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Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women.
Menopause 2014; 21(6):653-60M

Abstract

OBJECTIVE

Dietary supplements containing soy or isoflavones are widely used as alternatives to hormone therapy. However, their efficacy is still inconclusive, and limited data on equol producers are available. The aim of this study was to examine the effect of whole soy (soy flour) or purified daidzein (one major soy isoflavone and the precursor of equol) on menopausal symptoms in equol-producing postmenopausal women, a population most likely to benefit from soy intervention.

METHODS

This is a 6-month parallel-group, double-blind, randomized, placebo-controlled trial. Two hundred seventy equol-producing prehypertensive Chinese postmenopausal women were randomized to one of three treatment groups: 40 g of soy flour (whole soy group), 40 g of low-fat milk powder + 63 mg of daidzein (daidzein group), or 40 g of low-fat milk powder (placebo group) daily, each given as a solid beverage for 6 months. Changes in menopausal symptoms were assessed by a validated and structured symptom checklist at baseline and 6 months.

RESULTS

Two hundred fifty-three participants completed the study according to protocol. Urinary isoflavones indicated good compliance with the interventions. Baseline menopausal symptoms were comparable among the three study groups. Intention-to-treat analysis indicated that there was no significant difference in the 6-month changes or percent changes in the total number of menopausal symptoms, in the five dimensions of symptoms, and in the frequencies of individual symptoms among the three treatment groups.

CONCLUSIONS

Whole soy and purified daidzein have no significant effect on alleviation of menopausal symptoms among equol-producing postmenopausal women with prehypertension.

Authors+Show Affiliations

From the 1Department of Medicine and Therapeutics, and 2Division of Epidemiology, The Jockey Club of the School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR; 3Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, PR China; and 4Center of Research and Promotion of Women's Health, The Jockey Club of the School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24149925

Citation

Liu, Zhao-min, et al. "Randomized Controlled Trial of Whole Soy and Isoflavone Daidzein On Menopausal Symptoms in Equol-producing Chinese Postmenopausal Women." Menopause (New York, N.Y.), vol. 21, no. 6, 2014, pp. 653-60.
Liu ZM, Ho SC, Woo J, et al. Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women. Menopause. 2014;21(6):653-60.
Liu, Z. M., Ho, S. C., Woo, J., Chen, Y. M., & Wong, C. (2014). Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women. Menopause (New York, N.Y.), 21(6), pp. 653-60. doi:10.1097/GME.0000000000000102.
Liu ZM, et al. Randomized Controlled Trial of Whole Soy and Isoflavone Daidzein On Menopausal Symptoms in Equol-producing Chinese Postmenopausal Women. Menopause. 2014;21(6):653-60. PubMed PMID: 24149925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women. AU - Liu,Zhao-min, AU - Ho,Suzanne C, AU - Woo,Jean, AU - Chen,Yu-ming, AU - Wong,Carmen, PY - 2013/10/24/entrez PY - 2013/10/24/pubmed PY - 2015/2/20/medline SP - 653 EP - 60 JF - Menopause (New York, N.Y.) JO - Menopause VL - 21 IS - 6 N2 - OBJECTIVE: Dietary supplements containing soy or isoflavones are widely used as alternatives to hormone therapy. However, their efficacy is still inconclusive, and limited data on equol producers are available. The aim of this study was to examine the effect of whole soy (soy flour) or purified daidzein (one major soy isoflavone and the precursor of equol) on menopausal symptoms in equol-producing postmenopausal women, a population most likely to benefit from soy intervention. METHODS: This is a 6-month parallel-group, double-blind, randomized, placebo-controlled trial. Two hundred seventy equol-producing prehypertensive Chinese postmenopausal women were randomized to one of three treatment groups: 40 g of soy flour (whole soy group), 40 g of low-fat milk powder + 63 mg of daidzein (daidzein group), or 40 g of low-fat milk powder (placebo group) daily, each given as a solid beverage for 6 months. Changes in menopausal symptoms were assessed by a validated and structured symptom checklist at baseline and 6 months. RESULTS: Two hundred fifty-three participants completed the study according to protocol. Urinary isoflavones indicated good compliance with the interventions. Baseline menopausal symptoms were comparable among the three study groups. Intention-to-treat analysis indicated that there was no significant difference in the 6-month changes or percent changes in the total number of menopausal symptoms, in the five dimensions of symptoms, and in the frequencies of individual symptoms among the three treatment groups. CONCLUSIONS: Whole soy and purified daidzein have no significant effect on alleviation of menopausal symptoms among equol-producing postmenopausal women with prehypertension. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/24149925/Randomized_controlled_trial_of_whole_soy_and_isoflavone_daidzein_on_menopausal_symptoms_in_equol_producing_Chinese_postmenopausal_women_ L2 - http://Insights.ovid.com/pubmed?pmid=24149925 DB - PRIME DP - Unbound Medicine ER -