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In vitro activities of antifungal drugs against dermatophytes isolated in Tokat, Turkey.
Int J Dermatol. 2013 Dec; 52(12):1557-60.IJ

Abstract

BACKGROUND

In this study, we aimed to establish the in vitro antifungal susceptibilities of terbinafine, miconazole, itraconazole, ketoconazole, griseofulvin, and amphotericin B against dermatophyte isolates.

METHODS

One hundred and seventy-seven clinical isolates were tested: Trichophyton rubrum (n = 78), Trichophyton mentagrophytes (n = 49), Epidermophyton floccosum (n = 30), Trichophyton verrucosum (n = 16), and Trichophyton tonsurans (n = 4). The broth microdilution assay for antifungal susceptibility testing of dermatophytes was performed according to Clinical and Laboratory Standards Institute guidelines in the M38-A2 document.

RESULTS

Our minimum inhibitory concentration (MIC) results showed that the values for terbinafine for all dermatophyte isolates were significantly lower than the values for amphotericin B, miconazole, itraconazole, ketoconazole, and griseofulvin. For T. rubrum isolates, amphotericin B was more active than miconazole, itraconazole, and ketoconazole. Among the antifungal drugs tested, griseofulvin had the highest minimum inhibitory concentration values for T. mentagrophytes isolates.

CONCLUSION

Terbinafine was found to be the most effective antifungal drug against all tested dermatophyte isolates. Griseofulvin was the less active antifungal drug against T. mentagrophytes isolates. Performing antifungal susceptibility testing is especially important for screening the development of antifungal resistance.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yenişehirli G
Departments of Microbiology and Clinical Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
Tunçoğlu E
No affiliation info available
Yenişehirli A
No affiliation info available
Bulut Y
No affiliation info available

MeSH

Amphotericin BAntifungal AgentsArthrodermataceaeDrug Resistance, FungalEpidermophytonGriseofulvinHumansIn Vitro TechniquesItraconazoleKetoconazoleMicrobial Sensitivity TestsNaphthalenesTerbinafineTrichophytonTurkey

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24134487

Citation

Yenişehirli, Gülgün, et al. "In Vitro Activities of Antifungal Drugs Against Dermatophytes Isolated in Tokat, Turkey." International Journal of Dermatology, vol. 52, no. 12, 2013, pp. 1557-60.
Yenişehirli G, Tunçoğlu E, Yenişehirli A, et al. In vitro activities of antifungal drugs against dermatophytes isolated in Tokat, Turkey. Int J Dermatol. 2013;52(12):1557-60.
Yenişehirli, G., Tunçoğlu, E., Yenişehirli, A., & Bulut, Y. (2013). In vitro activities of antifungal drugs against dermatophytes isolated in Tokat, Turkey. International Journal of Dermatology, 52(12), 1557-60. https://doi.org/10.1111/ijd.12100
Yenişehirli G, et al. In Vitro Activities of Antifungal Drugs Against Dermatophytes Isolated in Tokat, Turkey. Int J Dermatol. 2013;52(12):1557-60. PubMed PMID: 24134487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activities of antifungal drugs against dermatophytes isolated in Tokat, Turkey. AU - Yenişehirli,Gülgün, AU - Tunçoğlu,Ebru, AU - Yenişehirli,Aydan, AU - Bulut,Yunus, Y1 - 2013/10/18/ PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2014/8/13/medline SP - 1557 EP - 60 JF - International journal of dermatology JO - Int J Dermatol VL - 52 IS - 12 N2 - BACKGROUND: In this study, we aimed to establish the in vitro antifungal susceptibilities of terbinafine, miconazole, itraconazole, ketoconazole, griseofulvin, and amphotericin B against dermatophyte isolates. METHODS: One hundred and seventy-seven clinical isolates were tested: Trichophyton rubrum (n = 78), Trichophyton mentagrophytes (n = 49), Epidermophyton floccosum (n = 30), Trichophyton verrucosum (n = 16), and Trichophyton tonsurans (n = 4). The broth microdilution assay for antifungal susceptibility testing of dermatophytes was performed according to Clinical and Laboratory Standards Institute guidelines in the M38-A2 document. RESULTS: Our minimum inhibitory concentration (MIC) results showed that the values for terbinafine for all dermatophyte isolates were significantly lower than the values for amphotericin B, miconazole, itraconazole, ketoconazole, and griseofulvin. For T. rubrum isolates, amphotericin B was more active than miconazole, itraconazole, and ketoconazole. Among the antifungal drugs tested, griseofulvin had the highest minimum inhibitory concentration values for T. mentagrophytes isolates. CONCLUSION: Terbinafine was found to be the most effective antifungal drug against all tested dermatophyte isolates. Griseofulvin was the less active antifungal drug against T. mentagrophytes isolates. Performing antifungal susceptibility testing is especially important for screening the development of antifungal resistance. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/24134487/In_vitro_activities_of_antifungal_drugs_against_dermatophytes_isolated_in_Tokat_Turkey_ DB - PRIME DP - Unbound Medicine ER -