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Impacts of select organic ligands on the colloidal stability, dissolution dynamics, and toxicity of silver nanoparticles.
Environ Sci Technol. 2013 Nov 19; 47(22):12877-85.ES

Abstract

Key understanding of potential transformations that may occur on silver nanoparticle (AgNP) surface upon interaction with naturally ubiquitous organic ligands (e.g., -SH (thoil), humic acid, or -COO (carboxylate)) is limited. Herein we investigated how dissolved organic carbon (DOC), -SH (in cysteine, a well-known Ag(+) chelating agent), and -COO (in trolox, a well-known antioxidant) could alter the colloidal stability, dissolution rate, and toxicity of citrate-functionalized AgNPs (citrate-AgNPs) against a keystone crustacean Daphnia magna. Cysteine, DOC, or trolox amendment of citrate-AgNPs differentially modified particle size, surface properties (charge, plasmonic spectra), and ion release dynamics, thereby attenuating (with cysteine or trolox) or promoting (with DOC) AgNP toxicity. Except with DOC amendment, the combined toxicity of AgNPs and released Ag under cysteine or trolox amendment was lower than of AgNO3 alone. The results of this study show that citrate-AgNP toxicity can be associated with oxidative stress, ion release, and the organism biology. Our evidence suggests that specific organic ligands available in the receiving waters can differentially surface modify AgNPs and alter their environmental persistence (changing dissolution dynamics) and subsequently the toxicity; hence, we caveat to generalize that surface modified nanoparticles upon environmental release may not be toxic to receptor organisms.

Authors+Show Affiliations

Department of Environmental Health, College of Public Health, East Tennessee State University , Johnson City, Tennessee 37614-1700, United States.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24144348

Citation

Pokhrel, Lok R., et al. "Impacts of Select Organic Ligands On the Colloidal Stability, Dissolution Dynamics, and Toxicity of Silver Nanoparticles." Environmental Science & Technology, vol. 47, no. 22, 2013, pp. 12877-85.
Pokhrel LR, Dubey B, Scheuerman PR. Impacts of select organic ligands on the colloidal stability, dissolution dynamics, and toxicity of silver nanoparticles. Environ Sci Technol. 2013;47(22):12877-85.
Pokhrel, L. R., Dubey, B., & Scheuerman, P. R. (2013). Impacts of select organic ligands on the colloidal stability, dissolution dynamics, and toxicity of silver nanoparticles. Environmental Science & Technology, 47(22), 12877-85. https://doi.org/10.1021/es403462j
Pokhrel LR, Dubey B, Scheuerman PR. Impacts of Select Organic Ligands On the Colloidal Stability, Dissolution Dynamics, and Toxicity of Silver Nanoparticles. Environ Sci Technol. 2013 Nov 19;47(22):12877-85. PubMed PMID: 24144348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impacts of select organic ligands on the colloidal stability, dissolution dynamics, and toxicity of silver nanoparticles. AU - Pokhrel,Lok R, AU - Dubey,Brajesh, AU - Scheuerman,Phillip R, Y1 - 2013/11/07/ PY - 2013/10/23/entrez PY - 2013/10/23/pubmed PY - 2014/12/15/medline SP - 12877 EP - 85 JF - Environmental science & technology JO - Environ Sci Technol VL - 47 IS - 22 N2 - Key understanding of potential transformations that may occur on silver nanoparticle (AgNP) surface upon interaction with naturally ubiquitous organic ligands (e.g., -SH (thoil), humic acid, or -COO (carboxylate)) is limited. Herein we investigated how dissolved organic carbon (DOC), -SH (in cysteine, a well-known Ag(+) chelating agent), and -COO (in trolox, a well-known antioxidant) could alter the colloidal stability, dissolution rate, and toxicity of citrate-functionalized AgNPs (citrate-AgNPs) against a keystone crustacean Daphnia magna. Cysteine, DOC, or trolox amendment of citrate-AgNPs differentially modified particle size, surface properties (charge, plasmonic spectra), and ion release dynamics, thereby attenuating (with cysteine or trolox) or promoting (with DOC) AgNP toxicity. Except with DOC amendment, the combined toxicity of AgNPs and released Ag under cysteine or trolox amendment was lower than of AgNO3 alone. The results of this study show that citrate-AgNP toxicity can be associated with oxidative stress, ion release, and the organism biology. Our evidence suggests that specific organic ligands available in the receiving waters can differentially surface modify AgNPs and alter their environmental persistence (changing dissolution dynamics) and subsequently the toxicity; hence, we caveat to generalize that surface modified nanoparticles upon environmental release may not be toxic to receptor organisms. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/24144348/Impacts_of_select_organic_ligands_on_the_colloidal_stability_dissolution_dynamics_and_toxicity_of_silver_nanoparticles_ L2 - https://doi.org/10.1021/es403462j DB - PRIME DP - Unbound Medicine ER -