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Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation.
J Am Assoc Nurse Pract. 2014 Feb; 26(2):85-90.JA

Abstract

PURPOSE

Heart disease is the leading cause of death in the United States. HMG-CoA reductase inhibitors, or statins, are medications at the forefront of the battle against cardiovascular disease. Despite their effectiveness, patient compliance with statins has lagged because of medication cost and adverse effects, namely myopathy. Myopathy is the most common side effect of statin use. The purpose of this review is to report plasma levels of CoQ10 in patients taking statins and then to determine the benefit of Coenzyme Q10 (CoQ10) supplementation on statin-related myopathy as evidenced by symptomatic improvement and increase in serum levels of CoQ10.

DATA SOURCES

CINAHL, Medline, Health Source: Nursing/Academic Edition, and Cochrane Library.

CONCLUSIONS

Evidence from this review suggests that studies showed a significant relationship between statin intake and decreased serum levels of CoQ10. A few studies showed a benefit in symptoms of myalgia or improvement of serum levels of CoQ10 with supplementation. One study showed no benefit of CoQ10 supplementation when taken with statins. There were no risks of supplementation reported in any of the studies.

IMPLICATIONS FOR PRACTICE

CoQ10 supplementation might benefit those patients suffering from statin-induced myopathy as evidenced by the results of these studies. Supplementation of CoQ10 at a dose of between 30 and 200 mg daily has shown to have beneficial effects on statin myopathy with no noted side effects. Further research is necessary.

Authors+Show Affiliations

The Orthopedic Specialty Group, LDS Hospital Orthopedics, Salt Lake City, Utah.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24170646

Citation

Littlefield, Nate, et al. "Statins' Effect On Plasma Levels of Coenzyme Q10 and Improvement in Myopathy With Supplementation." Journal of the American Association of Nurse Practitioners, vol. 26, no. 2, 2014, pp. 85-90.
Littlefield N, Beckstrand RL, Luthy KE. Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation. J Am Assoc Nurse Pract. 2014;26(2):85-90.
Littlefield, N., Beckstrand, R. L., & Luthy, K. E. (2014). Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation. Journal of the American Association of Nurse Practitioners, 26(2), 85-90. https://doi.org/10.1002/2327-6924.12046
Littlefield N, Beckstrand RL, Luthy KE. Statins' Effect On Plasma Levels of Coenzyme Q10 and Improvement in Myopathy With Supplementation. J Am Assoc Nurse Pract. 2014;26(2):85-90. PubMed PMID: 24170646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation. AU - Littlefield,Nate, AU - Beckstrand,Renea L, AU - Luthy,Karlen E, Y1 - 2013/07/12/ PY - 2011/07/29/received PY - 2012/06/14/accepted PY - 2013/10/31/entrez PY - 2013/10/31/pubmed PY - 2015/4/12/medline KW - CoQ10 KW - Statin KW - myalgia KW - myopathy KW - supplementation SP - 85 EP - 90 JF - Journal of the American Association of Nurse Practitioners JO - J Am Assoc Nurse Pract VL - 26 IS - 2 N2 - PURPOSE: Heart disease is the leading cause of death in the United States. HMG-CoA reductase inhibitors, or statins, are medications at the forefront of the battle against cardiovascular disease. Despite their effectiveness, patient compliance with statins has lagged because of medication cost and adverse effects, namely myopathy. Myopathy is the most common side effect of statin use. The purpose of this review is to report plasma levels of CoQ10 in patients taking statins and then to determine the benefit of Coenzyme Q10 (CoQ10) supplementation on statin-related myopathy as evidenced by symptomatic improvement and increase in serum levels of CoQ10. DATA SOURCES: CINAHL, Medline, Health Source: Nursing/Academic Edition, and Cochrane Library. CONCLUSIONS: Evidence from this review suggests that studies showed a significant relationship between statin intake and decreased serum levels of CoQ10. A few studies showed a benefit in symptoms of myalgia or improvement of serum levels of CoQ10 with supplementation. One study showed no benefit of CoQ10 supplementation when taken with statins. There were no risks of supplementation reported in any of the studies. IMPLICATIONS FOR PRACTICE: CoQ10 supplementation might benefit those patients suffering from statin-induced myopathy as evidenced by the results of these studies. Supplementation of CoQ10 at a dose of between 30 and 200 mg daily has shown to have beneficial effects on statin myopathy with no noted side effects. Further research is necessary. SN - 2327-6924 UR - https://www.unboundmedicine.com/medline/citation/24170646/Statins'_effect_on_plasma_levels_of_Coenzyme_Q10_and_improvement_in_myopathy_with_supplementation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=2327-6886&date=2014&volume=26&issue=2&spage=85 DB - PRIME DP - Unbound Medicine ER -