Tags

Type your tag names separated by a space and hit enter

Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study.
Clin Infect Dis. 2014 Jan; 58(2):197-203.CI

Abstract

BACKGROUND

An association between use of oral fluoroquinolones (FQs) and retinal detachment remains controversial. This study was to determine the association of recent use of oral FQs and rhegmatogenous retinal detachment (RRD) after adjustment for confounding factors known to be associated with RRD.

METHODS

This retrospective population-based cohort study with parallel groups included adults treated with an oral FQ (FQ cohort = 178 179 prescriptions) and propensity score-matched adults treated with oral amoxicillin (amoxicillin cohort = 178 179 prescriptions). The data were extracted from the Taiwan National Health Insurance Research Database from 1998 to 2010. Interaction terms were used to identify populations at risk. RRD was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification.

RESULTS

During the 90-day follow-up period, 96 patients (0.054%) in the FQ cohort developed RRD compared to 46 (0.026%) among the matched amoxicillin cohort. The overall adjusted hazard ratio (HR) for FQ use and RRD was 2.07 (95% confidence interval [CI], 1.45-2.96). The interval between use of oral FQs and onset of RRD was 35.5 days (interquartile range, 14-57 days). Interaction terms were not significant for age, sex, diabetes, indications for antimicrobials, or underlying ophthalmic conditions. The adjusted HRs differed for specific FQs. These were 10.68 (95% CI, 3.28-34.82) for ciprofloxacin, 2.41 (95% CI, .76-7.68) for levofloxacin, 2.00 (95% CI, 1.06-3.79) for norfloxacin, and 1.17 (95% CI, .59-2.31) for ofloxacin.

CONCLUSIONS

The use of oral FQs was associated with the subsequent occurrence of RRD. The FQ risk was independent of age, sex, diabetes, indications for antimicrobials, and underlying ophthalmic conditions. Certain FQs carried higher risk of RRD.

Authors+Show Affiliations

Institute of Clinical Medicine, School of Medicine, National Yang-Ming University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24170197

Citation

Kuo, Shu-Chen, et al. "Association Between Recent Use of Fluoroquinolones and Rhegmatogenous Retinal Detachment: a Population-based Cohort Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 58, no. 2, 2014, pp. 197-203.
Kuo SC, Chen YT, Lee YT, et al. Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study. Clin Infect Dis. 2014;58(2):197-203.
Kuo, S. C., Chen, Y. T., Lee, Y. T., Fan, N. W., Chen, S. J., Li, S. Y., Liu, C. J., Chen, T. L., Chen, T. J., & Fung, C. P. (2014). Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 58(2), 197-203. https://doi.org/10.1093/cid/cit708
Kuo SC, et al. Association Between Recent Use of Fluoroquinolones and Rhegmatogenous Retinal Detachment: a Population-based Cohort Study. Clin Infect Dis. 2014;58(2):197-203. PubMed PMID: 24170197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between recent use of fluoroquinolones and rhegmatogenous retinal detachment: a population-based cohort study. AU - Kuo,Shu-Chen, AU - Chen,Yung-Tai, AU - Lee,Yi-Tzu, AU - Fan,Nai-Wen, AU - Chen,Shih-Jen, AU - Li,Szu-Yuan, AU - Liu,Chia-Jen, AU - Chen,Te-Li, AU - Chen,Tzeng-Ji, AU - Fung,Chang-Phone, Y1 - 2013/10/28/ PY - 2013/10/31/entrez PY - 2013/10/31/pubmed PY - 2014/8/21/medline KW - fluoroquinolones KW - rhegmatogenous retinal detachment KW - risks SP - 197 EP - 203 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 58 IS - 2 N2 - BACKGROUND: An association between use of oral fluoroquinolones (FQs) and retinal detachment remains controversial. This study was to determine the association of recent use of oral FQs and rhegmatogenous retinal detachment (RRD) after adjustment for confounding factors known to be associated with RRD. METHODS: This retrospective population-based cohort study with parallel groups included adults treated with an oral FQ (FQ cohort = 178 179 prescriptions) and propensity score-matched adults treated with oral amoxicillin (amoxicillin cohort = 178 179 prescriptions). The data were extracted from the Taiwan National Health Insurance Research Database from 1998 to 2010. Interaction terms were used to identify populations at risk. RRD was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification. RESULTS: During the 90-day follow-up period, 96 patients (0.054%) in the FQ cohort developed RRD compared to 46 (0.026%) among the matched amoxicillin cohort. The overall adjusted hazard ratio (HR) for FQ use and RRD was 2.07 (95% confidence interval [CI], 1.45-2.96). The interval between use of oral FQs and onset of RRD was 35.5 days (interquartile range, 14-57 days). Interaction terms were not significant for age, sex, diabetes, indications for antimicrobials, or underlying ophthalmic conditions. The adjusted HRs differed for specific FQs. These were 10.68 (95% CI, 3.28-34.82) for ciprofloxacin, 2.41 (95% CI, .76-7.68) for levofloxacin, 2.00 (95% CI, 1.06-3.79) for norfloxacin, and 1.17 (95% CI, .59-2.31) for ofloxacin. CONCLUSIONS: The use of oral FQs was associated with the subsequent occurrence of RRD. The FQ risk was independent of age, sex, diabetes, indications for antimicrobials, and underlying ophthalmic conditions. Certain FQs carried higher risk of RRD. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/24170197/Association_between_recent_use_of_fluoroquinolones_and_rhegmatogenous_retinal_detachment:_a_population-based_cohort_study L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cit708 DB - PRIME DP - Unbound Medicine ER -