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Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012.
Hum Vaccin Immunother. 2014; 10(2):423-7.HV

Abstract

There is a lack of targeted studies to validate the effectiveness of influenza vaccination on the reduction in influenza-related hospitalizations among patients with co-morbidities. In this study, we estimate the effectiveness of influenza vaccination on preventing hospitalizations in persons with cardiopulmonary disease and establish an evidence base for recommendations on influenza vaccination in this population. During the influenza epidemic in 2011-2012, we performed a multicenter, retrospective case-control study. Cases were patients hospitalized due to acute exacerbation of asthma, COPD, ischemic heart disease (IHD), and congestive heart failure (CHF). Controls were selected from outpatients who visited study hospitals but who were not hospitalized. Cases and controls were matched 1:1 based on age, gender, and date of hospital visit. Conditional logistic regression analyses were used to determine the effectiveness of vaccination. Between 25 December 2011 and 5 May 2012, 828 of each hospitalized and control subjects were identified. The influenza vaccination rate of the hospitalized and non-hospitalized patients was 54.2% and 60.4%, respectively (P = 0.006). The overall vaccine effectiveness for preventing hospitalization was 33.7% (95% confidence interval [CI] 14.0-49.0%; P = 0.002). Conditional logistic regression analysis showed that influenza vaccination significantly reduced the risk of hospitalization, especially due to acute exacerbation of IHD and CHF, in patients aged 65 y and older. The estimated vaccine effectiveness in these patients was 56.0% (95% CI 32.1-71.4%, P = 0.002). Influenza vaccination was associated with a reduction in the risk of hospitalization due to acute exacerbation of cardiopulmonary disease. We recommend the vaccine be given primarily to patients with underlying cardiovascular disease, particularly those 65 y of age and older.

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Authors+Show Affiliations

Seo YB
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.
Choi WS
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.
Baek JH
Inha University College of Medicine; Incheon, South Korea.
Lee J
Hallym University College of Medicine; Chuncheon, South Korea.
Song JY
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.
Lee JS
Inha University College of Medicine; Incheon, South Korea.
Cheong HJ
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea.
Kim WJ
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine; Seoul, South Korea; Transgovernmental Enterprise for Pandemic Influenza in Korea; Seoul, South Korea.

MeSH

AgedAged, 80 and overAsthmaCase-Control StudiesFemaleHeart FailureHospitalizationHumansInfluenza VaccinesInfluenza, HumanMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRepublic of KoreaRetrospective StudiesRisk Assessment

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24161939

Citation

Seo, Yu Bin, et al. "Effectiveness of the Influenza Vaccine at Preventing Hospitalization Due to Acute Exacerbation of Cardiopulmonary Disease in Korea From 2011 to 2012." Human Vaccines & Immunotherapeutics, vol. 10, no. 2, 2014, pp. 423-7.
Seo YB, Choi WS, Baek JH, et al. Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012. Hum Vaccin Immunother. 2014;10(2):423-7.
Seo, Y. B., Choi, W. S., Baek, J. H., Lee, J., Song, J. Y., Lee, J. S., Cheong, H. J., & Kim, W. J. (2014). Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012. Human Vaccines & Immunotherapeutics, 10(2), 423-7. https://doi.org/10.4161/hv.26858
Seo YB, et al. Effectiveness of the Influenza Vaccine at Preventing Hospitalization Due to Acute Exacerbation of Cardiopulmonary Disease in Korea From 2011 to 2012. Hum Vaccin Immunother. 2014;10(2):423-7. PubMed PMID: 24161939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of the influenza vaccine at preventing hospitalization due to acute exacerbation of cardiopulmonary disease in Korea from 2011 to 2012. AU - Seo,Yu Bin, AU - Choi,Won Suk, AU - Baek,Ji Hyeon, AU - Lee,Jacob, AU - Song,Joon Young, AU - Lee,Jin Soo, AU - Cheong,Hee Jin, AU - Kim,Woo Joo, Y1 - 2013/10/25/ PY - 2013/10/29/entrez PY - 2013/10/29/pubmed PY - 2015/1/6/medline KW - cardiopulmonary disease KW - effectiveness KW - hospitalization KW - influenza vaccine SP - 423 EP - 7 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 10 IS - 2 N2 - There is a lack of targeted studies to validate the effectiveness of influenza vaccination on the reduction in influenza-related hospitalizations among patients with co-morbidities. In this study, we estimate the effectiveness of influenza vaccination on preventing hospitalizations in persons with cardiopulmonary disease and establish an evidence base for recommendations on influenza vaccination in this population. During the influenza epidemic in 2011-2012, we performed a multicenter, retrospective case-control study. Cases were patients hospitalized due to acute exacerbation of asthma, COPD, ischemic heart disease (IHD), and congestive heart failure (CHF). Controls were selected from outpatients who visited study hospitals but who were not hospitalized. Cases and controls were matched 1:1 based on age, gender, and date of hospital visit. Conditional logistic regression analyses were used to determine the effectiveness of vaccination. Between 25 December 2011 and 5 May 2012, 828 of each hospitalized and control subjects were identified. The influenza vaccination rate of the hospitalized and non-hospitalized patients was 54.2% and 60.4%, respectively (P = 0.006). The overall vaccine effectiveness for preventing hospitalization was 33.7% (95% confidence interval [CI] 14.0-49.0%; P = 0.002). Conditional logistic regression analysis showed that influenza vaccination significantly reduced the risk of hospitalization, especially due to acute exacerbation of IHD and CHF, in patients aged 65 y and older. The estimated vaccine effectiveness in these patients was 56.0% (95% CI 32.1-71.4%, P = 0.002). Influenza vaccination was associated with a reduction in the risk of hospitalization due to acute exacerbation of cardiopulmonary disease. We recommend the vaccine be given primarily to patients with underlying cardiovascular disease, particularly those 65 y of age and older. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/24161939/Effectiveness_of_the_influenza_vaccine_at_preventing_hospitalization_due_to_acute_exacerbation_of_cardiopulmonary_disease_in_Korea_from_2011_to_2012_ L2 - https://www.tandfonline.com/doi/full/10.4161/hv.26858 DB - PRIME DP - Unbound Medicine ER -