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Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study.
J Oral Pathol Med. 2014 Jul; 43(6):405-9.JO

Abstract

OBJECTIVE

To evaluate the clinical efficacy, and safety of newly customized natural oral mucoadhesive gels, containing either aloe vera or myrrh as active ingredients, in the management of minor recurrent aphthous stomatitis (MiRAS).

SUBJECTS AND METHODS

Ninety subjects with MiRAS were recruited from Oral Medicine Clinic, at Faculty of Dentistry, King Abdulaziz University, Saudi Arabia, for this randomized, double-blind, placebo-controlled study. Two new natural gels, containing aloe vera and myrrh, were prepared in a concentration of (0.5% w/w), in addition to a plain mucoadhesive gel used as a placebo. Patients with fresh ulcers (<48-h duration) were instructed to apply either one of the three gels four times a day for a period of 5 days. Clinical efficacy was investigated in the form of changes in ulcer size, pain intensity, erythema, and exudation at days 4 and 6 of study entry. Participants were interviewed for the emergence of any side effects.

RESULTS

76.6% of patients using aloe gel showed complete ulcer healing, 86.7%, and 80% of them revealed subsidence of erythema and exudation, respectively, especially at day 6 visit, whereas 76.7% of myrrh-treated patients revealed almost absence of pain at day 6. No side effects were encountered with the use of any of the three gels.

CONCLUSION

The new formulated aloe- and myrrh-based gels proved to be effective in topical management of MiRAS. Aloe was superior in decreasing ulcer size, erythema, and exudation; whereas myrrh resulted in more pain reduction.

Authors+Show Affiliations

Department of Oral Basic and Clinical Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24164309

Citation

Mansour, Ghada, et al. "Clinical Efficacy of New Aloe Vera- and Myrrh-based Oral Mucoadhesive Gels in the Management of Minor Recurrent Aphthous Stomatitis: a Randomized, Double-blind, Vehicle-controlled Study." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 43, no. 6, 2014, pp. 405-9.
Mansour G, Ouda S, Shaker A, et al. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. J Oral Pathol Med. 2014;43(6):405-9.
Mansour, G., Ouda, S., Shaker, A., & Abdallah, H. M. (2014). Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(6), 405-9. https://doi.org/10.1111/jop.12130
Mansour G, et al. Clinical Efficacy of New Aloe Vera- and Myrrh-based Oral Mucoadhesive Gels in the Management of Minor Recurrent Aphthous Stomatitis: a Randomized, Double-blind, Vehicle-controlled Study. J Oral Pathol Med. 2014;43(6):405-9. PubMed PMID: 24164309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. AU - Mansour,Ghada, AU - Ouda,Soliman, AU - Shaker,Ahmed, AU - Abdallah,Hossam M, Y1 - 2013/10/25/ PY - 2013/09/26/accepted PY - 2013/10/30/entrez PY - 2013/10/30/pubmed PY - 2015/5/13/medline KW - aloe KW - aphthous ulceration KW - myrrh KW - oral mucosa SP - 405 EP - 9 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 43 IS - 6 N2 - OBJECTIVE: To evaluate the clinical efficacy, and safety of newly customized natural oral mucoadhesive gels, containing either aloe vera or myrrh as active ingredients, in the management of minor recurrent aphthous stomatitis (MiRAS). SUBJECTS AND METHODS: Ninety subjects with MiRAS were recruited from Oral Medicine Clinic, at Faculty of Dentistry, King Abdulaziz University, Saudi Arabia, for this randomized, double-blind, placebo-controlled study. Two new natural gels, containing aloe vera and myrrh, were prepared in a concentration of (0.5% w/w), in addition to a plain mucoadhesive gel used as a placebo. Patients with fresh ulcers (<48-h duration) were instructed to apply either one of the three gels four times a day for a period of 5 days. Clinical efficacy was investigated in the form of changes in ulcer size, pain intensity, erythema, and exudation at days 4 and 6 of study entry. Participants were interviewed for the emergence of any side effects. RESULTS: 76.6% of patients using aloe gel showed complete ulcer healing, 86.7%, and 80% of them revealed subsidence of erythema and exudation, respectively, especially at day 6 visit, whereas 76.7% of myrrh-treated patients revealed almost absence of pain at day 6. No side effects were encountered with the use of any of the three gels. CONCLUSION: The new formulated aloe- and myrrh-based gels proved to be effective in topical management of MiRAS. Aloe was superior in decreasing ulcer size, erythema, and exudation; whereas myrrh resulted in more pain reduction. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/24164309/Clinical_efficacy_of_new_aloe_vera__and_myrrh_based_oral_mucoadhesive_gels_in_the_management_of_minor_recurrent_aphthous_stomatitis:_a_randomized_double_blind_vehicle_controlled_study_ L2 - https://doi.org/10.1111/jop.12130 DB - PRIME DP - Unbound Medicine ER -