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Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes.
Invest Ophthalmol Vis Sci. 2013 Nov 05; 54(12):7309-16.IO

Abstract

PURPOSE

To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects.

METHODS

Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey of Singaporean Chinese aged 40 to 80 years. All subjects underwent standardized systemic and ocular examinations. Nonglaucomatous eyes were defined as eyes with normal, reliable visual field results. Retinal vascular parameters (retinal vascular fractal dimension, tortuosity, and caliber) were measured from retinal photographs by using a computer-assisted program, according to a standardized protocol. Spectral-domain optical coherence tomography (SD-OCT) was used to measure RNFL and macular GC-IPL thicknesses.

RESULTS

A total of 352 nonglaucomatous subjects with gradable retinal photographs and OCT images were included for the final analyses. In multiple regression analyses, after adjusting for age, sex, hypertension, diabetes, axial length, disc area, and OCT signal strength; decreased retinal vascular fractal dimension (β = -1.60, P = 0.002), narrower retinal arteriolar caliber (β = -1.60, P = 0.001), and venular caliber (β = -1.97, P < 0.001) were independently associated with thinner average RNFL thickness. In addition, decreased retinal vascular fractal dimension (β = -0.77, P = 0.017) and decreased retinal venular tortuosity (β = -0.63, P = 0.042) were independently associated with thinner average GC-IPL thickness after adjusting for age, sex, hypertension, diabetes, axial length, and OCT signal strength.

CONCLUSIONS

Rarefaction, vasoconstriction, and straightening of the retinal vasculature are associated with thinner RNFL and GC-IPL thickness. This information may potentially provide further insights on the role of vascular processes in glaucoma development and progression.

Authors+Show Affiliations

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24135760

Citation

Tham, Yih-Chung, et al. "Relationship Between Retinal Vascular Geometry With Retinal Nerve Fiber Layer and Ganglion Cell-inner Plexiform Layer in Nonglaucomatous Eyes." Investigative Ophthalmology & Visual Science, vol. 54, no. 12, 2013, pp. 7309-16.
Tham YC, Cheng CY, Zheng Y, et al. Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes. Invest Ophthalmol Vis Sci. 2013;54(12):7309-16.
Tham, Y. C., Cheng, C. Y., Zheng, Y., Aung, T., Wong, T. Y., & Cheung, C. Y. (2013). Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes. Investigative Ophthalmology & Visual Science, 54(12), 7309-16. https://doi.org/10.1167/iovs.13-12796
Tham YC, et al. Relationship Between Retinal Vascular Geometry With Retinal Nerve Fiber Layer and Ganglion Cell-inner Plexiform Layer in Nonglaucomatous Eyes. Invest Ophthalmol Vis Sci. 2013 Nov 5;54(12):7309-16. PubMed PMID: 24135760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes. AU - Tham,Yih-Chung, AU - Cheng,Ching-Yu, AU - Zheng,Yingfeng, AU - Aung,Tin, AU - Wong,Tien Yin, AU - Cheung,Carol Y, Y1 - 2013/11/05/ PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2013/12/24/medline KW - ganglion cell-inner plexiform layer KW - optical coherence tomography KW - retinal nerve fiber layer KW - retinal vasculature SP - 7309 EP - 16 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 54 IS - 12 N2 - PURPOSE: To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects. METHODS: Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey of Singaporean Chinese aged 40 to 80 years. All subjects underwent standardized systemic and ocular examinations. Nonglaucomatous eyes were defined as eyes with normal, reliable visual field results. Retinal vascular parameters (retinal vascular fractal dimension, tortuosity, and caliber) were measured from retinal photographs by using a computer-assisted program, according to a standardized protocol. Spectral-domain optical coherence tomography (SD-OCT) was used to measure RNFL and macular GC-IPL thicknesses. RESULTS: A total of 352 nonglaucomatous subjects with gradable retinal photographs and OCT images were included for the final analyses. In multiple regression analyses, after adjusting for age, sex, hypertension, diabetes, axial length, disc area, and OCT signal strength; decreased retinal vascular fractal dimension (β = -1.60, P = 0.002), narrower retinal arteriolar caliber (β = -1.60, P = 0.001), and venular caliber (β = -1.97, P < 0.001) were independently associated with thinner average RNFL thickness. In addition, decreased retinal vascular fractal dimension (β = -0.77, P = 0.017) and decreased retinal venular tortuosity (β = -0.63, P = 0.042) were independently associated with thinner average GC-IPL thickness after adjusting for age, sex, hypertension, diabetes, axial length, and OCT signal strength. CONCLUSIONS: Rarefaction, vasoconstriction, and straightening of the retinal vasculature are associated with thinner RNFL and GC-IPL thickness. This information may potentially provide further insights on the role of vascular processes in glaucoma development and progression. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24135760/Relationship_between_retinal_vascular_geometry_with_retinal_nerve_fiber_layer_and_ganglion_cell_inner_plexiform_layer_in_nonglaucomatous_eyes_ DB - PRIME DP - Unbound Medicine ER -