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Effect of ω-conotoxin MVIIA and Phα1β on paclitaxel-induced acute and chronic pain.
Pharmacol Biochem Behav. 2013 Dec; 114-115:16-22.PB

Abstract

The treatment with the chemotherapeutic agent paclitaxel produces a painful peripheral neuropathy, and is associated with an acute pain syndrome in a clinically significant number of patients. However, no standard therapy has been established to manage the acute pain or the chronic neuropathic pain related to paclitaxel. In the present study, we evaluated the analgesic potential of two N-type voltage-gated calcium channel (VGCC) blockers, ω-conotoxin MVIIA and Phα1β, on acute and chronic pain induced by paclitaxel. Adult male rats were treated with four intraperitoneal injections of paclitaxel (1+1+1+1mg/kg, in alternate days) and the development of mechanical hyperalgesia was evaluated 24h (acute painful stage) or 15days (chronic painful stage) after the first paclitaxel injection. Not all animals showed mechanical hyperalgesia 24h after the first paclitaxel injection, but those that showed developed a more intense mechanical hyperalgesia at the chronic painful stage. Intrathecal administration (i.t.) of ω-conotoxin MVIIA (3-300pmol/site) or Phα1β (10-300pmol/site) reduced the mechanical hyperalgesia either at the acute or at the chronic painful stage induced by paclitaxel. When administered at the acute painful stage, ω-conotoxin MVIIA (300pmol/site, i.t.) and Phα1β (300pmol/site, i.t.) prevented the worsening of chronic mechanical hyperalgesia. Furthermore, Phα1β (30-300pmol/site, i.t.) elicited less adverse effects than ω-conotoxin MVIIA (10-300 pmol/site, i.t.). Taken together, our data evidence the involvement of N-type VGCC in pain sensitization induced by paclitaxel and point out the potential of Phα1β as a safer alternative than ω-conotoxin MVIIA to treat the pain related to paclitaxel.

Authors+Show Affiliations

Programa de Pós-graduação em Farmacologia Bioquímica e Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Núcleo de Pós-graduação, Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24148893

Citation

Rigo, Flávia K., et al. "Effect of Ω-conotoxin MVIIA and Phα1β On Paclitaxel-induced Acute and Chronic Pain." Pharmacology, Biochemistry, and Behavior, vol. 114-115, 2013, pp. 16-22.
Rigo FK, Dalmolin GD, Trevisan G, et al. Effect of ω-conotoxin MVIIA and Phα1β on paclitaxel-induced acute and chronic pain. Pharmacol Biochem Behav. 2013;114-115:16-22.
Rigo, F. K., Dalmolin, G. D., Trevisan, G., Tonello, R., Silva, M. A., Rossato, M. F., Klafke, J. Z., Cordeiro, M. d. o. . N., Castro Junior, C. J., Montijo, D., Gomez, M. V., & Ferreira, J. (2013). Effect of ω-conotoxin MVIIA and Phα1β on paclitaxel-induced acute and chronic pain. Pharmacology, Biochemistry, and Behavior, 114-115, 16-22. https://doi.org/10.1016/j.pbb.2013.10.014
Rigo FK, et al. Effect of Ω-conotoxin MVIIA and Phα1β On Paclitaxel-induced Acute and Chronic Pain. Pharmacol Biochem Behav. 2013;114-115:16-22. PubMed PMID: 24148893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ω-conotoxin MVIIA and Phα1β on paclitaxel-induced acute and chronic pain. AU - Rigo,Flávia K, AU - Dalmolin,Gerusa D, AU - Trevisan,Gabriela, AU - Tonello,Raquel, AU - Silva,Mariane A, AU - Rossato,Mateus F, AU - Klafke,Jonatas Z, AU - Cordeiro,Marta do N, AU - Castro Junior,Célio J, AU - Montijo,Danuza, AU - Gomez,Marcus V, AU - Ferreira,Juliano, Y1 - 2013/10/19/ PY - 2013/04/24/received PY - 2013/08/31/revised PY - 2013/10/11/accepted PY - 2013/10/24/entrez PY - 2013/10/24/pubmed PY - 2014/7/23/medline KW - Calcium channel blockers KW - Chemotherapy KW - Neuropathy KW - Peptide toxins KW - Phoneutria nigriventer SP - 16 EP - 22 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 114-115 N2 - The treatment with the chemotherapeutic agent paclitaxel produces a painful peripheral neuropathy, and is associated with an acute pain syndrome in a clinically significant number of patients. However, no standard therapy has been established to manage the acute pain or the chronic neuropathic pain related to paclitaxel. In the present study, we evaluated the analgesic potential of two N-type voltage-gated calcium channel (VGCC) blockers, ω-conotoxin MVIIA and Phα1β, on acute and chronic pain induced by paclitaxel. Adult male rats were treated with four intraperitoneal injections of paclitaxel (1+1+1+1mg/kg, in alternate days) and the development of mechanical hyperalgesia was evaluated 24h (acute painful stage) or 15days (chronic painful stage) after the first paclitaxel injection. Not all animals showed mechanical hyperalgesia 24h after the first paclitaxel injection, but those that showed developed a more intense mechanical hyperalgesia at the chronic painful stage. Intrathecal administration (i.t.) of ω-conotoxin MVIIA (3-300pmol/site) or Phα1β (10-300pmol/site) reduced the mechanical hyperalgesia either at the acute or at the chronic painful stage induced by paclitaxel. When administered at the acute painful stage, ω-conotoxin MVIIA (300pmol/site, i.t.) and Phα1β (300pmol/site, i.t.) prevented the worsening of chronic mechanical hyperalgesia. Furthermore, Phα1β (30-300pmol/site, i.t.) elicited less adverse effects than ω-conotoxin MVIIA (10-300 pmol/site, i.t.). Taken together, our data evidence the involvement of N-type VGCC in pain sensitization induced by paclitaxel and point out the potential of Phα1β as a safer alternative than ω-conotoxin MVIIA to treat the pain related to paclitaxel. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/24148893/Effect_of_��_conotoxin_MVIIA_and_Ph��1��_on_paclitaxel_induced_acute_and_chronic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(13)00260-8 DB - PRIME DP - Unbound Medicine ER -