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The relationship between the phenotype of Parkinson's disease and levodopa-induced dyskinesia.
Neurosci Lett. 2013 Nov 27; 556:109-12.NL

Abstract

Levodopa has been demonstrated to be an effective medication for Parkinson's disease (PD), but its long-term use is complicated by the subsequent development of dyskinesias. Few studies have distinguished distinct PD subtypes associated with the occurrence of Levodopa-Induced Dyskinesia (LID). Therefore, we performed a retrospective analysis to determine if the specific phenotype of PD and other epidemiological factors are associated with the development of LID. Of 367 PD patients taking levodopa, 101 of them developed LID. Multivariate logistic regression analysis demonstrated that initial tremor-dominant manifestation was associated with a reduced risk of LID, independent of other risk factors, such as age at the onset of PD, the duration and dose of levodopa.

Authors+Show Affiliations

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24135335

Citation

Zhang, Yu-Han, et al. "The Relationship Between the Phenotype of Parkinson's Disease and Levodopa-induced Dyskinesia." Neuroscience Letters, vol. 556, 2013, pp. 109-12.
Zhang YH, Tang BS, Song CY, et al. The relationship between the phenotype of Parkinson's disease and levodopa-induced dyskinesia. Neurosci Lett. 2013;556:109-12.
Zhang, Y. H., Tang, B. S., Song, C. Y., Xu, Q., Lou, M. X., Liu, Z. H., Yu, R. H., Yan, X. X., & Guo, J. F. (2013). The relationship between the phenotype of Parkinson's disease and levodopa-induced dyskinesia. Neuroscience Letters, 556, 109-12. https://doi.org/10.1016/j.neulet.2013.10.018
Zhang YH, et al. The Relationship Between the Phenotype of Parkinson's Disease and Levodopa-induced Dyskinesia. Neurosci Lett. 2013 Nov 27;556:109-12. PubMed PMID: 24135335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between the phenotype of Parkinson's disease and levodopa-induced dyskinesia. AU - Zhang,Yu-Han, AU - Tang,Bei-Sha, AU - Song,Chen-Yuan, AU - Xu,Qian, AU - Lou,Ming-Xin, AU - Liu,Zhen-Hua, AU - Yu,Ren-He, AU - Yan,Xin-Xiang, AU - Guo,Ji-Feng, Y1 - 2013/10/14/ PY - 2013/05/12/received PY - 2013/10/01/revised PY - 2013/10/05/accepted PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2014/2/11/medline KW - Clinical phenotype KW - Levodopa-induced dyskinesia KW - Parkinson's disease SP - 109 EP - 12 JF - Neuroscience letters JO - Neurosci Lett VL - 556 N2 - Levodopa has been demonstrated to be an effective medication for Parkinson's disease (PD), but its long-term use is complicated by the subsequent development of dyskinesias. Few studies have distinguished distinct PD subtypes associated with the occurrence of Levodopa-Induced Dyskinesia (LID). Therefore, we performed a retrospective analysis to determine if the specific phenotype of PD and other epidemiological factors are associated with the development of LID. Of 367 PD patients taking levodopa, 101 of them developed LID. Multivariate logistic regression analysis demonstrated that initial tremor-dominant manifestation was associated with a reduced risk of LID, independent of other risk factors, such as age at the onset of PD, the duration and dose of levodopa. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24135335/The_relationship_between_the_phenotype_of_Parkinson's_disease_and_levodopa_induced_dyskinesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(13)00922-1 DB - PRIME DP - Unbound Medicine ER -