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Catalytic asymmetric aldol reactions in aqueous media--a 5 year update.
Chem Soc Rev. 2014 Jan 21; 43(2):577-87.CS

Abstract

Asymmetric reactions in water and in aqueous solutions have become an area of fast growing interest recently. Although for a long time neglected as a medium for organic reactions, water has attracted attention as the most widely distributed solvent in the world. Indeed, water is the solvent used by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeogenesis and related processes. Consequently, artificial catalysts designed and used for aldol reactions in water can be promising for the synthesis of enantiopure molecules and are also important for the understanding of complex chemistry of life. This tutorial review summarizes recent developments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions--development of water compatible chiral Lewis acids and amine-based organocatalysts.

Authors+Show Affiliations

Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland. jacek.mlynarski@gmail.com.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24150484

Citation

Mlynarski, Jacek, and Sebastian Baś. "Catalytic Asymmetric Aldol Reactions in Aqueous Media--a 5 Year Update." Chemical Society Reviews, vol. 43, no. 2, 2014, pp. 577-87.
Mlynarski J, Baś S. Catalytic asymmetric aldol reactions in aqueous media--a 5 year update. Chem Soc Rev. 2014;43(2):577-87.
Mlynarski, J., & Baś, S. (2014). Catalytic asymmetric aldol reactions in aqueous media--a 5 year update. Chemical Society Reviews, 43(2), 577-87. https://doi.org/10.1039/c3cs60202h
Mlynarski J, Baś S. Catalytic Asymmetric Aldol Reactions in Aqueous Media--a 5 Year Update. Chem Soc Rev. 2014 Jan 21;43(2):577-87. PubMed PMID: 24150484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Catalytic asymmetric aldol reactions in aqueous media--a 5 year update. AU - Mlynarski,Jacek, AU - Baś,Sebastian, PY - 2013/10/24/entrez PY - 2013/10/24/pubmed PY - 2013/10/24/medline SP - 577 EP - 87 JF - Chemical Society reviews JO - Chem Soc Rev VL - 43 IS - 2 N2 - Asymmetric reactions in water and in aqueous solutions have become an area of fast growing interest recently. Although for a long time neglected as a medium for organic reactions, water has attracted attention as the most widely distributed solvent in the world. Indeed, water is the solvent used by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeogenesis and related processes. Consequently, artificial catalysts designed and used for aldol reactions in water can be promising for the synthesis of enantiopure molecules and are also important for the understanding of complex chemistry of life. This tutorial review summarizes recent developments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions--development of water compatible chiral Lewis acids and amine-based organocatalysts. SN - 1460-4744 UR - https://www.unboundmedicine.com/medline/citation/24150484/Catalytic_asymmetric_aldol_reactions_in_aqueous_media__a_5_year_update_ L2 - https://doi.org/10.1039/c3cs60202h DB - PRIME DP - Unbound Medicine ER -
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