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Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin.
Acta Derm Venereol. 1985; 65(5):409-12.AD

Abstract

Cutaneous pruritic effects of synthetic platelet activating factor (PAF-acether) and, in particular, its interference with dermal mast cells, were studied in human volunteers. Intradermal injections of 10-100 ng produced dose-dependent flare and itching responses. The cutaneous reactions were inhibited by local administration of the H1 antihistamine mepyramin. The cutaneous responses were also markedly reduced in histamine-depleted skin. These findings indicate that the cutaneous responses produced by PAF-acether were mediated via an indirect and mainly histamine-dependent mechanism.

Authors

Fjellner B
No affiliation info available
Hägermark O
No affiliation info available

MeSH

AdultChemical PhenomenaChemistryDose-Response Relationship, DrugFemaleHistamineHumansMaleMiddle AgedPlatelet Activating FactorPruritusPyrilamineSkinp-Methoxy-N-methylphenethylamine

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2416164

Citation

Fjellner, B, and O Hägermark. "Experimental Pruritus Evoked By Platelet Activating Factor (PAF-acether) in Human Skin." Acta Dermato-venereologica, vol. 65, no. 5, 1985, pp. 409-12.
Fjellner B, Hägermark O. Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. Acta Derm Venereol. 1985;65(5):409-12.
Fjellner, B., & Hägermark, O. (1985). Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. Acta Dermato-venereologica, 65(5), 409-12.
Fjellner B, Hägermark O. Experimental Pruritus Evoked By Platelet Activating Factor (PAF-acether) in Human Skin. Acta Derm Venereol. 1985;65(5):409-12. PubMed PMID: 2416164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. AU - Fjellner,B, AU - Hägermark,O, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 409 EP - 12 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 65 IS - 5 N2 - Cutaneous pruritic effects of synthetic platelet activating factor (PAF-acether) and, in particular, its interference with dermal mast cells, were studied in human volunteers. Intradermal injections of 10-100 ng produced dose-dependent flare and itching responses. The cutaneous reactions were inhibited by local administration of the H1 antihistamine mepyramin. The cutaneous responses were also markedly reduced in histamine-depleted skin. These findings indicate that the cutaneous responses produced by PAF-acether were mediated via an indirect and mainly histamine-dependent mechanism. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/2416164/Experimental_pruritus_evoked_by_platelet_activating_factor__PAF_acether__in_human_skin_ DB - PRIME DP - Unbound Medicine ER -