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Diplopia and variable ptosis as the sole initial findings in a case of orbital plasmacytoma and multiple myeloma.
Semin Ophthalmol. 2015 May; 30(3):235-7.SO

Abstract

Plasmacytomas are monoclonal plasma cell tumors. They represent 3% of all orbital tumors. We present an unusual case of orbital plasmacytoma and advanced multiple myeloma where the sole presenting symptoms were those of diplopia and ptosis. Clinical examination revealed right hypertropia and variable left upper lid ptosis but no proptosis. The visual acuity and the rest of the ocular examination were normal in both eyes. An MRI scan of the brain and orbits revealed a frontal bone lesion consistent with a plasmacytoma. A bone marrow biopsy showed a light chain multiple myeloma with free lambda light chains. Although the literature reports diplopia and ptosis as being clinical features of orbital plasmacytomas, to our knowledge this is the first reported case where these symptoms were the only presenting features, despite widespread disease.

Authors+Show Affiliations

Department of Ophthalmology, Tennent Institute of Ophthalmology, Gartnavel General Hospital , Glasgow , UK and.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24164055

Citation

Galea, Martin, et al. "Diplopia and Variable Ptosis as the Sole Initial Findings in a Case of Orbital Plasmacytoma and Multiple Myeloma." Seminars in Ophthalmology, vol. 30, no. 3, 2015, pp. 235-7.
Galea M, McMillan N, Weir C. Diplopia and variable ptosis as the sole initial findings in a case of orbital plasmacytoma and multiple myeloma. Semin Ophthalmol. 2015;30(3):235-7.
Galea, M., McMillan, N., & Weir, C. (2015). Diplopia and variable ptosis as the sole initial findings in a case of orbital plasmacytoma and multiple myeloma. Seminars in Ophthalmology, 30(3), 235-7. https://doi.org/10.3109/13506129.2013.839807
Galea M, McMillan N, Weir C. Diplopia and Variable Ptosis as the Sole Initial Findings in a Case of Orbital Plasmacytoma and Multiple Myeloma. Semin Ophthalmol. 2015;30(3):235-7. PubMed PMID: 24164055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diplopia and variable ptosis as the sole initial findings in a case of orbital plasmacytoma and multiple myeloma. AU - Galea,Martin, AU - McMillan,Nigel, AU - Weir,Clifford, Y1 - 2013/10/28/ PY - 2013/10/30/entrez PY - 2013/10/30/pubmed PY - 2015/10/16/medline KW - Diplopia KW - multiple myeloma KW - orbit KW - plasmacytoma KW - ptosis SP - 235 EP - 7 JF - Seminars in ophthalmology JO - Semin Ophthalmol VL - 30 IS - 3 N2 - Plasmacytomas are monoclonal plasma cell tumors. They represent 3% of all orbital tumors. We present an unusual case of orbital plasmacytoma and advanced multiple myeloma where the sole presenting symptoms were those of diplopia and ptosis. Clinical examination revealed right hypertropia and variable left upper lid ptosis but no proptosis. The visual acuity and the rest of the ocular examination were normal in both eyes. An MRI scan of the brain and orbits revealed a frontal bone lesion consistent with a plasmacytoma. A bone marrow biopsy showed a light chain multiple myeloma with free lambda light chains. Although the literature reports diplopia and ptosis as being clinical features of orbital plasmacytomas, to our knowledge this is the first reported case where these symptoms were the only presenting features, despite widespread disease. SN - 1744-5205 UR - https://www.unboundmedicine.com/medline/citation/24164055/Diplopia_and_variable_ptosis_as_the_sole_initial_findings_in_a_case_of_orbital_plasmacytoma_and_multiple_myeloma_ L2 - http://www.tandfonline.com/doi/full/10.3109/13506129.2013.839807 DB - PRIME DP - Unbound Medicine ER -