Tags

Type your tag names separated by a space and hit enter

Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012.

Abstract

There is a lack of targeted studies to validate the effectiveness of influenza vaccination on the reduction in influenza-related hospitalizations among patients with co-morbidities. In this study, we estimate the effectiveness of influenza vaccination on preventing hospitalizations in persons with cardiopulmonary disease and establish an evidence base for recommendations on influenza vaccination in this population. During the influenza epidemic in 2011-2012, we performed a multicenter, retrospective case-control study. Cases were patients hospitalized due to acute exacerbation of asthma, COPD, ischemic heart disease (IHD), and congestive heart failure (CHF). Controls were selected from outpatients who visited study hospitals but who were not hospitalized. Cases and controls were matched 1:1 based on age, gender, and date of hospital visit. Conditional logistic regression analyses were used to determine the effectiveness of vaccination. Between 25 December 2011 and 5 May 2012, 828 of each hospitalized and control subjects were identified. The influenza vaccination rate of the hospitalized and non-hospitalized patients was 54.2% and 60.4%, respectively (P = 0.006). The overall vaccine effectiveness for preventing hospitalization was 33.7% (95% confidence interval [CI] 14.0-49.0%; P = 0.002). Conditional logistic regression analysis showed that influenza vaccination significantly reduced the risk of hospitalization, especially due to acute exacerbation of IHD and CHF, in patients aged 65 y and older. The estimated vaccine effectiveness in these patients was 56.0% (95% CI 32.1-71.4%, P = 0.002). Influenza vaccination was associated with a reduction in the risk of hospitalization due to acute exacerbation of cardiopulmonary disease. We recommend the vaccine be given primarily to patients with underlying cardiovascular disease, particularly those 65 y of age and older.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.

    ,

    Inha University College of Medicine; Incheon, South Korea.

    ,

    Hallym University College of Medicine; Chuncheon, South Korea.

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.

    ,

    Inha University College of Medicine; Incheon, South Korea.

    ,

    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.

    Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea; Transgovernmental Enterprise for Pandemic Influenza in Korea; Seoul, South Korea.

    Source

    MeSH

    Aged
    Aged, 80 and over
    Asthma
    Case-Control Studies
    Female
    Heart Failure
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Pulmonary Disease, Chronic Obstructive
    Republic of Korea
    Retrospective Studies
    Risk Assessment

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24161939

    Citation

    Seo, Yu Bin, et al. "Effectiveness of the Influenza Vaccine at Preventing Hospitalization Due to Acute Exacerbation of Cardiopulmonary Disease in Korea From 2011 to 2012." Human Vaccines & Immunotherapeutics, vol. 10, no. 2, 2014, pp. 423-7.
    Seo YB, Choi WS, Baek JH, et al. Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012. Hum Vaccin Immunother. 2014;10(2):423-7.
    Seo, Y. B., Choi, W. S., Baek, J. H., Lee, J., Song, J. Y., Lee, J. S., ... Kim, W. J. (2014). Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012. Human Vaccines & Immunotherapeutics, 10(2), pp. 423-7. doi:10.4161/hv.26858.
    Seo YB, et al. Effectiveness of the Influenza Vaccine at Preventing Hospitalization Due to Acute Exacerbation of Cardiopulmonary Disease in Korea From 2011 to 2012. Hum Vaccin Immunother. 2014;10(2):423-7. PubMed PMID: 24161939.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012. AU - Seo,Yu Bin, AU - Choi,Won Suk, AU - Baek,Ji Hyeon, AU - Lee,Jacob, AU - Song,Joon Young, AU - Lee,Jin Soo, AU - Cheong,Hee Jin, AU - Kim,Woo Joo, Y1 - 2013/10/25/ PY - 2013/10/29/entrez PY - 2013/10/29/pubmed PY - 2015/1/6/medline KW - cardiopulmonary disease KW - effectiveness KW - hospitalization KW - influenza vaccine SP - 423 EP - 7 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 10 IS - 2 N2 - There is a lack of targeted studies to validate the effectiveness of influenza vaccination on the reduction in influenza-related hospitalizations among patients with co-morbidities. In this study, we estimate the effectiveness of influenza vaccination on preventing hospitalizations in persons with cardiopulmonary disease and establish an evidence base for recommendations on influenza vaccination in this population. During the influenza epidemic in 2011-2012, we performed a multicenter, retrospective case-control study. Cases were patients hospitalized due to acute exacerbation of asthma, COPD, ischemic heart disease (IHD), and congestive heart failure (CHF). Controls were selected from outpatients who visited study hospitals but who were not hospitalized. Cases and controls were matched 1:1 based on age, gender, and date of hospital visit. Conditional logistic regression analyses were used to determine the effectiveness of vaccination. Between 25 December 2011 and 5 May 2012, 828 of each hospitalized and control subjects were identified. The influenza vaccination rate of the hospitalized and non-hospitalized patients was 54.2% and 60.4%, respectively (P = 0.006). The overall vaccine effectiveness for preventing hospitalization was 33.7% (95% confidence interval [CI] 14.0-49.0%; P = 0.002). Conditional logistic regression analysis showed that influenza vaccination significantly reduced the risk of hospitalization, especially due to acute exacerbation of IHD and CHF, in patients aged 65 y and older. The estimated vaccine effectiveness in these patients was 56.0% (95% CI 32.1-71.4%, P = 0.002). Influenza vaccination was associated with a reduction in the risk of hospitalization due to acute exacerbation of cardiopulmonary disease. We recommend the vaccine be given primarily to patients with underlying cardiovascular disease, particularly those 65 y of age and older. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/24161939/Effectiveness_of_the_influenza_vaccine_at_preventing_hospitalization_due_to_acute_exacerbation_of_cardiopulmonary_disease_in_Korea_from_2011_to_2012_ L2 - http://www.tandfonline.com/doi/full/10.4161/hv.26858 DB - PRIME DP - Unbound Medicine ER -