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Is the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation useful for glomerular filtration rate estimation in the elderly?
Clin Interv Aging. 2013; 8:1387-91.CI

Abstract

BACKGROUND

We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation in a cohort of elderly Chinese participants.

MATERIALS AND METHODS

Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) renal dynamic imaging method, and was calibrated equally to the dual plasma sample (99m)Tc-DTPA-GFR. Performance of the CKD-EPI creatinine-cystatin C equation was compared with the Cockcroft-Gault equation, the re-expressed 4-variable Modification of Diet in Renal Disease (MDRD) equation, and the CKD-EPI creatinine equation.

RESULTS

Although the bias of the CKD-EPI creatinine-cystatin C equation was greater than with the other equations (median difference, 5.7 mL/minute/1.73 m(2) versus a range from 0.4-2.5 mL/minute/1.73 m(2); P<0.001 for all), the precision was improved with the CKD-EPI creatinine-cystatin C equation (interquartile range for the difference, 19.5 mL/minute/1.73 m(2) versus a range from 23.0-23.6 mL/minute/1.73 m(2); P<0.001 for all comparisons), leading to slight improvement in accuracy (median absolute difference, 10.5 mL/minute/1.73 m(2) versus 12.2 and 11.4 mL/minute/1.73 m(2) for the Cockcroft-Gault equation and the re-expressed 4-variable MDRD equation, P=0.04 for both; 11.6 mL/minute/1.73 m(2) for the CKD-EPI creatinine equation, P=0.11), as the optimal scores of performance (6.0 versus a range from 1.0-2.0 for the other equations). Higher GFR category and diabetes were independent factors that negatively correlated with the accuracy of the CKD-EPI creatinine-cystatin C equation (β=-0.184 and -0.113, P<0.001 and P=0.02, respectively).

CONCLUSION

Compared with the creatinine-based equations, the CKD-EPI creatinine-cystatin C equation is more suitable for the elderly Chinese population. However, the cost-effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China ; College of Biology Engineering, South China University of Technology, Guangzhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24143084

Citation

Liu, Xun, et al. "Is the Chronic Kidney Disease Epidemiology Collaboration Creatinine-cystatin C Equation Useful for Glomerular Filtration Rate Estimation in the Elderly?" Clinical Interventions in Aging, vol. 8, 2013, pp. 1387-91.
Liu X, Ma H, Huang H, et al. Is the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation useful for glomerular filtration rate estimation in the elderly? Clin Interv Aging. 2013;8:1387-91.
Liu, X., Ma, H., Huang, H., Wang, C., Tang, H., Li, M., Wang, Y., & Lou, T. (2013). Is the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation useful for glomerular filtration rate estimation in the elderly? Clinical Interventions in Aging, 8, 1387-91. https://doi.org/10.2147/CIA.S52774
Liu X, et al. Is the Chronic Kidney Disease Epidemiology Collaboration Creatinine-cystatin C Equation Useful for Glomerular Filtration Rate Estimation in the Elderly. Clin Interv Aging. 2013;8:1387-91. PubMed PMID: 24143084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation useful for glomerular filtration rate estimation in the elderly? AU - Liu,Xun, AU - Ma,Huijuan, AU - Huang,Hui, AU - Wang,Cheng, AU - Tang,Hua, AU - Li,Ming, AU - Wang,Yanni, AU - Lou,Tanqi, Y1 - 2013/10/11/ PY - 2013/10/22/entrez PY - 2013/10/22/pubmed PY - 2014/3/22/medline KW - cystatin C KW - elderly KW - equation KW - glomerular filtration rate KW - serum creatinine SP - 1387 EP - 91 JF - Clinical interventions in aging JO - Clin Interv Aging VL - 8 N2 - BACKGROUND: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation in a cohort of elderly Chinese participants. MATERIALS AND METHODS: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) renal dynamic imaging method, and was calibrated equally to the dual plasma sample (99m)Tc-DTPA-GFR. Performance of the CKD-EPI creatinine-cystatin C equation was compared with the Cockcroft-Gault equation, the re-expressed 4-variable Modification of Diet in Renal Disease (MDRD) equation, and the CKD-EPI creatinine equation. RESULTS: Although the bias of the CKD-EPI creatinine-cystatin C equation was greater than with the other equations (median difference, 5.7 mL/minute/1.73 m(2) versus a range from 0.4-2.5 mL/minute/1.73 m(2); P<0.001 for all), the precision was improved with the CKD-EPI creatinine-cystatin C equation (interquartile range for the difference, 19.5 mL/minute/1.73 m(2) versus a range from 23.0-23.6 mL/minute/1.73 m(2); P<0.001 for all comparisons), leading to slight improvement in accuracy (median absolute difference, 10.5 mL/minute/1.73 m(2) versus 12.2 and 11.4 mL/minute/1.73 m(2) for the Cockcroft-Gault equation and the re-expressed 4-variable MDRD equation, P=0.04 for both; 11.6 mL/minute/1.73 m(2) for the CKD-EPI creatinine equation, P=0.11), as the optimal scores of performance (6.0 versus a range from 1.0-2.0 for the other equations). Higher GFR category and diabetes were independent factors that negatively correlated with the accuracy of the CKD-EPI creatinine-cystatin C equation (β=-0.184 and -0.113, P<0.001 and P=0.02, respectively). CONCLUSION: Compared with the creatinine-based equations, the CKD-EPI creatinine-cystatin C equation is more suitable for the elderly Chinese population. However, the cost-effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered. SN - 1178-1998 UR - https://www.unboundmedicine.com/medline/citation/24143084/Is_the_Chronic_Kidney_Disease_Epidemiology_Collaboration_creatinine_cystatin_C_equation_useful_for_glomerular_filtration_rate_estimation_in_the_elderly L2 - https://dx.doi.org/10.2147/CIA.S52774 DB - PRIME DP - Unbound Medicine ER -