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Plasma kinetics of chylomicron-like emulsion and lipid transfers to high-density lipoprotein (HDL) in lacto-ovo vegetarian and in omnivorous subjects.
Eur J Nutr. 2014 Apr; 53(3):981-7.EJ

Abstract

PURPOSE

Previously, it was showed that vegan diet improves the metabolism of triglyceride-rich lipoproteins by increasing the plasma clearance of atherogenic remnants. The aim of the current study was to investigate this metabolism in lacto-ovo vegetarians whose diet is less strict, allowing the ingestion of eggs and milk. Transfer of lipids to HDL, an important step in HDL metabolism, was tested in vitro.

METHODS

Eighteen lacto-ovo vegetarians and 29 omnivorous subjects, all eutrophic and normolipidemic, were intravenously injected with triglyceride-rich emulsions labeled with ¹⁴C-cholesterol oleate and ³H-triolein. Fractional clearance rates (FCR, in min⁻¹) were calculated from samples collected during 60 min. Lipid transfer to HDL was assayed by incubating plasma samples with a donor nanoemulsion labeled with radioactive lipids.

RESULTS

LDL cholesterol was lower in vegetarians than in omnivores (2.1 ± 0.8 and 2.7 ± 0.7 mmol/L, respectively, p < 0.05), but HDL cholesterol and triglycerides were equal. Cholesteryl ester FCR was greater in vegetarians than in omnivores (0.016 ± 0.012, 0.003 ± 0.003, p < 0.01), whereas triglyceride FCR was equal. Cholesteryl ester transfer to HDL was lower in vegetarians than in omnivores (2.7 ± 0.6, 3.5 ± 1.5 %, p < 0.05), but free cholesterol, triglyceride and phospholipid transfers and HDL size were equal.

CONCLUSION

Similarly to vegans, lacto-ovo vegetarian diet increases remnant removal, as indicated by cholesteryl oleate FCR, which may favor atherosclerosis prevention, and has the ability to change lipid transfer to HDL.

Authors+Show Affiliations

Heart Institute (InCor) of the Medical School Hospital, University of São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24158652

Citation

Vinagre, Juliana C., et al. "Plasma Kinetics of Chylomicron-like Emulsion and Lipid Transfers to High-density Lipoprotein (HDL) in Lacto-ovo Vegetarian and in Omnivorous Subjects." European Journal of Nutrition, vol. 53, no. 3, 2014, pp. 981-7.
Vinagre JC, Vinagre CC, Pozzi FS, et al. Plasma kinetics of chylomicron-like emulsion and lipid transfers to high-density lipoprotein (HDL) in lacto-ovo vegetarian and in omnivorous subjects. Eur J Nutr. 2014;53(3):981-7.
Vinagre, J. C., Vinagre, C. C., Pozzi, F. S., Zácari, C. Z., & Maranhão, R. C. (2014). Plasma kinetics of chylomicron-like emulsion and lipid transfers to high-density lipoprotein (HDL) in lacto-ovo vegetarian and in omnivorous subjects. European Journal of Nutrition, 53(3), 981-7. https://doi.org/10.1007/s00394-013-0602-y
Vinagre JC, et al. Plasma Kinetics of Chylomicron-like Emulsion and Lipid Transfers to High-density Lipoprotein (HDL) in Lacto-ovo Vegetarian and in Omnivorous Subjects. Eur J Nutr. 2014;53(3):981-7. PubMed PMID: 24158652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma kinetics of chylomicron-like emulsion and lipid transfers to high-density lipoprotein (HDL) in lacto-ovo vegetarian and in omnivorous subjects. AU - Vinagre,Juliana C, AU - Vinagre,Carmen C G, AU - Pozzi,Fernanda S, AU - Zácari,Cristiane Z, AU - Maranhão,Raul C, Y1 - 2013/10/26/ PY - 2013/07/01/received PY - 2013/10/08/accepted PY - 2013/10/26/entrez PY - 2013/10/26/pubmed PY - 2015/2/13/medline SP - 981 EP - 7 JF - European journal of nutrition JO - Eur J Nutr VL - 53 IS - 3 N2 - PURPOSE: Previously, it was showed that vegan diet improves the metabolism of triglyceride-rich lipoproteins by increasing the plasma clearance of atherogenic remnants. The aim of the current study was to investigate this metabolism in lacto-ovo vegetarians whose diet is less strict, allowing the ingestion of eggs and milk. Transfer of lipids to HDL, an important step in HDL metabolism, was tested in vitro. METHODS: Eighteen lacto-ovo vegetarians and 29 omnivorous subjects, all eutrophic and normolipidemic, were intravenously injected with triglyceride-rich emulsions labeled with ¹⁴C-cholesterol oleate and ³H-triolein. Fractional clearance rates (FCR, in min⁻¹) were calculated from samples collected during 60 min. Lipid transfer to HDL was assayed by incubating plasma samples with a donor nanoemulsion labeled with radioactive lipids. RESULTS: LDL cholesterol was lower in vegetarians than in omnivores (2.1 ± 0.8 and 2.7 ± 0.7 mmol/L, respectively, p < 0.05), but HDL cholesterol and triglycerides were equal. Cholesteryl ester FCR was greater in vegetarians than in omnivores (0.016 ± 0.012, 0.003 ± 0.003, p < 0.01), whereas triglyceride FCR was equal. Cholesteryl ester transfer to HDL was lower in vegetarians than in omnivores (2.7 ± 0.6, 3.5 ± 1.5 %, p < 0.05), but free cholesterol, triglyceride and phospholipid transfers and HDL size were equal. CONCLUSION: Similarly to vegans, lacto-ovo vegetarian diet increases remnant removal, as indicated by cholesteryl oleate FCR, which may favor atherosclerosis prevention, and has the ability to change lipid transfer to HDL. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/24158652/Plasma_kinetics_of_chylomicron_like_emulsion_and_lipid_transfers_to_high_density_lipoprotein__HDL__in_lacto_ovo_vegetarian_and_in_omnivorous_subjects_ L2 - https://dx.doi.org/10.1007/s00394-013-0602-y DB - PRIME DP - Unbound Medicine ER -