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Outcomes of a Postexposure Prophylaxis Program at the Korle-Bu Teaching Hospital in Ghana: A Retrospective Cohort Study.
J Int Assoc Provid AIDS Care. 2015 Nov-Dec; 14(6):544-52.JI

Abstract

The risk for occupational exposure to HIV is a serious public health problem that is well characterized in the developed world, but less so in the developing countries such as Ghana. This study was undertaken to examine the characteristics of occupational exposure to HIV and the utilization of a risk assessment system (RAS)-based postexposure prophylaxis (PEP) among health care workers (HCWs) and health care students (HCSs) in the Korle-Bu Teaching Hospital (KBTH). During the study period (January 2005-December 2010), a total of 260 and 35 exposures were reported by HCWs and HCSs, respectively. Ward attendants reported the highest incidence rate of 6.46 of 100 person-years (P-Y). The incidence of high-risk exposures was 0.33 of 100 P-Y (n = 65); 60.0% occurred during a procedure of disposing of a needle and 24.6% during a cannula insertion. A total of 289 of the 295 individuals were administered PEP, of which 181 (62.6%) completed the 6-month follow-up testing schedule and none sero-converted. This shows that with a good RAS in place, it is possible to deploy an effective PEP program in a typical African teaching hospital like the KBTH in Accra, Ghana.

Authors+Show Affiliations

Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands Pharmacy Department, Korle-Bu Teaching Hospital, Korle-Bu, Accra, Ghana r_niiatetteh@yahoo.com.Centre for Tropical Clinical Pharmacology & Therapeutics, University of Ghana Medical School, Accra, Ghana.Department of Medicine, University of Ghana Medical School, Accra, Ghana.Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands Medicines Evaluation Board, Utrecht, the Netherlands.Department of Epidemiology and Disease Control, School of Public Health, University of Ghana, Legon, Accra, Ghana.Centre for Tropical Clinical Pharmacology & Therapeutics, University of Ghana Medical School, Accra, Ghana.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24162616

Citation

Tetteh, Raymond A., et al. "Outcomes of a Postexposure Prophylaxis Program at the Korle-Bu Teaching Hospital in Ghana: a Retrospective Cohort Study." Journal of the International Association of Providers of AIDS Care, vol. 14, no. 6, 2015, pp. 544-52.
Tetteh RA, Nartey ET, Lartey M, et al. Outcomes of a Postexposure Prophylaxis Program at the Korle-Bu Teaching Hospital in Ghana: A Retrospective Cohort Study. J Int Assoc Provid AIDS Care. 2015;14(6):544-52.
Tetteh, R. A., Nartey, E. T., Lartey, M., Mantel-Teeuwisse, A. K., Leufkens, H. G., Nortey, P. A., & Dodoo, A. N. (2015). Outcomes of a Postexposure Prophylaxis Program at the Korle-Bu Teaching Hospital in Ghana: A Retrospective Cohort Study. Journal of the International Association of Providers of AIDS Care, 14(6), 544-52. https://doi.org/10.1177/2325957413508321
Tetteh RA, et al. Outcomes of a Postexposure Prophylaxis Program at the Korle-Bu Teaching Hospital in Ghana: a Retrospective Cohort Study. J Int Assoc Provid AIDS Care. 2015 Nov-Dec;14(6):544-52. PubMed PMID: 24162616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes of a Postexposure Prophylaxis Program at the Korle-Bu Teaching Hospital in Ghana: A Retrospective Cohort Study. AU - Tetteh,Raymond A, AU - Nartey,Edmund T, AU - Lartey,Margaret, AU - Mantel-Teeuwisse,Aukje K, AU - Leufkens,Hubert G M, AU - Nortey,Priscilla A, AU - Dodoo,Alexander N O, Y1 - 2013/10/25/ PY - 2013/10/29/entrez PY - 2013/10/29/pubmed PY - 2016/3/11/medline KW - HIV risk exposures KW - health care workers KW - postexposure prophylaxis KW - risk assessment system SP - 544 EP - 52 JF - Journal of the International Association of Providers of AIDS Care JO - J Int Assoc Provid AIDS Care VL - 14 IS - 6 N2 - The risk for occupational exposure to HIV is a serious public health problem that is well characterized in the developed world, but less so in the developing countries such as Ghana. This study was undertaken to examine the characteristics of occupational exposure to HIV and the utilization of a risk assessment system (RAS)-based postexposure prophylaxis (PEP) among health care workers (HCWs) and health care students (HCSs) in the Korle-Bu Teaching Hospital (KBTH). During the study period (January 2005-December 2010), a total of 260 and 35 exposures were reported by HCWs and HCSs, respectively. Ward attendants reported the highest incidence rate of 6.46 of 100 person-years (P-Y). The incidence of high-risk exposures was 0.33 of 100 P-Y (n = 65); 60.0% occurred during a procedure of disposing of a needle and 24.6% during a cannula insertion. A total of 289 of the 295 individuals were administered PEP, of which 181 (62.6%) completed the 6-month follow-up testing schedule and none sero-converted. This shows that with a good RAS in place, it is possible to deploy an effective PEP program in a typical African teaching hospital like the KBTH in Accra, Ghana. SN - 2325-9574 UR - https://www.unboundmedicine.com/medline/citation/24162616/Outcomes_of_a_Postexposure_Prophylaxis_Program_at_the_Korle_Bu_Teaching_Hospital_in_Ghana:_A_Retrospective_Cohort_Study_ L2 - https://journals.sagepub.com/doi/10.1177/2325957413508321?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -