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Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels and their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans.
J Prev Med Public Health. 2013 Sep; 46(5):226-36.JP

Abstract

OBJECTIVES

The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans.

METHODS

Serum levels of TCDD were analyzed in 102 Vietnam veterans. Information on age, body mass index, and smoking status were obtained from a self-reported questionnaire. The perceived exposure was assessed by a 6-item questionnaire. Two proximity-based exposures were constructed by division/brigade level and battalion/company level unit information using the Stellman exposure opportunity index model.

RESULTS

The mean and median of serum TCDD levels was 1.2 parts per trillion (ppt) and 0.9 ppt, respectively. Only 2 Vietnam veterans had elevated levels of TCDD (>10 ppt). The levels of TCDD did not tend to increase with the likelihood of exposure to Agent Orange, as estimated from either proximity-based exposure or perceived self-reported exposure. The serum TCDD levels were not significantly different according to military unit, year of first deployment, duration of deployment, military rank, age, body mass index, and smoking status.

CONCLUSIONS

The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations. The unit of deployment, duration of deployment, year of first deployment, military rank, perceived self-reported exposure, and proximity-based exposure to Agent Orange were not associated with TCDD levels in Korean Vietnam veterans. Age, body mass index and smoking also were not associated with TCDD levels.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, Kwandong University College of Medicine, Gangneung, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24137525

Citation

Yi, Sang-Wook, et al. "Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 46, no. 5, 2013, pp. 226-36.
Yi SW, Ohrr H, Won JU, et al. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels and their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. J Prev Med Public Health. 2013;46(5):226-36.
Yi, S. W., Ohrr, H., Won, J. U., Song, J. S., & Hong, J. S. (2013). Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels and their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 46(5), 226-36. https://doi.org/10.3961/jpmph.2013.46.5.226
Yi SW, et al. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans. J Prev Med Public Health. 2013;46(5):226-36. PubMed PMID: 24137525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels and their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. AU - Yi,Sang-Wook, AU - Ohrr,Heechoul, AU - Won,Jong-Uk, AU - Song,Jae-Seok, AU - Hong,Jae-Seok, Y1 - 2013/09/30/ PY - 2013/06/10/received PY - 2013/08/05/accepted PY - 2013/10/19/entrez PY - 2013/10/19/pubmed PY - 2014/7/2/medline KW - Agent Orange KW - Dioxins KW - Korea KW - Tetrachlorodibenzodioxin KW - Veterans KW - Vietnam War SP - 226 EP - 36 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 46 IS - 5 N2 - OBJECTIVES: The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. METHODS: Serum levels of TCDD were analyzed in 102 Vietnam veterans. Information on age, body mass index, and smoking status were obtained from a self-reported questionnaire. The perceived exposure was assessed by a 6-item questionnaire. Two proximity-based exposures were constructed by division/brigade level and battalion/company level unit information using the Stellman exposure opportunity index model. RESULTS: The mean and median of serum TCDD levels was 1.2 parts per trillion (ppt) and 0.9 ppt, respectively. Only 2 Vietnam veterans had elevated levels of TCDD (>10 ppt). The levels of TCDD did not tend to increase with the likelihood of exposure to Agent Orange, as estimated from either proximity-based exposure or perceived self-reported exposure. The serum TCDD levels were not significantly different according to military unit, year of first deployment, duration of deployment, military rank, age, body mass index, and smoking status. CONCLUSIONS: The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations. The unit of deployment, duration of deployment, year of first deployment, military rank, perceived self-reported exposure, and proximity-based exposure to Agent Orange were not associated with TCDD levels in Korean Vietnam veterans. Age, body mass index and smoking also were not associated with TCDD levels. SN - 2233-4521 UR - https://www.unboundmedicine.com/medline/citation/24137525/Serum_2378_tetrachlorodibenzo_p_dioxin_levels_and_their_association_with_age_body_mass_index_smoking_military_record_based_variables_and_estimated_exposure_to_Agent_Orange_in_Korean_Vietnam_veterans_ L2 - https://dx.doi.org/10.3961/jpmph.2013.46.5.226 DB - PRIME DP - Unbound Medicine ER -