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Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia.
Environ Toxicol Chem. 2014 Feb; 33(2):394-403.ET

Abstract

While it is increasingly being recognized that biotic ligand models (BLMs) are valuable in the risk assessment of metals in aquatic systems, the development of chronic BLMs has been less advanced for lead than for other metals. The authors investigated the univariate effects of Ca and pH on the chronic reproductive toxicity of Pb to Ceriodaphnia dubia at 4 levels. Calcium influenced chronic Pb toxicity to C. dubia only to a relatively small extent, whereas a high pH (8.2) provided strong protection against Pb toxicity (compared with lower pH levels). Based on this data set, a chronic Pb BLM for C. dubia was developed. The effect of pH was modeled as a single biotic ligand site competition by H(+) with a log stability constant for binding of H(+) to the biotic ligand (K(HBL)) of 7.6, while no other competitive constants were needed. The developed BLM was shown, in an independent validation with 3 other data sets, to be capable of predicting chronic Pb toxicity to different clones of C. dubia by an error of less than a factor of 2 in most synthetic and natural waters considered. The results add to the growing evidence that BLM-based risk assessment or water-quality criteria for Pb are likely to be more appropriate relative to hardness-based assessments or criteria.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Nys C
Faculty of Bioscience Engineering, Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Ghent, Belgium.
Janssen CR
No affiliation info available
Mager EM
No affiliation info available
Esbaugh AJ
No affiliation info available
Brix KV
No affiliation info available
Grosell M
No affiliation info available
Stubblefield WA
No affiliation info available
Holtze K
No affiliation info available
De Schamphelaere KA
No affiliation info available

MeSH

AnimalsCalciumCladoceraFemaleHydrogen-Ion ConcentrationLeadLigandsMaleModels, TheoreticalReproductionWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24142571

Citation

Nys, Charlotte, et al. "Development and Validation of a Biotic Ligand Model for Predicting Chronic Toxicity of Lead to Ceriodaphnia Dubia." Environmental Toxicology and Chemistry, vol. 33, no. 2, 2014, pp. 394-403.
Nys C, Janssen CR, Mager EM, et al. Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia. Environ Toxicol Chem. 2014;33(2):394-403.
Nys, C., Janssen, C. R., Mager, E. M., Esbaugh, A. J., Brix, K. V., Grosell, M., Stubblefield, W. A., Holtze, K., & De Schamphelaere, K. A. (2014). Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia. Environmental Toxicology and Chemistry, 33(2), 394-403. https://doi.org/10.1002/etc.2433
Nys C, et al. Development and Validation of a Biotic Ligand Model for Predicting Chronic Toxicity of Lead to Ceriodaphnia Dubia. Environ Toxicol Chem. 2014;33(2):394-403. PubMed PMID: 24142571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia. AU - Nys,Charlotte, AU - Janssen,Colin R, AU - Mager,Edward M, AU - Esbaugh,Andrew J, AU - Brix,Kevin V, AU - Grosell,Martin, AU - Stubblefield,William A, AU - Holtze,Keith, AU - De Schamphelaere,Karel A C, Y1 - 2013/12/20/ PY - 2013/05/11/received PY - 2013/07/09/revised PY - 2013/10/11/accepted PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2014/5/23/medline KW - Biotic ligand model KW - Daphnia KW - Metal bioavailability KW - Risk assessment KW - Water-quality criteria SP - 394 EP - 403 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 33 IS - 2 N2 - While it is increasingly being recognized that biotic ligand models (BLMs) are valuable in the risk assessment of metals in aquatic systems, the development of chronic BLMs has been less advanced for lead than for other metals. The authors investigated the univariate effects of Ca and pH on the chronic reproductive toxicity of Pb to Ceriodaphnia dubia at 4 levels. Calcium influenced chronic Pb toxicity to C. dubia only to a relatively small extent, whereas a high pH (8.2) provided strong protection against Pb toxicity (compared with lower pH levels). Based on this data set, a chronic Pb BLM for C. dubia was developed. The effect of pH was modeled as a single biotic ligand site competition by H(+) with a log stability constant for binding of H(+) to the biotic ligand (K(HBL)) of 7.6, while no other competitive constants were needed. The developed BLM was shown, in an independent validation with 3 other data sets, to be capable of predicting chronic Pb toxicity to different clones of C. dubia by an error of less than a factor of 2 in most synthetic and natural waters considered. The results add to the growing evidence that BLM-based risk assessment or water-quality criteria for Pb are likely to be more appropriate relative to hardness-based assessments or criteria. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/24142571/Development_and_validation_of_a_biotic_ligand_model_for_predicting_chronic_toxicity_of_lead_to_Ceriodaphnia_dubia_ L2 - https://doi.org/10.1002/etc.2433 DB - PRIME DP - Unbound Medicine ER -