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The heart is better protected against myocardial infarction in the fed state compared to the fasted state.
Metabolism. 2014 Jan; 63(1):127-36.M

Abstract

OBJECTIVE

A variety of calorie restriction diets and fasting regimens are popular among overweight people. However, starvation could result in unexpected cardiovascular effects. Therefore, it is necessary to evaluate the short-term effects of diets on cardiovascular function, energy metabolism and potential risk of heart damage in case of myocardial infarction. The objective of the present study was to investigate whether the increased level of glucose oxidation or reduction of fatty acid (FA) load in the fed state provides the basis for protection against myocardial infarction in an experimental rat model of ischemia-reperfusion.

MATERIALS/METHODS

We tested the effects of the availability of energy substrates and their metabolites on the heart functionality and energy metabolism under normoxic and ischemia-reperfusion conditions.

RESULTS

In a fasted state, the heart draws energy exclusively from FAs, whereas in a fed state, higher concentration of circulating insulin ensures a partial switch to glucose oxidation, while the load of FA on heart and mitochondria is reduced. Herein, we demonstrate that ischemic damage in hearts isolated from Wistar rats and diabetic Goto-Kakizaki rats is significantly lower in the fed state compared to the fasted state.

CONCLUSIONS

Present findings indicate that postprandial or fed-state physiology, which is characterised by insulin-activated glucose and lactate utilisation, is protective against myocardial infarction. Energy metabolism pattern in the heart is determined by insulin signalling and the availability of FAs. Overall, our study suggests that even overnight fasting could provoke and aggravate cardiovascular events and high-risk cardiovascular patients should avoid prolonged fasting periods.

Authors+Show Affiliations

Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV-1006, Latvia. Electronic address: ledgars@biomed.lu.lv.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24140100

Citation

Liepinsh, Edgars, et al. "The Heart Is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State." Metabolism: Clinical and Experimental, vol. 63, no. 1, 2014, pp. 127-36.
Liepinsh E, Makrecka M, Kuka J, et al. The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism. 2014;63(1):127-36.
Liepinsh, E., Makrecka, M., Kuka, J., Makarova, E., Vilskersts, R., Cirule, H., Sevostjanovs, E., Grinberga, S., Pugovics, O., & Dambrova, M. (2014). The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism: Clinical and Experimental, 63(1), 127-36. https://doi.org/10.1016/j.metabol.2013.09.014
Liepinsh E, et al. The Heart Is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State. Metabolism. 2014;63(1):127-36. PubMed PMID: 24140100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The heart is better protected against myocardial infarction in the fed state compared to the fasted state. AU - Liepinsh,Edgars, AU - Makrecka,Marina, AU - Kuka,Janis, AU - Makarova,Elina, AU - Vilskersts,Reinis, AU - Cirule,Helena, AU - Sevostjanovs,Eduards, AU - Grinberga,Solveiga, AU - Pugovics,Osvalds, AU - Dambrova,Maija, Y1 - 2013/10/18/ PY - 2013/07/03/received PY - 2013/09/06/revised PY - 2013/09/17/accepted PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2014/2/4/medline KW - AN KW - AR KW - ATP KW - BSA KW - CPT1A, CPT1B KW - ETC KW - FA KW - FATP1 KW - Fasted KW - Fatty acids KW - Fed KW - GIK KW - GK KW - Glucose KW - Glut1, Glut4 KW - Goto–Kakizaki KW - HK2 KW - HR KW - HSL KW - IS KW - Insulin KW - KH KW - Krebs–Henseleit KW - LAD KW - LVDP KW - P-Akt KW - PDHx KW - PDK4 KW - PGC-1α KW - PPAR-α KW - ROS KW - SEM KW - TG KW - UCP1, UCP3 KW - adenosine triphosphate KW - area at risk KW - area of necrosis KW - bovine serum albumin KW - carnitine palmitoyltransferase 1A and 1B KW - electron transfer chain KW - fatty acid KW - fatty acid transport protein 1 KW - glucose transporter 1 and 4 KW - glucose–insulin–potassium KW - heart rate KW - hexokinase 2 KW - hormone-sensitive lipase KW - infarct size KW - left anterior descending coronary artery KW - left ventricular developed pressure KW - peroxisome proliferator-activated receptor alpha KW - peroxisome proliferator-activated receptor-γ coactivator KW - phosphorylated Akt KW - pyruvate dehydrogenase complex, component X KW - pyruvate dehydrogenase lipoamide kinase isozyme 4 KW - qRT-PCR KW - quantitative reverse transcriptase polymerase chain reaction KW - reactive oxygen species KW - standard error of the mean KW - triglycerides KW - uncoupling proteins 1 and 3 SP - 127 EP - 36 JF - Metabolism: clinical and experimental JO - Metabolism VL - 63 IS - 1 N2 - OBJECTIVE: A variety of calorie restriction diets and fasting regimens are popular among overweight people. However, starvation could result in unexpected cardiovascular effects. Therefore, it is necessary to evaluate the short-term effects of diets on cardiovascular function, energy metabolism and potential risk of heart damage in case of myocardial infarction. The objective of the present study was to investigate whether the increased level of glucose oxidation or reduction of fatty acid (FA) load in the fed state provides the basis for protection against myocardial infarction in an experimental rat model of ischemia-reperfusion. MATERIALS/METHODS: We tested the effects of the availability of energy substrates and their metabolites on the heart functionality and energy metabolism under normoxic and ischemia-reperfusion conditions. RESULTS: In a fasted state, the heart draws energy exclusively from FAs, whereas in a fed state, higher concentration of circulating insulin ensures a partial switch to glucose oxidation, while the load of FA on heart and mitochondria is reduced. Herein, we demonstrate that ischemic damage in hearts isolated from Wistar rats and diabetic Goto-Kakizaki rats is significantly lower in the fed state compared to the fasted state. CONCLUSIONS: Present findings indicate that postprandial or fed-state physiology, which is characterised by insulin-activated glucose and lactate utilisation, is protective against myocardial infarction. Energy metabolism pattern in the heart is determined by insulin signalling and the availability of FAs. Overall, our study suggests that even overnight fasting could provoke and aggravate cardiovascular events and high-risk cardiovascular patients should avoid prolonged fasting periods. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/24140100/The_heart_is_better_protected_against_myocardial_infarction_in_the_fed_state_compared_to_the_fasted_state_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(13)00298-9 DB - PRIME DP - Unbound Medicine ER -