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Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors.
Neurosci Lett. 2013 Dec 17; 557 Pt B:159-64.NL

Abstract

Studies have demonstrated the relationship between the histaminergic system and the cerebellum, and we intend to investigate the role of the cerebellar histaminergic system on memory consolidation. This study investigated the effect of intra-cerebellar microinjection of histamine on memory retention of inhibitory avoidance in mice, and the role of H1 and H2 receptors in it. The cerebellar vermis of male mice were implanted with guide cannulae, and after three days of recovery, the inhibitory avoidance test was performed. Immediately after a training session, animals received a microinjection of histaminergic drugs: in the experiment 1, saline (SAL) or histamine (HA 0.54, 1.36, 2.72 or 4.07 nmol); experiment 2, SAL or 1.36 nmol HA 5 min after a pretreatment with 0.16 nmol chlorpheniramine (CPA) or SAL; and experiment 3, SAL or 1.36 nmol HA 5 min after a pretreatment with 2.85 nmol ranitidine (RA) or SAL. Twenty-four hours later, a retention test was performed. The data were analyzed using one-way analysis of variance (ANOVA) and Duncan's tests. In experiment 1, animals microinjected with 1.36 nmol HA showed a higher latency to cross to the dark compartment compared to controls and to 2.72 and 4.07 nmol HA groups. In experiment 2, the combined infusions revealed difference between control (SAL+SAL) and SAL+HA and CPA+HA; while in the experiment 3 the analysis indicated differences in retention latency between mice injected with SAL+SAL and SAL+HA. The groups that received the H2 antagonist RA did not show difference compared to control. These results indicate that 1.36 nmol HA enhances memory consolidation of inhibitory avoidance learning in mice and that the pretreatment with H2 antagonist RA was able to prevent this effect.

Authors+Show Affiliations

Laboratory of Neuroscience, Physiotherapy Department, Center of Biological Sciences and Health, Federal University of Sao Carlos, 13565-905, Sao Carlos, Brazil. Electronic address: acgianlorenco@yahoo.com.br.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24161893

Citation

Gianlorenço, A C L., et al. "Intra-cerebellar Microinjection of Histamine Enhances Memory Consolidation of Inhibitory Avoidance Learning in Mice Via H2 Receptors." Neuroscience Letters, vol. 557 Pt B, 2013, pp. 159-64.
Gianlorenço AC, Canto-de-Souza A, Mattioli R. Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors. Neurosci Lett. 2013;557 Pt B:159-64.
Gianlorenço, A. C., Canto-de-Souza, A., & Mattioli, R. (2013). Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors. Neuroscience Letters, 557 Pt B, 159-64. https://doi.org/10.1016/j.neulet.2013.10.017
Gianlorenço AC, Canto-de-Souza A, Mattioli R. Intra-cerebellar Microinjection of Histamine Enhances Memory Consolidation of Inhibitory Avoidance Learning in Mice Via H2 Receptors. Neurosci Lett. 2013 Dec 17;557 Pt B:159-64. PubMed PMID: 24161893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intra-cerebellar microinjection of histamine enhances memory consolidation of inhibitory avoidance learning in mice via H2 receptors. AU - Gianlorenço,A C L, AU - Canto-de-Souza,A, AU - Mattioli,R, Y1 - 2013/10/22/ PY - 2013/07/02/received PY - 2013/09/26/revised PY - 2013/10/06/accepted PY - 2013/10/29/entrez PY - 2013/10/29/pubmed PY - 2014/8/19/medline KW - AAS KW - CPA KW - Cerebellar vermis KW - Chlorpheniramine KW - EPM KW - HA KW - Histamine KW - IUSDEC KW - Inhibitory avoidance KW - Memory consolidation KW - RA KW - Ranitidine KW - TMN KW - ascending arousal system KW - chlorpheniramine KW - elevated plus maze KW - histamine KW - i.c.v. KW - intracerebroventricular KW - inverted U-shaped dose effect curve KW - ranitidine KW - tuberomammillary nucleus SP - 159 EP - 64 JF - Neuroscience letters JO - Neurosci Lett VL - 557 Pt B N2 - Studies have demonstrated the relationship between the histaminergic system and the cerebellum, and we intend to investigate the role of the cerebellar histaminergic system on memory consolidation. This study investigated the effect of intra-cerebellar microinjection of histamine on memory retention of inhibitory avoidance in mice, and the role of H1 and H2 receptors in it. The cerebellar vermis of male mice were implanted with guide cannulae, and after three days of recovery, the inhibitory avoidance test was performed. Immediately after a training session, animals received a microinjection of histaminergic drugs: in the experiment 1, saline (SAL) or histamine (HA 0.54, 1.36, 2.72 or 4.07 nmol); experiment 2, SAL or 1.36 nmol HA 5 min after a pretreatment with 0.16 nmol chlorpheniramine (CPA) or SAL; and experiment 3, SAL or 1.36 nmol HA 5 min after a pretreatment with 2.85 nmol ranitidine (RA) or SAL. Twenty-four hours later, a retention test was performed. The data were analyzed using one-way analysis of variance (ANOVA) and Duncan's tests. In experiment 1, animals microinjected with 1.36 nmol HA showed a higher latency to cross to the dark compartment compared to controls and to 2.72 and 4.07 nmol HA groups. In experiment 2, the combined infusions revealed difference between control (SAL+SAL) and SAL+HA and CPA+HA; while in the experiment 3 the analysis indicated differences in retention latency between mice injected with SAL+SAL and SAL+HA. The groups that received the H2 antagonist RA did not show difference compared to control. These results indicate that 1.36 nmol HA enhances memory consolidation of inhibitory avoidance learning in mice and that the pretreatment with H2 antagonist RA was able to prevent this effect. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24161893/Intra_cerebellar_microinjection_of_histamine_enhances_memory_consolidation_of_inhibitory_avoidance_learning_in_mice_via_H2_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(13)00921-X DB - PRIME DP - Unbound Medicine ER -