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The chemokine receptor 5 delta32 polymorphism and type 1 diabetes, Behcet's disease, and asthma: a meta-analysis.
Immunol Invest 2014; 43(2):123-36II

Abstract

OBJECTIVE

The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to type 1 diabetes (T1D), Behcet's disease (BD), and asthma.

RESULTS

Fourteen studies encompassing 9,656 cases and 12,431 controls, including 6 on T1D, 5 on BD, and 3 on asthma, were available for meta-analysis. The meta-analysis showed a significant negative association between T1D and the CCR5-Δ32 allele (odds ratio [OR] = 0.854, 95% confidence interval [CI] = 0.800-0.912, p = 2.2 × 10⁻⁷). Stratification by ethnicity and analysis of the Δ32Δ32 + Δ32W genotype indicated a significant negative association between the CCR5-Δ32 allele and T1D in Europeans (OR = 0.857, 95% CI = 0.802-0.915, p = 3.5 × 10⁻⁸; OR = 0.896, 95% CI = 0.808-0.932, p = 9.3 × 10⁻⁶, respectively). The meta-analysis showed a positive association between BD and the Δ32Δ32 + Δ32W genotype (OR = 1.403, 95% CI = 1.008-1.954, p = 0.045). Stratification by HLA-B51 status indicated an association between the CCR5-Δ32 allele and HLA-B51-positive BD, but not HLA-B51-negative BD (OR = 1.619, 95% CI = 1.070-2.451, p = 0.023; OR = 1.036, 95% CI = 0.674-1.593, p = 0.872, respectively). No association was found between the CCR5-Δ32 polymorphism and asthma.

CONCLUSIONS

This meta-analysis demonstrates that the CCR5-Δ32 polymorphism acts as a protective factor in T1D development in Europeans, and a risk factor for BD among HLA-B51 carriers. However, no association was found between the CCR5-Δ32 polymorphism and asthma.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24171669

Citation

Song, Gwan Gyu, et al. "The Chemokine Receptor 5 Delta32 Polymorphism and Type 1 Diabetes, Behcet's Disease, and Asthma: a Meta-analysis." Immunological Investigations, vol. 43, no. 2, 2014, pp. 123-36.
Song GG, Kim JH, Lee YH. The chemokine receptor 5 delta32 polymorphism and type 1 diabetes, Behcet's disease, and asthma: a meta-analysis. Immunol Invest. 2014;43(2):123-36.
Song, G. G., Kim, J. H., & Lee, Y. H. (2014). The chemokine receptor 5 delta32 polymorphism and type 1 diabetes, Behcet's disease, and asthma: a meta-analysis. Immunological Investigations, 43(2), pp. 123-36. doi:10.3109/08820139.2013.847457.
Song GG, Kim JH, Lee YH. The Chemokine Receptor 5 Delta32 Polymorphism and Type 1 Diabetes, Behcet's Disease, and Asthma: a Meta-analysis. Immunol Invest. 2014;43(2):123-36. PubMed PMID: 24171669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chemokine receptor 5 delta32 polymorphism and type 1 diabetes, Behcet's disease, and asthma: a meta-analysis. AU - Song,Gwan Gyu, AU - Kim,Jae-Hoon, AU - Lee,Young Ho, Y1 - 2013/10/30/ PY - 2013/11/1/entrez PY - 2013/11/1/pubmed PY - 2014/10/4/medline SP - 123 EP - 36 JF - Immunological investigations JO - Immunol. Invest. VL - 43 IS - 2 N2 - OBJECTIVE: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to type 1 diabetes (T1D), Behcet's disease (BD), and asthma. RESULTS: Fourteen studies encompassing 9,656 cases and 12,431 controls, including 6 on T1D, 5 on BD, and 3 on asthma, were available for meta-analysis. The meta-analysis showed a significant negative association between T1D and the CCR5-Δ32 allele (odds ratio [OR] = 0.854, 95% confidence interval [CI] = 0.800-0.912, p = 2.2 × 10⁻⁷). Stratification by ethnicity and analysis of the Δ32Δ32 + Δ32W genotype indicated a significant negative association between the CCR5-Δ32 allele and T1D in Europeans (OR = 0.857, 95% CI = 0.802-0.915, p = 3.5 × 10⁻⁸; OR = 0.896, 95% CI = 0.808-0.932, p = 9.3 × 10⁻⁶, respectively). The meta-analysis showed a positive association between BD and the Δ32Δ32 + Δ32W genotype (OR = 1.403, 95% CI = 1.008-1.954, p = 0.045). Stratification by HLA-B51 status indicated an association between the CCR5-Δ32 allele and HLA-B51-positive BD, but not HLA-B51-negative BD (OR = 1.619, 95% CI = 1.070-2.451, p = 0.023; OR = 1.036, 95% CI = 0.674-1.593, p = 0.872, respectively). No association was found between the CCR5-Δ32 polymorphism and asthma. CONCLUSIONS: This meta-analysis demonstrates that the CCR5-Δ32 polymorphism acts as a protective factor in T1D development in Europeans, and a risk factor for BD among HLA-B51 carriers. However, no association was found between the CCR5-Δ32 polymorphism and asthma. SN - 1532-4311 UR - https://www.unboundmedicine.com/medline/citation/24171669/The_chemokine_receptor_5_delta32_polymorphism_and_type_1_diabetes_Behcet's_disease_and_asthma:_a_meta_analysis_ L2 - http://www.tandfonline.com/doi/full/10.3109/08820139.2013.847457 DB - PRIME DP - Unbound Medicine ER -