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Putative association of GPC5 polymorphism with the risk of inflammatory demyelinating diseases.
J Neurol Sci 2013; 335(1-2):82-8JN

Abstract

Inflammatory demyelinating diseases (IDDs) are severe inflammatory diseases of the central nervous system (CNS) that cause loss of myelin in the nerve sheaths and axonal degeneration. IDDs include multiple sclerosis (MS) and neuromyelitis optica (NMO). MS affects the axons of the brain and spinal cord, while NMO primarily affects the optic nerves and spinal cord. Glypican 5 (GPC5) is known to be one of the susceptible genes for the risk of IDD, especially MS, based on genome-wide association studies (GWASs) and replication studies in Caucasians and African Americans. In the present study, in order to investigate the replicable genetic effects of GPC5 polymorphisms on the risk of IDD in Korean subjects, nine genetic variants were selected and genotyped in 237 normal controls and 178 IDD patients (including 79 MS and 99 NMO). Statistical analysis revealed that rs9523762 was associated with IDD and the association was retained even after correction for multiple testing (OR=1.68, P(corr)=0.03). Marginal association was also observed in rs1411751 (OR=0.54, P=0.02). In a subgroup analysis, rs1411751 was found to be associated with NMO (OR=0.36, P(corr)=0.03), and rs9523762 was marginally associated with both NMO and MS. These results indicate that GPC5 polymorphisms would be useful genetic indicators for IDDs, including NMO and MS.

Authors+Show Affiliations

Department of Life Science, Sogang University, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24135429

Citation

Shin, Joong-Gon, et al. "Putative Association of GPC5 Polymorphism With the Risk of Inflammatory Demyelinating Diseases." Journal of the Neurological Sciences, vol. 335, no. 1-2, 2013, pp. 82-8.
Shin JG, Kim HJ, Park BL, et al. Putative association of GPC5 polymorphism with the risk of inflammatory demyelinating diseases. J Neurol Sci. 2013;335(1-2):82-8.
Shin, J. G., Kim, H. J., Park, B. L., Bae, J. S., Kim, L. H., Cheong, H. S., & Shin, H. D. (2013). Putative association of GPC5 polymorphism with the risk of inflammatory demyelinating diseases. Journal of the Neurological Sciences, 335(1-2), pp. 82-8. doi:10.1016/j.jns.2013.08.031.
Shin JG, et al. Putative Association of GPC5 Polymorphism With the Risk of Inflammatory Demyelinating Diseases. J Neurol Sci. 2013 Dec 15;335(1-2):82-8. PubMed PMID: 24135429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Putative association of GPC5 polymorphism with the risk of inflammatory demyelinating diseases. AU - Shin,Joong-Gon, AU - Kim,Ho Jin, AU - Park,Byung Lae, AU - Bae,Joon Seol, AU - Kim,Lyoung Hyo, AU - Cheong,Hyun Sub, AU - Shin,Hyoung Doo, Y1 - 2013/08/30/ PY - 2013/02/20/received PY - 2013/08/19/revised PY - 2013/08/21/accepted PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2014/7/8/medline KW - GPC5 KW - Haplotype KW - Inflammatory demyelinating diseases KW - Multiple sclerosis KW - Neuromyelitis optica KW - Single-nucleotide polymorphism SP - 82 EP - 8 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 335 IS - 1-2 N2 - Inflammatory demyelinating diseases (IDDs) are severe inflammatory diseases of the central nervous system (CNS) that cause loss of myelin in the nerve sheaths and axonal degeneration. IDDs include multiple sclerosis (MS) and neuromyelitis optica (NMO). MS affects the axons of the brain and spinal cord, while NMO primarily affects the optic nerves and spinal cord. Glypican 5 (GPC5) is known to be one of the susceptible genes for the risk of IDD, especially MS, based on genome-wide association studies (GWASs) and replication studies in Caucasians and African Americans. In the present study, in order to investigate the replicable genetic effects of GPC5 polymorphisms on the risk of IDD in Korean subjects, nine genetic variants were selected and genotyped in 237 normal controls and 178 IDD patients (including 79 MS and 99 NMO). Statistical analysis revealed that rs9523762 was associated with IDD and the association was retained even after correction for multiple testing (OR=1.68, P(corr)=0.03). Marginal association was also observed in rs1411751 (OR=0.54, P=0.02). In a subgroup analysis, rs1411751 was found to be associated with NMO (OR=0.36, P(corr)=0.03), and rs9523762 was marginally associated with both NMO and MS. These results indicate that GPC5 polymorphisms would be useful genetic indicators for IDDs, including NMO and MS. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/24135429/Putative_association_of_GPC5_polymorphism_with_the_risk_of_inflammatory_demyelinating_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(13)02880-3 DB - PRIME DP - Unbound Medicine ER -