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Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice.

Abstract

OBJECTIVE

Consumption of green-leafy vegetables is being advocated beneficial for type 2 diabetes mellitus individuals possibly because they are cost effective source of potent biological antioxidants. This research analyzed various phytochemicals, free radicals scavenging antioxidant potentials and starch digesting enzymes inhibitory activities in fresh juice of nine green-leafy vegetables. Furthermore, this study also investigated influence of these vegetables juice on starch and glucose induced postprandial glycemic load.

MATERIALS AND METHODS

Phytochemical constituents, in vitro free radicals scavenging antioxidant and enzymes inhibitory activities were evaluated applying various reported methods. Post-prandial glycemic excursion was induced in rats pretreated with vegetables juice by oral administration of starch and glucose.

RESULTS

All the leafy vegetables juice displayed potent free radicals scavenging activities. Juice of amaranthus, rumex, palak and raphanus displayed potential anti-oxidative property by reducing H2O2 induced hemolysis in rats red blood cells RBCs. Ajwain and rumex juice showed pancreatic α-amylase inhibitory activity. Alternanthera, ajwain, methi, amaranthus and sowa leaves juice displayed intestinal α-glucosidase inhibitory activity. Juice of raphanus, ajwain and sowa significantly mitigated starch-induced postprandial glycemic load. Amaranthus leaves juice potently mitigated glucose-induced postprandial glycemic load and also reduced hemoglobin glycation induced by glucose in vitro.

CONCLUSIONS

This investigation finds that juice of leafy vegetables is potent source of biological antioxidants. In addition, juice of raphanus, ajwain and sowa leaves possess capacity to mitigate starch induced postprandial glycemic burden and amaranthus leaves' juice can reduce glucose induced postprandial glycemic excursion.

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  • Authors+Show Affiliations

    ,

    Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.

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    Source

    Pharmacognosy magazine 9:Suppl 1 2013 Oct pg S66-73

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24143048

    Citation

    Tiwari, Ashok Kumar, et al. "Mitigation of Starch and Glucose-induced Postprandial Glycemic Excursion in Rats By Antioxidant-rich Green-leafy Vegetables' Juice." Pharmacognosy Magazine, vol. 9, no. Suppl 1, 2013, pp. S66-73.
    Tiwari AK, Jyothi AL, Tejeswini VB, et al. Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice. Pharmacogn Mag. 2013;9(Suppl 1):S66-73.
    Tiwari, A. K., Jyothi, A. L., Tejeswini, V. B., Madhusudana, K., Kumar, D. A., Zehra, A., & Agawane, S. B. (2013). Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice. Pharmacognosy Magazine, 9(Suppl 1), pp. S66-73. doi:10.4103/0973-1296.117872.
    Tiwari AK, et al. Mitigation of Starch and Glucose-induced Postprandial Glycemic Excursion in Rats By Antioxidant-rich Green-leafy Vegetables' Juice. Pharmacogn Mag. 2013;9(Suppl 1):S66-73. PubMed PMID: 24143048.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mitigation of starch and glucose-induced postprandial glycemic excursion in rats by antioxidant-rich green-leafy vegetables' juice. AU - Tiwari,Ashok Kumar, AU - Jyothi,Atmakuri Lakshmana, AU - Tejeswini,Vasantharao Brahma, AU - Madhusudana,Kuncha, AU - Kumar,Domati Anand, AU - Zehra,Amtul, AU - Agawane,Sachin Bharat, PY - 2012/12/25/received PY - 2013/01/31/revised PY - 2013/09/07/accepted PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2013/10/22/medline KW - Antioxidants KW - enzyme inhibition KW - green-leafy vegetables juice KW - oxidative stress KW - postprandial hyperglycemia SP - S66 EP - 73 JF - Pharmacognosy magazine JO - Pharmacogn Mag VL - 9 IS - Suppl 1 N2 - OBJECTIVE: Consumption of green-leafy vegetables is being advocated beneficial for type 2 diabetes mellitus individuals possibly because they are cost effective source of potent biological antioxidants. This research analyzed various phytochemicals, free radicals scavenging antioxidant potentials and starch digesting enzymes inhibitory activities in fresh juice of nine green-leafy vegetables. Furthermore, this study also investigated influence of these vegetables juice on starch and glucose induced postprandial glycemic load. MATERIALS AND METHODS: Phytochemical constituents, in vitro free radicals scavenging antioxidant and enzymes inhibitory activities were evaluated applying various reported methods. Post-prandial glycemic excursion was induced in rats pretreated with vegetables juice by oral administration of starch and glucose. RESULTS: All the leafy vegetables juice displayed potent free radicals scavenging activities. Juice of amaranthus, rumex, palak and raphanus displayed potential anti-oxidative property by reducing H2O2 induced hemolysis in rats red blood cells RBCs. Ajwain and rumex juice showed pancreatic α-amylase inhibitory activity. Alternanthera, ajwain, methi, amaranthus and sowa leaves juice displayed intestinal α-glucosidase inhibitory activity. Juice of raphanus, ajwain and sowa significantly mitigated starch-induced postprandial glycemic load. Amaranthus leaves juice potently mitigated glucose-induced postprandial glycemic load and also reduced hemoglobin glycation induced by glucose in vitro. CONCLUSIONS: This investigation finds that juice of leafy vegetables is potent source of biological antioxidants. In addition, juice of raphanus, ajwain and sowa leaves possess capacity to mitigate starch induced postprandial glycemic burden and amaranthus leaves' juice can reduce glucose induced postprandial glycemic excursion. SN - 0973-1296 UR - https://www.unboundmedicine.com/medline/citation/24143048/Mitigation_of_starch_and_glucose_induced_postprandial_glycemic_excursion_in_rats_by_antioxidant_rich_green_leafy_vegetables'_juice_ L2 - http://www.phcog.com/article.asp?issn=0973-1296;year=2013;volume=9;issue=36;spage=66;epage=73;aulast=Tiwari DB - PRIME DP - Unbound Medicine ER -