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The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential.
Br Med Bull 2013; 108:25-53BM

Abstract

BACKGROUND

Blood vessel formation is fundamental to development, while its dysregulation can contribute to serious disease. Expectations are that hundreds of millions of individuals will benefit from therapeutic developments in vascular biology. MSCs are central to the three main vascular repair mechanisms.

SOURCES OF DATA

Key recent published literature and ClinicalTrials.gov.

AREAS OF AGREEMENT

MSCs are heterogeneous, containing multi-lineage stem and partly differentiated progenitor cells, and are easily expandable ex vivo. There is no single marker defining native MSCs in vivo. Their phenotype is strongly determined by their specific microenvironment. Bone marrow MSCs have skeletal stem cell properties. Having a perivascular/vascular location, they contribute to vascular formation and function and might be harnessed to regenerate a blood supply to injured tissues.

AREAS OF CONTROVERSY

These include MSC origin, phenotype and location in vivo and their ability to differentiate into functional cardiomyocytes and endothelial cells or act as vascular stem cells. In addition their efficacy, safety and potency in clinical trials in relation to cell source, dose, delivery route, passage and timing of administration, but probably even more on the local preconditioning and the mechanisms by which they exert their effects.

GROWING POINTS

Understanding the origin and the regenerative environment of MSCs, and manipulating their homing properties, proliferative ability and functionality through drug discovery and reprogramming strategies are important for their efficacy in vascular repair for regenerative medicine therapies and tissue engineering approaches.

AREAS TIMELY FOR DEVELOPING RESEARCH

Characterization of MSCs' in vivo origins and biological properties in relation to their localization within tissue niches, reprogramming strategies and newer imaging/bioengineering approaches.

Authors+Show Affiliations

Stem Cell Research Laboratory, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24152971

Citation

Watt, Suzanne M., et al. "The Angiogenic Properties of Mesenchymal Stem/stromal Cells and Their Therapeutic Potential." British Medical Bulletin, vol. 108, 2013, pp. 25-53.
Watt SM, Gullo F, van der Garde M, et al. The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. Br Med Bull. 2013;108:25-53.
Watt, S. M., Gullo, F., van der Garde, M., Markeson, D., Camicia, R., Khoo, C. P., & Zwaginga, J. J. (2013). The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. British Medical Bulletin, 108, pp. 25-53. doi:10.1093/bmb/ldt031.
Watt SM, et al. The Angiogenic Properties of Mesenchymal Stem/stromal Cells and Their Therapeutic Potential. Br Med Bull. 2013;108:25-53. PubMed PMID: 24152971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. AU - Watt,Suzanne M, AU - Gullo,Francesca, AU - van der Garde,Mark, AU - Markeson,Daniel, AU - Camicia,Rosalba, AU - Khoo,Cheen P, AU - Zwaginga,Jaap Jan, Y1 - 2013/10/23/ PY - 2013/10/25/entrez PY - 2013/10/25/pubmed PY - 2014/7/31/medline KW - adventitial cells KW - angiogenesis KW - arteriogenesis KW - cancer KW - mesenchymal stem/stromal cells KW - pericytes KW - regenerative medicine KW - tissue engineering KW - transplantation KW - vasculogenesis SP - 25 EP - 53 JF - British medical bulletin JO - Br. Med. Bull. VL - 108 N2 - BACKGROUND: Blood vessel formation is fundamental to development, while its dysregulation can contribute to serious disease. Expectations are that hundreds of millions of individuals will benefit from therapeutic developments in vascular biology. MSCs are central to the three main vascular repair mechanisms. SOURCES OF DATA: Key recent published literature and ClinicalTrials.gov. AREAS OF AGREEMENT: MSCs are heterogeneous, containing multi-lineage stem and partly differentiated progenitor cells, and are easily expandable ex vivo. There is no single marker defining native MSCs in vivo. Their phenotype is strongly determined by their specific microenvironment. Bone marrow MSCs have skeletal stem cell properties. Having a perivascular/vascular location, they contribute to vascular formation and function and might be harnessed to regenerate a blood supply to injured tissues. AREAS OF CONTROVERSY: These include MSC origin, phenotype and location in vivo and their ability to differentiate into functional cardiomyocytes and endothelial cells or act as vascular stem cells. In addition their efficacy, safety and potency in clinical trials in relation to cell source, dose, delivery route, passage and timing of administration, but probably even more on the local preconditioning and the mechanisms by which they exert their effects. GROWING POINTS: Understanding the origin and the regenerative environment of MSCs, and manipulating their homing properties, proliferative ability and functionality through drug discovery and reprogramming strategies are important for their efficacy in vascular repair for regenerative medicine therapies and tissue engineering approaches. AREAS TIMELY FOR DEVELOPING RESEARCH: Characterization of MSCs' in vivo origins and biological properties in relation to their localization within tissue niches, reprogramming strategies and newer imaging/bioengineering approaches. SN - 1471-8391 UR - https://www.unboundmedicine.com/medline/citation/24152971/The_angiogenic_properties_of_mesenchymal_stem/stromal_cells_and_their_therapeutic_potential_ L2 - https://academic.oup.com/bmb/article-lookup/doi/10.1093/bmb/ldt031 DB - PRIME DP - Unbound Medicine ER -