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Head injuries and Parkinson's disease in a case-control study.
Occup Environ Med. 2013 Dec; 70(12):839-44.OE

Abstract

BACKGROUND

Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms.

METHODS

We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history.

RESULTS

Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant.

CONCLUSIONS

This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.

Authors+Show Affiliations

School of Occupational and Public Health, Ryerson University, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24142978

Citation

Harris, M Anne, et al. "Head Injuries and Parkinson's Disease in a Case-control Study." Occupational and Environmental Medicine, vol. 70, no. 12, 2013, pp. 839-44.
Harris MA, Shen H, Marion SA, et al. Head injuries and Parkinson's disease in a case-control study. Occup Environ Med. 2013;70(12):839-44.
Harris, M. A., Shen, H., Marion, S. A., Tsui, J. K., & Teschke, K. (2013). Head injuries and Parkinson's disease in a case-control study. Occupational and Environmental Medicine, 70(12), 839-44. https://doi.org/10.1136/oemed-2013-101444
Harris MA, et al. Head Injuries and Parkinson's Disease in a Case-control Study. Occup Environ Med. 2013;70(12):839-44. PubMed PMID: 24142978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head injuries and Parkinson's disease in a case-control study. AU - Harris,M Anne, AU - Shen,Hui, AU - Marion,Stephen A, AU - Tsui,Joseph K C, AU - Teschke,Kay, Y1 - 2013/09/18/ PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2014/1/1/medline SP - 839 EP - 44 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 70 IS - 12 N2 - BACKGROUND: Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. METHODS: We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. RESULTS: Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. CONCLUSIONS: This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/24142978/Head_injuries_and_Parkinson's_disease_in_a_case_control_study_ L2 - https://oem.bmj.com/lookup/pmidlookup?view=long&pmid=24142978 DB - PRIME DP - Unbound Medicine ER -