Tags

Type your tag names separated by a space and hit enter

A nationwide population-based retrospective cohort study: increased risk of acute coronary syndrome in patients with ankylosing spondylitis.
Scand J Rheumatol. 2014; 43(2):132-6.SJ

Abstract

OBJECTIVES

To compare the risk of acute coronary syndrome (ACS) between patients with and without ankylosing spondylitis (AS).

METHOD

This retrospective cohort study identified all patients with AS aged ≥ 18 years newly diagnosed from 2000 to 2009, registered in the National Health Insurance Research Database (NHIRD) in Taiwan. The non-AS cohort consisted of fourfold randomly selected control patients free of AS, frequency matched by age, sex, and diagnosis year. The incidence of ACS was determined for both AS and non-AS cohorts.

RESULTS

We selected 6262 patients with AS and 25 048 patients without AS. The patients with AS were more prevalent than those without, with co-morbidities of hypertension, diabetes mellitus (DM), hyperlipidaemia, stroke, and peripheral vascular diseases. The overall incidence rate of ACS was higher in the AS cohort than in the non-AS cohort (4.4 vs. 2.9 per 1000 person-years), with an adjusted hazard ratio (aHR) of 1.36 [95% confidence interval (CI) 1.16-1.59]. AS patients with co-morbidities of hypertension, DM, and cancer had an aHR of 7.74 for ACS, compared to those without these co-morbidities.

CONCLUSIONS

AS patients are at higher risk of ACS compared with non-AS subjects. Management of CV risk factors should be taken into account for the treatment of patients with AS, especially for patients with co-morbidities of hypertension, DM, and cancer.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, YuanSheng Hospital and Changhua Christian Hospital, Yunlin Branch , Yunlin , Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24134400

Citation

Chou, C-H, et al. "A Nationwide Population-based Retrospective Cohort Study: Increased Risk of Acute Coronary Syndrome in Patients With Ankylosing Spondylitis." Scandinavian Journal of Rheumatology, vol. 43, no. 2, 2014, pp. 132-6.
Chou CH, Lin MC, Peng CL, et al. A nationwide population-based retrospective cohort study: increased risk of acute coronary syndrome in patients with ankylosing spondylitis. Scand J Rheumatol. 2014;43(2):132-6.
Chou, C. H., Lin, M. C., Peng, C. L., Wu, Y. C., Sung, F. C., Kao, C. H., & Liu, S. H. (2014). A nationwide population-based retrospective cohort study: increased risk of acute coronary syndrome in patients with ankylosing spondylitis. Scandinavian Journal of Rheumatology, 43(2), 132-6. https://doi.org/10.3109/03009742.2013.822097
Chou CH, et al. A Nationwide Population-based Retrospective Cohort Study: Increased Risk of Acute Coronary Syndrome in Patients With Ankylosing Spondylitis. Scand J Rheumatol. 2014;43(2):132-6. PubMed PMID: 24134400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nationwide population-based retrospective cohort study: increased risk of acute coronary syndrome in patients with ankylosing spondylitis. AU - Chou,C-H, AU - Lin,M-C, AU - Peng,C-L, AU - Wu,Y-C, AU - Sung,F-C, AU - Kao,C-H, AU - Liu,S-H, Y1 - 2013/10/18/ PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2014/5/28/medline SP - 132 EP - 6 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 43 IS - 2 N2 - OBJECTIVES: To compare the risk of acute coronary syndrome (ACS) between patients with and without ankylosing spondylitis (AS). METHOD: This retrospective cohort study identified all patients with AS aged ≥ 18 years newly diagnosed from 2000 to 2009, registered in the National Health Insurance Research Database (NHIRD) in Taiwan. The non-AS cohort consisted of fourfold randomly selected control patients free of AS, frequency matched by age, sex, and diagnosis year. The incidence of ACS was determined for both AS and non-AS cohorts. RESULTS: We selected 6262 patients with AS and 25 048 patients without AS. The patients with AS were more prevalent than those without, with co-morbidities of hypertension, diabetes mellitus (DM), hyperlipidaemia, stroke, and peripheral vascular diseases. The overall incidence rate of ACS was higher in the AS cohort than in the non-AS cohort (4.4 vs. 2.9 per 1000 person-years), with an adjusted hazard ratio (aHR) of 1.36 [95% confidence interval (CI) 1.16-1.59]. AS patients with co-morbidities of hypertension, DM, and cancer had an aHR of 7.74 for ACS, compared to those without these co-morbidities. CONCLUSIONS: AS patients are at higher risk of ACS compared with non-AS subjects. Management of CV risk factors should be taken into account for the treatment of patients with AS, especially for patients with co-morbidities of hypertension, DM, and cancer. SN - 1502-7732 UR - https://www.unboundmedicine.com/medline/citation/24134400/A_nationwide_population_based_retrospective_cohort_study:_increased_risk_of_acute_coronary_syndrome_in_patients_with_ankylosing_spondylitis_ L2 - http://www.tandfonline.com/doi/full/10.3109/03009742.2013.822097 DB - PRIME DP - Unbound Medicine ER -