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Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood.
JAMA Psychiatry. 2013 Dec; 70(12):1329-37.JP

Abstract

IMPORTANCE

The neurobiological underpinnings of attention-deficit/hyperactivity disorder (ADHD) and particularly those associated with the persistence of ADHD into adulthood are not yet well understood. The correlation patterns in spontaneous neural fluctuations at rest are known as resting-state functional connectivity (RSFC) and could characterize ADHD-specific connectivity changes.

OBJECTIVE

To determine the specific location of possible ADHD-related differences in RSFC between adults diagnosed as having ADHD in childhood and control subjects. DESIGN Using resting-state functional magnetic resonance imaging, we calculated and compared functional connectivity from attention, affective, default, and cognitive control networks involved in the psychopathology of ADHD between the ADHD and control groups. SETTING University psychiatric service and magnetic resonance imaging research center.

PARTICIPANTS

Sixteen drug-free adults (5 women and 11 men; mean age, 24.5 years) diagnosed with combined-type ADHD in childhood and 16 healthy controls matched for age (mean age, 24.4 years), sex, handedness, and educational level recruited from the community.

INTERVENTION

Functional magnetic resonance imaging.

MAIN OUTCOMES AND MEASURES

Connectivity data from ventral and dorsal attention, affective, default, and cognitive control networks and ADHD symptoms derived from ADHD-specific rating instruments.

RESULTS

Adults with ADHD showed significantly decreased RSFC within the attention networks and increased RSFC within the affective and default mode and the right lateralized cognitive control networks compared with healthy controls (P < .01, familywise error for whole-brain cluster correction). Lower RSFC in the ventral and dorsal attention network was significantly correlated with higher levels of ADHD symptoms (P < .001).

CONCLUSIONS AND RELEVANCE

These RSFC findings might underpin a biological basis for adult ADHD and are functionally related to persistent inattention, disturbance in cognitive control, and emotional dysregulation in adults with ADHD. These findings need to be understood in the context of all aspects of brain function in ADHD.

Authors+Show Affiliations

Neuroimaging Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland2Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24132732

Citation

McCarthy, Hazel, et al. "Attention Network Hypoconnectivity With Default and Affective Network Hyperconnectivity in Adults Diagnosed With Attention-deficit/hyperactivity Disorder in Childhood." JAMA Psychiatry, vol. 70, no. 12, 2013, pp. 1329-37.
McCarthy H, Skokauskas N, Mulligan A, et al. Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood. JAMA Psychiatry. 2013;70(12):1329-37.
McCarthy, H., Skokauskas, N., Mulligan, A., Donohoe, G., Mullins, D., Kelly, J., Johnson, K., Fagan, A., Gill, M., Meaney, J., & Frodl, T. (2013). Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood. JAMA Psychiatry, 70(12), 1329-37. https://doi.org/10.1001/jamapsychiatry.2013.2174
McCarthy H, et al. Attention Network Hypoconnectivity With Default and Affective Network Hyperconnectivity in Adults Diagnosed With Attention-deficit/hyperactivity Disorder in Childhood. JAMA Psychiatry. 2013;70(12):1329-37. PubMed PMID: 24132732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood. AU - McCarthy,Hazel, AU - Skokauskas,Norbert, AU - Mulligan,Aisling, AU - Donohoe,Gary, AU - Mullins,Diane, AU - Kelly,John, AU - Johnson,Katherine, AU - Fagan,Andrew, AU - Gill,Michael, AU - Meaney,James, AU - Frodl,Thomas, PY - 2013/10/18/entrez PY - 2013/10/18/pubmed PY - 2014/2/25/medline SP - 1329 EP - 37 JF - JAMA psychiatry JO - JAMA Psychiatry VL - 70 IS - 12 N2 - IMPORTANCE: The neurobiological underpinnings of attention-deficit/hyperactivity disorder (ADHD) and particularly those associated with the persistence of ADHD into adulthood are not yet well understood. The correlation patterns in spontaneous neural fluctuations at rest are known as resting-state functional connectivity (RSFC) and could characterize ADHD-specific connectivity changes. OBJECTIVE: To determine the specific location of possible ADHD-related differences in RSFC between adults diagnosed as having ADHD in childhood and control subjects. DESIGN Using resting-state functional magnetic resonance imaging, we calculated and compared functional connectivity from attention, affective, default, and cognitive control networks involved in the psychopathology of ADHD between the ADHD and control groups. SETTING University psychiatric service and magnetic resonance imaging research center. PARTICIPANTS: Sixteen drug-free adults (5 women and 11 men; mean age, 24.5 years) diagnosed with combined-type ADHD in childhood and 16 healthy controls matched for age (mean age, 24.4 years), sex, handedness, and educational level recruited from the community. INTERVENTION: Functional magnetic resonance imaging. MAIN OUTCOMES AND MEASURES: Connectivity data from ventral and dorsal attention, affective, default, and cognitive control networks and ADHD symptoms derived from ADHD-specific rating instruments. RESULTS: Adults with ADHD showed significantly decreased RSFC within the attention networks and increased RSFC within the affective and default mode and the right lateralized cognitive control networks compared with healthy controls (P < .01, familywise error for whole-brain cluster correction). Lower RSFC in the ventral and dorsal attention network was significantly correlated with higher levels of ADHD symptoms (P < .001). CONCLUSIONS AND RELEVANCE: These RSFC findings might underpin a biological basis for adult ADHD and are functionally related to persistent inattention, disturbance in cognitive control, and emotional dysregulation in adults with ADHD. These findings need to be understood in the context of all aspects of brain function in ADHD. SN - 2168-6238 UR - https://www.unboundmedicine.com/medline/citation/24132732/Attention_network_hypoconnectivity_with_default_and_affective_network_hyperconnectivity_in_adults_diagnosed_with_attention_deficit/hyperactivity_disorder_in_childhood_ L2 - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2013.2174 DB - PRIME DP - Unbound Medicine ER -