Tags

Type your tag names separated by a space and hit enter

MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study.
Endocr Res 2014; 39(3):115-9ER

Abstract

BACKGROUND

Type 2 diabetes (T2D) is among the leading public health problems in Japan, and glycated hemoglobin (HbA1c) can be used to screen the population for T2D. Gene polymorphisms, known to be associated with obesity, may predispose individuals to T2D. Rs17782313 the melanocortin 4 receptor (MC4R) has shown one of the strongest associations with body mass index (BMI). We conducted a study to investigate whether rs17782313 (TT versus TC + CC) was associated with HbA1c.

METHOD

We conducted a cross-sectional study including 1142 Japanese adults (446 men: 64.9 ± 14.4 years and 696 women: 66.7 ± 12.3 years). MC4R rs17782313 was genotyped using fast real-time polymerase chain reaction.

RESULTS

TC + CC genotype group showed significantly greater BMI (p = 0.039) and HbA1c (p = 0.001) than TT genotype group after adjustment for gender, age and, for HbA1c, BMI. Further analysis using linear regression analysis confirmed that the effect of MC4R rs17782313 on HbA1c (β = 0.08; p = 0.003) was independent of the effect age, gender, BMI, low density lipoprotein cholesterol, homeostasis model assessment of insulin resistance and of beta cell function. This significant independent association was similarly noticed in non-obese (β = 2.82; p = 0.005) subgroups.

CONCLUSION

MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.

Authors+Show Affiliations

Department of Environmental & Preventive Medicine, Shimane University School of Medicine , Shimane , Japan .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24151814

Citation

Mutombo, Paulin Beya wa Bitadi, et al. "MC4R Rs17782313 Gene Polymorphism Was Associated With Glycated Hemoglobin Independently of Its Effect On BMI in Japanese: the Shimane COHRE Study." Endocrine Research, vol. 39, no. 3, 2014, pp. 115-9.
Mutombo PB, Yamasaki M, Hamano T, et al. MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study. Endocr Res. 2014;39(3):115-9.
Mutombo, P. B., Yamasaki, M., Hamano, T., Isomura, M., Nabika, T., & Shiwaku, K. (2014). MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study. Endocrine Research, 39(3), pp. 115-9. doi:10.3109/07435800.2013.844163.
Mutombo PB, et al. MC4R Rs17782313 Gene Polymorphism Was Associated With Glycated Hemoglobin Independently of Its Effect On BMI in Japanese: the Shimane COHRE Study. Endocr Res. 2014;39(3):115-9. PubMed PMID: 24151814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study. AU - Mutombo,Paulin Beya wa Bitadi, AU - Yamasaki,Masayuki, AU - Hamano,Tsuyoshi, AU - Isomura,Minoru, AU - Nabika,Toru, AU - Shiwaku,Kuninori, Y1 - 2013/10/23/ PY - 2013/10/25/entrez PY - 2013/10/25/pubmed PY - 2015/1/21/medline KW - Inflammation KW - insulin resistance KW - insulin secretion KW - obesity KW - single nucleotide polymorphism KW - type 2 diabetes SP - 115 EP - 9 JF - Endocrine research JO - Endocr. Res. VL - 39 IS - 3 N2 - BACKGROUND: Type 2 diabetes (T2D) is among the leading public health problems in Japan, and glycated hemoglobin (HbA1c) can be used to screen the population for T2D. Gene polymorphisms, known to be associated with obesity, may predispose individuals to T2D. Rs17782313 the melanocortin 4 receptor (MC4R) has shown one of the strongest associations with body mass index (BMI). We conducted a study to investigate whether rs17782313 (TT versus TC + CC) was associated with HbA1c. METHOD: We conducted a cross-sectional study including 1142 Japanese adults (446 men: 64.9 ± 14.4 years and 696 women: 66.7 ± 12.3 years). MC4R rs17782313 was genotyped using fast real-time polymerase chain reaction. RESULTS: TC + CC genotype group showed significantly greater BMI (p = 0.039) and HbA1c (p = 0.001) than TT genotype group after adjustment for gender, age and, for HbA1c, BMI. Further analysis using linear regression analysis confirmed that the effect of MC4R rs17782313 on HbA1c (β = 0.08; p = 0.003) was independent of the effect age, gender, BMI, low density lipoprotein cholesterol, homeostasis model assessment of insulin resistance and of beta cell function. This significant independent association was similarly noticed in non-obese (β = 2.82; p = 0.005) subgroups. CONCLUSION: MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect. SN - 1532-4206 UR - https://www.unboundmedicine.com/medline/citation/24151814/MC4R_rs17782313_gene_polymorphism_was_associated_with_glycated_hemoglobin_independently_of_its_effect_on_BMI_in_Japanese:_the_Shimane_COHRE_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/07435800.2013.844163 DB - PRIME DP - Unbound Medicine ER -