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Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions.
Cardiol J. 2014; 21(3):245-51.CJ

Abstract

BACKGROUND

The aim of the present study was to assess the relation between metabolic syndrome (MS) and coronary artery disease (CAD) complexity, assessed by Syntax score (SS), and severity in non-diabetic patients with stable CAD who underwent coronary angiography, and to evaluate whether the MS defined by different definitions, including International Diabetes Federation (IDF) and American Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) guidelines, similarly correlated with SS.

METHODS

The present study is cross sectional and observational with prospective inclusion of 248 consecutive patients (157 male) who underwent coronary angiography due to stable CAD.

RESULTS

The prevalence of MS was 54.4% according to IDF definition and 50.4% according to AHA/NHLBI definition. MS score according to IDF definitions (r = 0.446, p < 0.001), MS score according to AHA/NHLBI definitions (r = 0.341, p < 0.001) were moderately correlated with SS. In Fisher r to z transformation test the correlations of the presence of MS according to IDF and AHA/NHLBI definitions with SS were not statistically significant (p = 0.168, z = -1.38). The systolic blood pressure (p < 0.001, B = 0.354, 95% CI = -0.308 to 0.228), diastolic blood pressure (p = 0.006, B = -0.194, 95% CI = -0.333 to -0.056), age (p = 0.014, B = 0.147, 95% CI = 0.029 to 0.264), left ventricular ejection fraction (p = 0.031, B = -0.150, 95% CI= -0.286 to -0.014), waist/hip circumference (p < 0.001, B = 45.713, 95% CI = 23.235 to 68.1919) and log10 high density lipoprotein (p < 0.001, B = -22.209, 95% CI = -33.298 to-11.119) were the independent predictors of SS in linear regression analysis.

CONCLUSIONS

MS is associated with the presence and complexity of CAD. Besides the presence of discrepancy in the limits of waist circumference, both IDF and AHA/NHLBI criteria were similarly correlated with CAD complexity.

Authors+Show Affiliations

Department of Cardiology, Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey. ahmetaykan@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

24142676

Citation

Aykan, Ahmet Çağrı, et al. "Is Metabolic Syndrome Related With Coronary Artery Disease Severity and Complexity: an Observational Study About IDF and AHA/NHLBI Metabolic Syndrome Definitions." Cardiology Journal, vol. 21, no. 3, 2014, pp. 245-51.
Aykan AÇ, Gül İ, Kalaycıoğlu E, et al. Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions. Cardiol J. 2014;21(3):245-51.
Aykan, A. Ç., Gül, İ., Kalaycıoğlu, E., Gökdeniz, T., Hatem, E., Menteşe, Ü., Yıldız, B. Ş., & Yıldız, M. (2014). Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions. Cardiology Journal, 21(3), 245-51. https://doi.org/10.5603/CJ.a2013.0126
Aykan AÇ, et al. Is Metabolic Syndrome Related With Coronary Artery Disease Severity and Complexity: an Observational Study About IDF and AHA/NHLBI Metabolic Syndrome Definitions. Cardiol J. 2014;21(3):245-51. PubMed PMID: 24142676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions. AU - Aykan,Ahmet Çağrı, AU - Gül,İlker, AU - Kalaycıoğlu,Ezgi, AU - Gökdeniz,Tayyar, AU - Hatem,Engin, AU - Menteşe,Ümit, AU - Yıldız,Banu Şahin, AU - Yıldız,Mustafa, Y1 - 2013/10/21/ PY - 2013/05/11/received PY - 2013/08/27/accepted PY - 2013/07/30/revised PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2016/1/15/medline SP - 245 EP - 51 JF - Cardiology journal JO - Cardiol J VL - 21 IS - 3 N2 - BACKGROUND: The aim of the present study was to assess the relation between metabolic syndrome (MS) and coronary artery disease (CAD) complexity, assessed by Syntax score (SS), and severity in non-diabetic patients with stable CAD who underwent coronary angiography, and to evaluate whether the MS defined by different definitions, including International Diabetes Federation (IDF) and American Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) guidelines, similarly correlated with SS. METHODS: The present study is cross sectional and observational with prospective inclusion of 248 consecutive patients (157 male) who underwent coronary angiography due to stable CAD. RESULTS: The prevalence of MS was 54.4% according to IDF definition and 50.4% according to AHA/NHLBI definition. MS score according to IDF definitions (r = 0.446, p < 0.001), MS score according to AHA/NHLBI definitions (r = 0.341, p < 0.001) were moderately correlated with SS. In Fisher r to z transformation test the correlations of the presence of MS according to IDF and AHA/NHLBI definitions with SS were not statistically significant (p = 0.168, z = -1.38). The systolic blood pressure (p < 0.001, B = 0.354, 95% CI = -0.308 to 0.228), diastolic blood pressure (p = 0.006, B = -0.194, 95% CI = -0.333 to -0.056), age (p = 0.014, B = 0.147, 95% CI = 0.029 to 0.264), left ventricular ejection fraction (p = 0.031, B = -0.150, 95% CI= -0.286 to -0.014), waist/hip circumference (p < 0.001, B = 45.713, 95% CI = 23.235 to 68.1919) and log10 high density lipoprotein (p < 0.001, B = -22.209, 95% CI = -33.298 to-11.119) were the independent predictors of SS in linear regression analysis. CONCLUSIONS: MS is associated with the presence and complexity of CAD. Besides the presence of discrepancy in the limits of waist circumference, both IDF and AHA/NHLBI criteria were similarly correlated with CAD complexity. SN - 1897-5593 UR - https://www.unboundmedicine.com/medline/citation/24142676/Is_metabolic_syndrome_related_with_coronary_artery_disease_severity_and_complexity:_An_observational_study_about_IDF_and_AHA/NHLBI_metabolic_syndrome_definitions_ L2 - http://czasopisma.viamedica.pl/cj/article/view/34267 DB - PRIME DP - Unbound Medicine ER -