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A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats.
Prostaglandins Leukot Essent Fatty Acids. 2013 Nov-Dec; 89(6):391-401.PL

Abstract

This study investigated the efficacy of the plant-based n-3 fatty acid, α-linolenic acid (ALA), a dietary precursor of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for modulating hepatic steatosis. Rats were fed high fat (55% energy) diets containing high oleic canola oil, canola oil, a canola/flax oil blend (C/F, 3:1), safflower oil, soybean oil, or lard. After 12 weeks, C/F and weight-matched (WM) groups had 20% less liver lipid. Body mass, liver weight, glucose and lipid metabolism, inflammation and molecular markers of fatty acid oxidation, synthesis, desaturation and elongation did not account for this effect. The C/F group had the highest total n-3 and EPA in hepatic phospholipids (PL), as well as one of the highest DHA and lowest arachidonic acid (n-6) concentrations. In conclusion, the C/F diet with the highest content of the plant-based n-3 ALA attenuated hepatic steatosis and altered the hepatic PL fatty acid profile.

Authors+Show Affiliations

Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24140006

Citation

Hanke, Danielle, et al. "A Diet High in Α-linolenic Acid and Monounsaturated Fatty Acids Attenuates Hepatic Steatosis and Alters Hepatic Phospholipid Fatty Acid Profile in Diet-induced Obese Rats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 89, no. 6, 2013, pp. 391-401.
Hanke D, Zahradka P, Mohankumar SK, et al. A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. Prostaglandins Leukot Essent Fatty Acids. 2013;89(6):391-401.
Hanke, D., Zahradka, P., Mohankumar, S. K., Clark, J. L., & Taylor, C. G. (2013). A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 89(6), 391-401. https://doi.org/10.1016/j.plefa.2013.09.009
Hanke D, et al. A Diet High in Α-linolenic Acid and Monounsaturated Fatty Acids Attenuates Hepatic Steatosis and Alters Hepatic Phospholipid Fatty Acid Profile in Diet-induced Obese Rats. Prostaglandins Leukot Essent Fatty Acids. 2013 Nov-Dec;89(6):391-401. PubMed PMID: 24140006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. AU - Hanke,Danielle, AU - Zahradka,Peter, AU - Mohankumar,Suresh K, AU - Clark,Jaime L, AU - Taylor,Carla G, Y1 - 2013/09/21/ PY - 2013/07/16/received PY - 2013/09/12/revised PY - 2013/09/16/accepted PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2014/6/17/medline KW - (ACC1) KW - (ACOX1) KW - (ALA) KW - (ALT) KW - (AST) KW - (DHA) KW - (DIO) KW - (EPA) KW - (HOMA-IR) KW - (MCP-1) KW - (MUFA) KW - (NAFLD) KW - (PL) KW - (PPAR-α) KW - (PUFA) KW - (SFA) KW - (SREBP-1c) KW - (TAG) KW - Diet-induced obese rats KW - Hepatic steatosis KW - MUFA KW - acetyl-CoA carboxylase 1 KW - acetyl-CoA oxidase 1 KW - alanine aminotransferase KW - aspartate aminotransferase KW - diet-induced obese KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - homeostasis model assessment-insulin resistance KW - monocyte chemoattractant protein-1 KW - monounsaturated fatty acids KW - non-alcoholic fatty liver disease KW - n−3 fatty acids KW - peroxisome proliferator activated receptor α KW - phospholipids KW - polyunsaturated fatty acids KW - saturated fatty acids KW - sterol regulatory element-binding protein-1c KW - triacylglycerols KW - α-linolenic acid SP - 391 EP - 401 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 89 IS - 6 N2 - This study investigated the efficacy of the plant-based n-3 fatty acid, α-linolenic acid (ALA), a dietary precursor of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for modulating hepatic steatosis. Rats were fed high fat (55% energy) diets containing high oleic canola oil, canola oil, a canola/flax oil blend (C/F, 3:1), safflower oil, soybean oil, or lard. After 12 weeks, C/F and weight-matched (WM) groups had 20% less liver lipid. Body mass, liver weight, glucose and lipid metabolism, inflammation and molecular markers of fatty acid oxidation, synthesis, desaturation and elongation did not account for this effect. The C/F group had the highest total n-3 and EPA in hepatic phospholipids (PL), as well as one of the highest DHA and lowest arachidonic acid (n-6) concentrations. In conclusion, the C/F diet with the highest content of the plant-based n-3 ALA attenuated hepatic steatosis and altered the hepatic PL fatty acid profile. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/24140006/A_diet_high_in_α_linolenic_acid_and_monounsaturated_fatty_acids_attenuates_hepatic_steatosis_and_alters_hepatic_phospholipid_fatty_acid_profile_in_diet_induced_obese_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(13)00190-7 DB - PRIME DP - Unbound Medicine ER -