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Effects of red wine on established markers of arterial structure and function in human studies: current knowledge and future research directions.
Expert Rev Clin Pharmacol 2013; 6(6):613-25ER

Abstract

Evidence from observational studies suggests that mild-to-moderate consumption of red wine is associated with reduced cardiovascular morbidity and mortality. Various individual chemical components of red wine also show salutary effects on vascular homeostasis, that is, enhanced endothelial function and arterial distensibility, both in vitro and in animal studies. However, testing the beneficial potential of red wine in primary and secondary cardiovascular prevention on established surrogate cardiovascular markers requires further study with longer term intervention trials. This report reviews and critically appraises the published evidence for the effects of red wine on endothelium-dependent vasodilation, arterial stiffness and arterial wave reflections in healthy subjects and in patients with cardiovascular disease. Suggestions for future research directions are also provided.

Authors+Show Affiliations

Discipline of Clinical Pharmacology, School of Medicine, Flinders University and Flinders Medical Centre, Flinders Drive, Bedford Park, SA 5042, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24164610

Citation

Mangoni, Arduino A., et al. "Effects of Red Wine On Established Markers of Arterial Structure and Function in Human Studies: Current Knowledge and Future Research Directions." Expert Review of Clinical Pharmacology, vol. 6, no. 6, 2013, pp. 613-25.
Mangoni AA, Stockley CS, Woodman RJ. Effects of red wine on established markers of arterial structure and function in human studies: current knowledge and future research directions. Expert Rev Clin Pharmacol. 2013;6(6):613-25.
Mangoni, A. A., Stockley, C. S., & Woodman, R. J. (2013). Effects of red wine on established markers of arterial structure and function in human studies: current knowledge and future research directions. Expert Review of Clinical Pharmacology, 6(6), pp. 613-25. doi:10.1586/17512433.2013.841077.
Mangoni AA, Stockley CS, Woodman RJ. Effects of Red Wine On Established Markers of Arterial Structure and Function in Human Studies: Current Knowledge and Future Research Directions. Expert Rev Clin Pharmacol. 2013;6(6):613-25. PubMed PMID: 24164610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of red wine on established markers of arterial structure and function in human studies: current knowledge and future research directions. AU - Mangoni,Arduino A, AU - Stockley,Creina S, AU - Woodman,Richard J, PY - 2013/10/30/entrez PY - 2013/10/30/pubmed PY - 2014/6/3/medline SP - 613 EP - 25 JF - Expert review of clinical pharmacology JO - Expert Rev Clin Pharmacol VL - 6 IS - 6 N2 - Evidence from observational studies suggests that mild-to-moderate consumption of red wine is associated with reduced cardiovascular morbidity and mortality. Various individual chemical components of red wine also show salutary effects on vascular homeostasis, that is, enhanced endothelial function and arterial distensibility, both in vitro and in animal studies. However, testing the beneficial potential of red wine in primary and secondary cardiovascular prevention on established surrogate cardiovascular markers requires further study with longer term intervention trials. This report reviews and critically appraises the published evidence for the effects of red wine on endothelium-dependent vasodilation, arterial stiffness and arterial wave reflections in healthy subjects and in patients with cardiovascular disease. Suggestions for future research directions are also provided. SN - 1751-2441 UR - https://www.unboundmedicine.com/medline/citation/24164610/Effects_of_red_wine_on_established_markers_of_arterial_structure_and_function_in_human_studies:_current_knowledge_and_future_research_directions L2 - http://www.tandfonline.com/doi/full/10.1586/17512433.2013.841077 DB - PRIME DP - Unbound Medicine ER -