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Prospective study of maternal mid-pregnancy 25-hydroxyvitamin D level and early childhood respiratory disorders.
Paediatr Perinat Epidemiol. 2013 Nov; 27(6):532-41.PP

Abstract

BACKGROUND

Studies suggest that prenatal vitamin D status may be inversely associated with lower respiratory tract infections (LRTIs) early in life. Studies of prenatal vitamin D status and development of asthma have inconsistent findings.

METHODS

We examined the associations of maternal mid-pregnancy 25-hydroxyvitamin D [25(OH)D] level with the frequency of LRTIs by 36 months and with current asthma at 36 months using the Norwegian Mother and Child Cohort Study. Maternal plasma 25(OH)D level was measured using liquid chromatography-tandem mass spectrometry. Respiratory disorders were evaluated by maternal report through questionnaires. LRTIs were analysed in a random sample of 1248 children. Asthma was analysed using a case-control design, including 489 cases and 1183 controls. Multivariable generalised linear models calculated adjusted measures of association.

RESULTS

The median gestational week of sample collection was 18 weeks (range 9, 35). The mean 25(OH)D level was 73.7 nmol/L (standard deviation 23.7). Higher maternal mid-pregnancy 25(OH)D level was associated with a reduced risk of three or more LRTIs by 36 months vs. none, adjusted risk ratio 0.74 [95% confidence interval (CI): 0.58, 0.93] per 20 nmol/L increase. Associations were similar when examining the frequency of LRTIs by 18 months, and the frequency of LRTIs between 18 and 36 months. Maternal mid-pregnancy 25(OH)D level was not significantly associated with current asthma at 36 months, adjusted odds ratio 0.91 [95% CI 0.81, 1.02] per 20 nmol/L increase.

CONCLUSIONS

Higher maternal mid-pregnancy 25(OH)D level was associated with a modestly reduced risk of recurrent LRTIs by 36 months, but was not associated with current asthma at 36 months.

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Authors+Show Affiliations

Magnus MC
Department of Chronic Diseases, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Stene LC
No affiliation info available
Håberg SE
No affiliation info available
Nafstad P
No affiliation info available
Stigum H
No affiliation info available
London SJ
No affiliation info available
Nystad W
No affiliation info available

MeSH

AdultAsthmaCase-Control StudiesChildChromatography, LiquidFemaleHumansNorwayPregnancyProspective StudiesRespiratory Tract InfectionsRisk FactorsSurveys and QuestionnairesTandem Mass SpectrometryVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24134527

Citation

Magnus, Maria C., et al. "Prospective Study of Maternal Mid-pregnancy 25-hydroxyvitamin D Level and Early Childhood Respiratory Disorders." Paediatric and Perinatal Epidemiology, vol. 27, no. 6, 2013, pp. 532-41.
Magnus MC, Stene LC, Håberg SE, et al. Prospective study of maternal mid-pregnancy 25-hydroxyvitamin D level and early childhood respiratory disorders. Paediatr Perinat Epidemiol. 2013;27(6):532-41.
Magnus, M. C., Stene, L. C., Håberg, S. E., Nafstad, P., Stigum, H., London, S. J., & Nystad, W. (2013). Prospective study of maternal mid-pregnancy 25-hydroxyvitamin D level and early childhood respiratory disorders. Paediatric and Perinatal Epidemiology, 27(6), 532-41. https://doi.org/10.1111/ppe.12080
Magnus MC, et al. Prospective Study of Maternal Mid-pregnancy 25-hydroxyvitamin D Level and Early Childhood Respiratory Disorders. Paediatr Perinat Epidemiol. 2013;27(6):532-41. PubMed PMID: 24134527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of maternal mid-pregnancy 25-hydroxyvitamin D level and early childhood respiratory disorders. AU - Magnus,Maria C, AU - Stene,Lars C, AU - Håberg,Siri E, AU - Nafstad,Per, AU - Stigum,Hein, AU - London,Stephanie J, AU - Nystad,Wenche, Y1 - 2013/08/20/ PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2014/7/18/medline KW - asthma KW - lower respiratory tract infection KW - pregnancy KW - vitamin D SP - 532 EP - 41 JF - Paediatric and perinatal epidemiology JO - Paediatr Perinat Epidemiol VL - 27 IS - 6 N2 - BACKGROUND: Studies suggest that prenatal vitamin D status may be inversely associated with lower respiratory tract infections (LRTIs) early in life. Studies of prenatal vitamin D status and development of asthma have inconsistent findings. METHODS: We examined the associations of maternal mid-pregnancy 25-hydroxyvitamin D [25(OH)D] level with the frequency of LRTIs by 36 months and with current asthma at 36 months using the Norwegian Mother and Child Cohort Study. Maternal plasma 25(OH)D level was measured using liquid chromatography-tandem mass spectrometry. Respiratory disorders were evaluated by maternal report through questionnaires. LRTIs were analysed in a random sample of 1248 children. Asthma was analysed using a case-control design, including 489 cases and 1183 controls. Multivariable generalised linear models calculated adjusted measures of association. RESULTS: The median gestational week of sample collection was 18 weeks (range 9, 35). The mean 25(OH)D level was 73.7 nmol/L (standard deviation 23.7). Higher maternal mid-pregnancy 25(OH)D level was associated with a reduced risk of three or more LRTIs by 36 months vs. none, adjusted risk ratio 0.74 [95% confidence interval (CI): 0.58, 0.93] per 20 nmol/L increase. Associations were similar when examining the frequency of LRTIs by 18 months, and the frequency of LRTIs between 18 and 36 months. Maternal mid-pregnancy 25(OH)D level was not significantly associated with current asthma at 36 months, adjusted odds ratio 0.91 [95% CI 0.81, 1.02] per 20 nmol/L increase. CONCLUSIONS: Higher maternal mid-pregnancy 25(OH)D level was associated with a modestly reduced risk of recurrent LRTIs by 36 months, but was not associated with current asthma at 36 months. SN - 1365-3016 UR - https://www.unboundmedicine.com/medline/citation/24134527/Prospective_study_of_maternal_mid_pregnancy_25_hydroxyvitamin_D_level_and_early_childhood_respiratory_disorders_ L2 - https://doi.org/10.1111/ppe.12080 DB - PRIME DP - Unbound Medicine ER -