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FTY720 protects neuronal cells from damage induced by human prion protein by inactivating the JNK pathway.
Int J Mol Med. 2013 Dec; 32(6):1387-93.IJ

Abstract

Prion diseases affect the central nervous system (CNS) in humans and animals, and are associated with the conversion of the cellular prion protein (PrPC) to the misfolded isoform (PrPSc). FTY720, an immune modulator and synthetic analogue of sphingosine-1-phosphate (S1P), activates S1P receptors and has been shown to be effective in experimental models of transplantation and autoimmunity, including multiple sclerosis. Whereas the immune modulatory functions of FTY720 have been extensively investigated, the other functions of FTY720 are not yet well understood. In this study, we investigated the effects of FTY720 phosphate (FTY720-p) on prion protein-mediated neuronal cell death, as well as its effects on intracellular apoptotic pathways. Treatment with FTY720-p protected neuronal cells from synthetic human prion protein peptide [PrP (106‑126)]-mediated damage and prevented mitochondrial dysfunction by inhibiting the activation of c-jun N-terminal kinase. Moreover, FTY720-p prevented the PrP (106‑126)-induced reduction in mitochondrial potential, the translocation of Bax to the mitochondria and the release of cytochrome c. To the best of our knowledge, this study is the first to demonstrate the effects of FTY720 on prion protein-mediated neurotoxicity and to suggest that FTY720 has therapeutic potential in prion diseases.

Authors+Show Affiliations

Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24142108

Citation

Moon, Myung-Hee, et al. "FTY720 Protects Neuronal Cells From Damage Induced By Human Prion Protein By Inactivating the JNK Pathway." International Journal of Molecular Medicine, vol. 32, no. 6, 2013, pp. 1387-93.
Moon MH, Jeong JK, Lee YJ, et al. FTY720 protects neuronal cells from damage induced by human prion protein by inactivating the JNK pathway. Int J Mol Med. 2013;32(6):1387-93.
Moon, M. H., Jeong, J. K., Lee, Y. J., & Park, S. Y. (2013). FTY720 protects neuronal cells from damage induced by human prion protein by inactivating the JNK pathway. International Journal of Molecular Medicine, 32(6), 1387-93. https://doi.org/10.3892/ijmm.2013.1528
Moon MH, et al. FTY720 Protects Neuronal Cells From Damage Induced By Human Prion Protein By Inactivating the JNK Pathway. Int J Mol Med. 2013;32(6):1387-93. PubMed PMID: 24142108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FTY720 protects neuronal cells from damage induced by human prion protein by inactivating the JNK pathway. AU - Moon,Myung-Hee, AU - Jeong,Jae-Kyo, AU - Lee,You-Jin, AU - Park,Sang-Youel, Y1 - 2013/10/16/ PY - 2013/07/20/received PY - 2013/10/08/accepted PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2014/5/28/medline SP - 1387 EP - 93 JF - International journal of molecular medicine JO - Int. J. Mol. Med. VL - 32 IS - 6 N2 - Prion diseases affect the central nervous system (CNS) in humans and animals, and are associated with the conversion of the cellular prion protein (PrPC) to the misfolded isoform (PrPSc). FTY720, an immune modulator and synthetic analogue of sphingosine-1-phosphate (S1P), activates S1P receptors and has been shown to be effective in experimental models of transplantation and autoimmunity, including multiple sclerosis. Whereas the immune modulatory functions of FTY720 have been extensively investigated, the other functions of FTY720 are not yet well understood. In this study, we investigated the effects of FTY720 phosphate (FTY720-p) on prion protein-mediated neuronal cell death, as well as its effects on intracellular apoptotic pathways. Treatment with FTY720-p protected neuronal cells from synthetic human prion protein peptide [PrP (106‑126)]-mediated damage and prevented mitochondrial dysfunction by inhibiting the activation of c-jun N-terminal kinase. Moreover, FTY720-p prevented the PrP (106‑126)-induced reduction in mitochondrial potential, the translocation of Bax to the mitochondria and the release of cytochrome c. To the best of our knowledge, this study is the first to demonstrate the effects of FTY720 on prion protein-mediated neurotoxicity and to suggest that FTY720 has therapeutic potential in prion diseases. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/24142108/FTY720_protects_neuronal_cells_from_damage_induced_by_human_prion_protein_by_inactivating_the_JNK_pathway_ L2 - http://www.spandidos-publications.com/ijmm/32/6/1387 DB - PRIME DP - Unbound Medicine ER -