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Nut consumption and risk of pancreatic cancer in women.
Br J Cancer. 2013 Nov 26; 109(11):2911-6.BJ

Abstract

BACKGROUND

Increasing nut intake has been associated with reduced risk of diabetes mellitus, which is a risk factor for pancreatic cancer.

METHODS

We prospectively followed 75 680 women in the Nurses' Health Study, and examined the association between nut consumption and pancreatic cancer risk. Participants with a previous history of cancer were excluded. Nut consumption was assessed at baseline and updated every 2 to 4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models.

RESULTS

We documented 466 incident cases of pancreatic cancer. After adjusting for age, height, smoking, physical activity, and total energy intake, women who consumed a 28-g (1 oz) serving size of nuts ≥2 times per week experienced a significantly lower risk of pancreatic cancer (RR, 0.65; 95% CI, 0.47-0.92; P for trend=0.007) when compared with those who largely abstained from nuts. The results did not appreciably change after further adjustment for body mass index (BMI) and history of diabetes mellitus (RR, 0.68; 95% CI, 0.48-0.95; P for trend=0.01). The inverse association persisted within strata defined by BMI, physical activity, smoking, and intakes of red meat, fruits, and vegetables.

CONCLUSION

Frequent nut consumption is inversely associated with risk of pancreatic cancer in this large prospective cohort of women, independent of other potential risk factors for pancreatic cancer.

Authors+Show Affiliations

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24149179

Citation

Bao, Y, et al. "Nut Consumption and Risk of Pancreatic Cancer in Women." British Journal of Cancer, vol. 109, no. 11, 2013, pp. 2911-6.
Bao Y, Hu FB, Giovannucci EL, et al. Nut consumption and risk of pancreatic cancer in women. Br J Cancer. 2013;109(11):2911-6.
Bao, Y., Hu, F. B., Giovannucci, E. L., Wolpin, B. M., Stampfer, M. J., Willett, W. C., & Fuchs, C. S. (2013). Nut consumption and risk of pancreatic cancer in women. British Journal of Cancer, 109(11), 2911-6. https://doi.org/10.1038/bjc.2013.665
Bao Y, et al. Nut Consumption and Risk of Pancreatic Cancer in Women. Br J Cancer. 2013 Nov 26;109(11):2911-6. PubMed PMID: 24149179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nut consumption and risk of pancreatic cancer in women. AU - Bao,Y, AU - Hu,F B, AU - Giovannucci,E L, AU - Wolpin,B M, AU - Stampfer,M J, AU - Willett,W C, AU - Fuchs,C S, Y1 - 2013/10/22/ PY - 2013/07/10/received PY - 2013/09/24/revised PY - 2013/10/02/accepted PY - 2013/10/24/entrez PY - 2013/10/24/pubmed PY - 2014/2/12/medline SP - 2911 EP - 6 JF - British journal of cancer JO - Br. J. Cancer VL - 109 IS - 11 N2 - BACKGROUND: Increasing nut intake has been associated with reduced risk of diabetes mellitus, which is a risk factor for pancreatic cancer. METHODS: We prospectively followed 75 680 women in the Nurses' Health Study, and examined the association between nut consumption and pancreatic cancer risk. Participants with a previous history of cancer were excluded. Nut consumption was assessed at baseline and updated every 2 to 4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models. RESULTS: We documented 466 incident cases of pancreatic cancer. After adjusting for age, height, smoking, physical activity, and total energy intake, women who consumed a 28-g (1 oz) serving size of nuts ≥2 times per week experienced a significantly lower risk of pancreatic cancer (RR, 0.65; 95% CI, 0.47-0.92; P for trend=0.007) when compared with those who largely abstained from nuts. The results did not appreciably change after further adjustment for body mass index (BMI) and history of diabetes mellitus (RR, 0.68; 95% CI, 0.48-0.95; P for trend=0.01). The inverse association persisted within strata defined by BMI, physical activity, smoking, and intakes of red meat, fruits, and vegetables. CONCLUSION: Frequent nut consumption is inversely associated with risk of pancreatic cancer in this large prospective cohort of women, independent of other potential risk factors for pancreatic cancer. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/24149179/Nut_consumption_and_risk_of_pancreatic_cancer_in_women_ L2 - http://dx.doi.org/10.1038/bjc.2013.665 DB - PRIME DP - Unbound Medicine ER -