnormal abdominal circumference, eGFR ≤60 ml min(-1) per 1.73 m(2), and proteinuria were independently associated with abnormal glucose metabolism (IGR or DM). Hypertensive patients who are diabetic or at risk of diabetes are at greater risk of renal damage and cardiovascular disease than those who are normoglycemic. It is insufficient to assess the glucose metabolism status of Chinese hypertensive patients using only FPG testing; the use of OGTT can increase the detection rate by 35.8%. Patients whose FPG levels were <5.6 mmol l(-1) may be found to have abnormal glucose metabolism after an OGTT. SN - 1348-4214 UR - https://www.unboundmedicine.com/medline/citation/24132011/Detecting_diabetic_risk_using_the_oral_glucose_tolerance_test_in_Chinese_patients_with_hypertension:_a_cross_sectional_study_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -