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Screening of selected medicinal plants for in vitro antidermatophytic activity.
J Mycol Med. 2013 Dec; 23(4):247-54.JM

Abstract

Different solvent extracts of leaves of Achyranthes aspera, Aegle marmelos, Cleistanthus collinus, Curcuma aromatica and Strychnos nux-vomica were screened against dermatophytes viz., Trichophyton mentagrophytes, T. rubrum, Microsporum gypseum, M. canis and Epidermophyton floccossum var. nigricans. The mean zones of inhibition were between 7.1 and 26.5mm. Minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) were from 7.81 to 500 and from 15.62 to 1000μg/mL respectively. The highest mean zone of inhibition (26.5mm), the lowest MIC value (7.81μg/ml) and the lowest MFC (15.62μg/ml) were observed in ethyl acetate extract of A. aspera against T. rubrum. The standard antifungal drug ketoconazole (10μg/disc) was used as the positive control and mean zones of inhibition were from 23 to 29mm. Further separation of active principle from ethyl acetate extract of A. aspera is under progress.

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Authors+Show Affiliations

Kalaivanan C
Department of Botany, Annamalai University, Annamalainagar, Tamil Nadu, India.
Chandrasekaran M
No affiliation info available
Venkatesalu V
No affiliation info available

MeSH

AcetatesAntifungal AgentsChloroformDisk Diffusion Antimicrobial TestsDrug DiscoveryDrug Evaluation, PreclinicalEpidermophytonHexanesIndiaMethanolMicrobial Sensitivity TestsMicrosporumPlant ExtractsPlant LeavesPlants, MedicinalSolventsTrichophyton

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24135649

Citation

Kalaivanan, C, et al. "Screening of Selected Medicinal Plants for in Vitro Antidermatophytic Activity." Journal De Mycologie Medicale, vol. 23, no. 4, 2013, pp. 247-54.
Kalaivanan C, Chandrasekaran M, Venkatesalu V. Screening of selected medicinal plants for in vitro antidermatophytic activity. J Mycol Med. 2013;23(4):247-54.
Kalaivanan, C., Chandrasekaran, M., & Venkatesalu, V. (2013). Screening of selected medicinal plants for in vitro antidermatophytic activity. Journal De Mycologie Medicale, 23(4), 247-54. https://doi.org/10.1016/j.mycmed.2013.09.004
Kalaivanan C, Chandrasekaran M, Venkatesalu V. Screening of Selected Medicinal Plants for in Vitro Antidermatophytic Activity. J Mycol Med. 2013;23(4):247-54. PubMed PMID: 24135649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of selected medicinal plants for in vitro antidermatophytic activity. AU - Kalaivanan,C, AU - Chandrasekaran,M, AU - Venkatesalu,V, Y1 - 2013/10/14/ PY - 2013/02/16/received PY - 2013/07/31/revised PY - 2013/09/14/accepted PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2015/1/13/medline KW - Achyranthes aspera KW - Activité antidermatophytique KW - Antidermatophytic activity KW - Epidermophyton KW - Microsporum KW - Trichophyton SP - 247 EP - 54 JF - Journal de mycologie medicale JO - J Mycol Med VL - 23 IS - 4 N2 - Different solvent extracts of leaves of Achyranthes aspera, Aegle marmelos, Cleistanthus collinus, Curcuma aromatica and Strychnos nux-vomica were screened against dermatophytes viz., Trichophyton mentagrophytes, T. rubrum, Microsporum gypseum, M. canis and Epidermophyton floccossum var. nigricans. The mean zones of inhibition were between 7.1 and 26.5mm. Minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) were from 7.81 to 500 and from 15.62 to 1000μg/mL respectively. The highest mean zone of inhibition (26.5mm), the lowest MIC value (7.81μg/ml) and the lowest MFC (15.62μg/ml) were observed in ethyl acetate extract of A. aspera against T. rubrum. The standard antifungal drug ketoconazole (10μg/disc) was used as the positive control and mean zones of inhibition were from 23 to 29mm. Further separation of active principle from ethyl acetate extract of A. aspera is under progress. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/24135649/Screening_of_selected_medicinal_plants_for_in_vitro_antidermatophytic_activity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1156-5233(13)00161-3 DB - PRIME DP - Unbound Medicine ER -