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Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group.
Org Lett. 2013 Nov 15; 15(22):5750-3.OL

Abstract

An efficient and mechanistically interesting method for the synthesis of highly substituted isoquinolines by a Rh(III)-catalyzed hydrazone directed ortho C-H bond activation and annulation without an external oxidant is described. This reaction is accomplished via a C-C and C-N bond formation along with N-N bond cleavage.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chuang SC
Department of Chemistry, National Tsing Hua University , Hsinchu 30013, Taiwan.
Gandeepan P
No affiliation info available
Cheng CH
No affiliation info available

MeSH

CatalysisHydrazonesHydrogen BondingIsoquinolinesMolecular StructureRhodium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24156564

Citation

Chuang, Sheng-Chieh, et al. "Synthesis of Isoquinolines Via Rh(III)-catalyzed C-H Activation Using Hydrazone as a New Oxidizing Directing Group." Organic Letters, vol. 15, no. 22, 2013, pp. 5750-3.
Chuang SC, Gandeepan P, Cheng CH. Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group. Org Lett. 2013;15(22):5750-3.
Chuang, S. C., Gandeepan, P., & Cheng, C. H. (2013). Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group. Organic Letters, 15(22), 5750-3. https://doi.org/10.1021/ol402796m
Chuang SC, Gandeepan P, Cheng CH. Synthesis of Isoquinolines Via Rh(III)-catalyzed C-H Activation Using Hydrazone as a New Oxidizing Directing Group. Org Lett. 2013 Nov 15;15(22):5750-3. PubMed PMID: 24156564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group. AU - Chuang,Sheng-Chieh, AU - Gandeepan,Parthasarathy, AU - Cheng,Chien-Hong, Y1 - 2013/10/24/ PY - 2013/10/26/entrez PY - 2013/10/26/pubmed PY - 2014/4/20/medline SP - 5750 EP - 3 JF - Organic letters JO - Org Lett VL - 15 IS - 22 N2 - An efficient and mechanistically interesting method for the synthesis of highly substituted isoquinolines by a Rh(III)-catalyzed hydrazone directed ortho C-H bond activation and annulation without an external oxidant is described. This reaction is accomplished via a C-C and C-N bond formation along with N-N bond cleavage. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/24156564/Synthesis_of_isoquinolines_via_Rh_III__catalyzed_C_H_activation_using_hydrazone_as_a_new_oxidizing_directing_group_ L2 - https://doi.org/10.1021/ol402796m DB - PRIME DP - Unbound Medicine ER -