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Separate effects of topical indomethacin on the itch response and on the flare reaction induced by histamine in human skin.
Acta Derm Venereol. 1985; 65(4):340-2.AD

Abstract

The effects of topical indomethacin on histamine responses and histamine release were studied in 15 healthy volunteers. Three hours before testing, the indomethacin solution was applied under occlusion on one arm and the corresponding vehicle on the other. Solutions of histamine and the histamine releasing compound 48/80 were injected intradermally in both arms. Indomethacin treatment inhibited the flare reactions induced by histamine and compound 48/80 to about 50%, whereas no influence was seen on the itch responses. Our results indicate that indomethacin has no effect on the release of histamine, but it selectively suppresses the histamine-induced flare reaction leaving the itch duration unaffected.

Authors

Ståhle M
No affiliation info available
Hägermark O
No affiliation info available

MeSH

Administration, TopicalAdolescentAdultErythemaFuransHistamine AntagonistsHistamine ReleaseHumansIndomethacinMiddle AgedNicotinic AcidsSkin

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2413692

Citation

Ståhle, M, and O Hägermark. "Separate Effects of Topical Indomethacin On the Itch Response and On the Flare Reaction Induced By Histamine in Human Skin." Acta Dermato-venereologica, vol. 65, no. 4, 1985, pp. 340-2.
Ståhle M, Hägermark O. Separate effects of topical indomethacin on the itch response and on the flare reaction induced by histamine in human skin. Acta Derm Venereol. 1985;65(4):340-2.
Ståhle, M., & Hägermark, O. (1985). Separate effects of topical indomethacin on the itch response and on the flare reaction induced by histamine in human skin. Acta Dermato-venereologica, 65(4), 340-2.
Ståhle M, Hägermark O. Separate Effects of Topical Indomethacin On the Itch Response and On the Flare Reaction Induced By Histamine in Human Skin. Acta Derm Venereol. 1985;65(4):340-2. PubMed PMID: 2413692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Separate effects of topical indomethacin on the itch response and on the flare reaction induced by histamine in human skin. AU - Ståhle,M, AU - Hägermark,O, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 340 EP - 2 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 65 IS - 4 N2 - The effects of topical indomethacin on histamine responses and histamine release were studied in 15 healthy volunteers. Three hours before testing, the indomethacin solution was applied under occlusion on one arm and the corresponding vehicle on the other. Solutions of histamine and the histamine releasing compound 48/80 were injected intradermally in both arms. Indomethacin treatment inhibited the flare reactions induced by histamine and compound 48/80 to about 50%, whereas no influence was seen on the itch responses. Our results indicate that indomethacin has no effect on the release of histamine, but it selectively suppresses the histamine-induced flare reaction leaving the itch duration unaffected. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/2413692/Separate_effects_of_topical_indomethacin_on_the_itch_response_and_on_the_flare_reaction_induced_by_histamine_in_human_skin_ DB - PRIME DP - Unbound Medicine ER -