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Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children.
Pediatr Res. 2013 Nov; 74(5):584-91.PR

Abstract

BACKGROUND

Cysteinyl leukotrienes are important mediators of airway inflammation, whereas 8-isoprostane is a biomarker of oxidative stress. This study evaluated the distributions of cysteinyl leukotriene and 8-isoprostane concentrations in exhaled breath condensates (EBCs) of children. The relationship between cysteinyl leukotriene and 8-isoprostane concentrations in the EBCs was also evaluated.

METHODS

The EBCs were collected from 34 children with allergic respiratory diseases and 24 healthy children. All recruited children underwent pulmonary function testing every season. The severity of allergic respiratory diseases and medication status were assessed every month in children with allergic respiratory diseases.

RESULTS

The EBC cysteinyl leukotriene and 8-isoprostane levels were higher in children with asthma and allergic rhinitis than in those with asthma only and healthy children. In asthmatic children, cysteinyl leukotriene and 8-isoprostane levels peaked in the summer. All children showed a clear association between EBC cysteinyl leukotriene and EBC 8-isoprostane levels.

CONCLUSION

The cysteinyl leukotriene and 8-isoprostane concentrations in the EBCs of children significantly varied by season. Oxidative stress correlated with airway inflammation in children.

Authors+Show Affiliations

Department of Respiratory Therapy, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24153334

Citation

Wan, Gwo-Hwa, et al. "Cysteinyl Leukotriene Levels Correlate With 8-isoprostane Levels in Exhaled Breath Condensates of Atopic and Healthy Children." Pediatric Research, vol. 74, no. 5, 2013, pp. 584-91.
Wan GH, Yan DC, Tseng HY, et al. Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children. Pediatr Res. 2013;74(5):584-91.
Wan, G. H., Yan, D. C., Tseng, H. Y., Tung, T. H., Lin, S. J., & Lin, Y. W. (2013). Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children. Pediatric Research, 74(5), 584-91. https://doi.org/10.1038/pr.2013.142
Wan GH, et al. Cysteinyl Leukotriene Levels Correlate With 8-isoprostane Levels in Exhaled Breath Condensates of Atopic and Healthy Children. Pediatr Res. 2013;74(5):584-91. PubMed PMID: 24153334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children. AU - Wan,Gwo-Hwa, AU - Yan,Dah-Chin, AU - Tseng,Hui-Yun, AU - Tung,Tao-Hsin, AU - Lin,Syh-Jae, AU - Lin,Yu-Wen, Y1 - 2013/09/02/ PY - 2012/11/26/received PY - 2013/04/03/accepted PY - 2013/10/25/entrez PY - 2013/10/25/pubmed PY - 2014/6/17/medline SP - 584 EP - 91 JF - Pediatric research JO - Pediatr Res VL - 74 IS - 5 N2 - BACKGROUND: Cysteinyl leukotrienes are important mediators of airway inflammation, whereas 8-isoprostane is a biomarker of oxidative stress. This study evaluated the distributions of cysteinyl leukotriene and 8-isoprostane concentrations in exhaled breath condensates (EBCs) of children. The relationship between cysteinyl leukotriene and 8-isoprostane concentrations in the EBCs was also evaluated. METHODS: The EBCs were collected from 34 children with allergic respiratory diseases and 24 healthy children. All recruited children underwent pulmonary function testing every season. The severity of allergic respiratory diseases and medication status were assessed every month in children with allergic respiratory diseases. RESULTS: The EBC cysteinyl leukotriene and 8-isoprostane levels were higher in children with asthma and allergic rhinitis than in those with asthma only and healthy children. In asthmatic children, cysteinyl leukotriene and 8-isoprostane levels peaked in the summer. All children showed a clear association between EBC cysteinyl leukotriene and EBC 8-isoprostane levels. CONCLUSION: The cysteinyl leukotriene and 8-isoprostane concentrations in the EBCs of children significantly varied by season. Oxidative stress correlated with airway inflammation in children. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/24153334/Cysteinyl_leukotriene_levels_correlate_with_8_isoprostane_levels_in_exhaled_breath_condensates_of_atopic_and_healthy_children_ L2 - https://doi.org/10.1038/pr.2013.142 DB - PRIME DP - Unbound Medicine ER -